ID   URB2_SCHPO              Reviewed;        1318 AA.
AC   Q09804;
DT   01-NOV-1995, integrated into UniProtKB/Swiss-Prot.
DT   30-MAY-2000, sequence version 2.
DT   25-MAY-2022, entry version 95.
DE   RecName: Full=Probable nucleolar pre-ribosomal-associated protein 2;
DE   AltName: Full=Ribosome biogenesis protein urb2;
GN   Name=urb2; ORFNames=SPAC2G11.02;
OS   Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina;
OC   Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae;
OC   Schizosaccharomyces.
OX   NCBI_TaxID=284812;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=972 / ATCC 24843;
RX   PubMed=11859360; DOI=10.1038/nature724;
RA   Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A.,
RA   Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S.,
RA   Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.,
RA   Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S.,
RA   Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S.,
RA   Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D.,
RA   Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P.,
RA   Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K.,
RA   O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M.,
RA   Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N.,
RA   Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A.,
RA   Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R.,
RA   Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M.,
RA   Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A.,
RA   Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A.,
RA   Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H.,
RA   Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S.,
RA   Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C.,
RA   Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A.,
RA   Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M.,
RA   del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S.,
RA   Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R.,
RA   Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G.,
RA   Nurse P.;
RT   "The genome sequence of Schizosaccharomyces pombe.";
RL   Nature 415:871-880(2002).
RN   [2]
RP   SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
RX   PubMed=16823372; DOI=10.1038/nbt1222;
RA   Matsuyama A., Arai R., Yashiroda Y., Shirai A., Kamata A., Sekido S.,
RA   Kobayashi Y., Hashimoto A., Hamamoto M., Hiraoka Y., Horinouchi S.,
RA   Yoshida M.;
RT   "ORFeome cloning and global analysis of protein localization in the fission
RT   yeast Schizosaccharomyces pombe.";
RL   Nat. Biotechnol. 24:841-847(2006).
CC   -!- FUNCTION: Required for 27S pre-rRNA processing. Has an early role
CC       during 60S ribosomal subunit assembly (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm, cytosol {ECO:0000269|PubMed:16823372}.
CC       Nucleus, nucleolus {ECO:0000250}.
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DR   EMBL; CU329670; CAA91167.1; -; Genomic_DNA.
DR   PIR; S62457; S62457.
DR   PIR; T38568; T38568.
DR   RefSeq; NP_593082.1; NM_001018480.2.
DR   AlphaFoldDB; Q09804; -.
DR   BioGRID; 278017; 1.
DR   STRING; 4896.SPAC2G11.02.1; -.
DR   MaxQB; Q09804; -.
DR   PaxDb; Q09804; -.
DR   PRIDE; Q09804; -.
DR   EnsemblFungi; SPAC2G11.02.1; SPAC2G11.02.1:pep; SPAC2G11.02.
DR   GeneID; 2541516; -.
DR   KEGG; spo:SPAC2G11.02; -.
DR   PomBase; SPAC2G11.02; urb2.
DR   VEuPathDB; FungiDB:SPAC2G11.02; -.
DR   eggNOG; ENOG502QTEB; Eukaryota.
DR   HOGENOM; CLU_260347_0_0_1; -.
DR   InParanoid; Q09804; -.
DR   OMA; NPNLMHD; -.
DR   PRO; PR:Q09804; -.
DR   Proteomes; UP000002485; Chromosome I.
DR   GO; GO:0005829; C:cytosol; HDA:PomBase.
DR   GO; GO:0005730; C:nucleolus; ISS:PomBase.
DR   GO; GO:0042254; P:ribosome biogenesis; ISS:PomBase.
DR   GO; GO:0006364; P:rRNA processing; IEA:UniProtKB-KW.
DR   InterPro; IPR018849; Urb2/Npa2_C.
DR   Pfam; PF10441; Urb2; 1.
PE   3: Inferred from homology;
KW   Cytoplasm; Nucleus; Reference proteome; Ribosome biogenesis;
KW   rRNA processing.
FT   CHAIN           1..1318
FT                   /note="Probable nucleolar pre-ribosomal-associated protein
FT                   2"
FT                   /id="PRO_0000116409"
SQ   SEQUENCE   1318 AA;  151570 MW;  4735560E45B2E03A CRC64;
     MSLQTLTKRI RDKNGSREDQ IDLANKLFRG EVDVYFPNKE EFIINFLLDR LKENSNLTCV
     NIGYWQLFLN IWKSDKLSGS FRVSAIRRQS LYPIILNAFE YLIKEFKKDV FLKISDVFVC
     VYSNLNILYI SRSFPDQISL LFSRYCYLIA SKIDDLLDSH PNEVFKETLI CVIQSAVHSQ
     ASSTKAQTQF LHQTLGSILA LLCKTQKGDP YFSFLNAVLM KCVLTQHTLD VLLLTKKDSS
     MTLCSLLNAI SFEPINLKAI PLFFIICADS INFHLSSVEK SISQQKASEL MYKLFSEHIA
     FLLSLKNLPE EATLDCMLSI CQVFENDNLH RGHSDEYTFA MLEQLLELSV KTLRQNTCWS
     TSWEMLSSLL AIDFDVLLPH SKILWECIKS VSHQDDIHAL KFLKRWVRAS AKARILDSFC
     IDWHLNVQTM SERSILTNRD FITSFSAVAE VSLSQISIKK LVTWLMSSES IMSENSNRFV
     VYYSLCKSLK RESYPAHLVP NFELFTRSIF NASLKNFNIL DERSQALLCM CQISHVQFFS
     SDMSISASVG MKTLFEDLMA EKSRGLSSTV WSLQLLLCYL EQCLRLNTLH EDTTFPMRVV
     NYALEYSSKA LDKFAENSHL ILLDMVDVGK PDLVLTLLCR WLHMVHLYSS RTSITSWIYS
     IASKFYFIDS LNLETKDSVL ESNWERFISS TETYELDSIR DSLIDCLIRL LCYSSNNAID
     PVSAPGNLDF DNSAELCSSL TRFTPKNIDF VLKSLIHIPI HSITKNQRTR LLNLLIIHEK
     LLSDKDNSAH ISLRKIIYTL MKTPCSSGFY RDPKIIIDLM QFGKTDLSFH KVHVLIMRSW
     IQHLDEGNKS EVILKLLQLI LADFRELPLE TITLIFNALV DSLPTSKHIK NSNDILSSVF
     TINDMLIDEM TAYLSKKESL CSGTFSCLLA CCNSVLRTQN LTSESLNKLH ILKVGIEEKA
     ISLKLNELPF LENWILFQCL LSFGGDDFLK VVAYMVYYRR TVGEMSFRVS DFELALSRLS
     TNDADYAILN ILNLLTSNEC DEFDYSVLMK VVGVFANYSD CFQRNRHLVH MVLLCCTHVF
     YNQTLKPATL IDSALDVFLC FVQKTSKFIS LDSFNTILTA LSTILNLKEL ECEPKDHANL
     ILKIIQILNG LLFNHRSYMS GRFHVFYSIL KSLLYSMVQH DSEMKKIKGI ALMNFYKPKK
     VPIHVVQSFC RLLTTWMNPN LMHDSNKKNS SLTDAERLFV KATTKHFVFL LTDFMSAQTV
     YQIDIQVKEL LTNCFYNVYE NLSNHEKQMA LVAMNAPSKS LYQKFVNDYL IFAKWNEA