ID   URC2_LACKL              Reviewed;         726 AA.
AC   Q6YFE6;
DT   24-MAR-2009, integrated into UniProtKB/Swiss-Prot.
DT   21-SEP-2011, sequence version 2.
DT   25-MAY-2022, entry version 63.
DE   RecName: Full=Uracil catabolism protein 2;
GN   Name=URC2;
OS   Lachancea kluyveri (Yeast) (Saccharomyces kluyveri).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Saccharomycetaceae; Lachancea.
OX   NCBI_TaxID=4934;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND FUNCTION.
RX   PubMed=18550080; DOI=10.1016/j.jmb.2008.05.029;
RA   Andersen G., Bjoernberg O., Polakova S., Pynyaha Y., Rasmussen A.,
RA   Moeller K., Hofer A., Moritz T., Sandrini M.P., Merico A.M., Compagno C.,
RA   Aekerlund H.E., Gojkovic Z., Piskur J.;
RT   "A second pathway to degrade pyrimidine nucleic acid precursors in
RT   eukaryotes.";
RL   J. Mol. Biol. 380:656-666(2008).
RN   [2]
RP   SEQUENCE REVISION TO 280 AND 436.
RA   Rasmussen A., Piskur J.;
RL   Submitted (NOV-2010) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Probable transcriptional activator involved in uracil
CC       catabolism. {ECO:0000269|PubMed:18550080}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the URC2 family. {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; AY154653; AAO06875.2; -; Genomic_DNA.
DR   AlphaFoldDB; Q6YFE6; -.
DR   SMR; Q6YFE6; -.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IEA:InterPro.
DR   GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR   GO; GO:0009117; P:nucleotide metabolic process; IEA:UniProtKB-KW.
DR   CDD; cd00067; GAL4; 1.
DR   Gene3D; 4.10.240.10; -; 1.
DR   InterPro; IPR001138; Zn2-C6_fun-type_DNA-bd.
DR   InterPro; IPR036864; Zn2-C6_fun-type_DNA-bd_sf.
DR   SMART; SM00066; GAL4; 1.
DR   SUPFAM; SSF57701; SSF57701; 1.
DR   PROSITE; PS00463; ZN2_CY6_FUNGAL_1; 1.
PE   3: Inferred from homology;
KW   Activator; DNA-binding; Metal-binding; Nucleotide metabolism; Nucleus;
KW   Transcription; Transcription regulation; Zinc.
FT   CHAIN           1..726
FT                   /note="Uracil catabolism protein 2"
FT                   /id="PRO_0000367586"
FT   DNA_BIND        24..53
FT                   /note="Zn(2)-C6 fungal-type"
FT   REGION          152..183
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          629..681
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        639..681
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   726 AA;  82079 MW;  698812063449BCAD CRC64;
     MASDNSQTQT RTKKPRKKRK TYSCGVCRKF KTRCDFEPLV GKCHRCNVLR LECSLTKERE
     EEILAAVEST SKSTLAPASL VSGQLPALAA ANPVVANDAV VVAPVAATLS SRLNKLESSV
     GSLNSKLDLA LMLLQGSNSA ISNLKNLTSS KAGMGDRNAT YDDDDDGDDD GHDHSDSDNF
     VNGIKLQEPP LKLISDIDER LFPTKAQSQQ DILAKTQRPF VVARFNFLKY FNQHEQLCLD
     LSRDFLVKSH FWIIPGGIKE INRTYVEKHL FITSVFTIIA MGFDENNKYE KEQEQLYPLV
     ERFLTNTLTM FEKLTDHDIE AILYCSMFNI SRKSKRHRQL KFNSLVLCNF AVNSVLNIVD
     FHKIKERVLI NEEYSALDLY HLRILNSLTA CRLQYSIGSG NFTIQDDMLK EFNNLTAKFP
     QANFGDDIKI SEINLGDIVN GIFLNFKAYF KGFSKRFRAE TRGHADRNRD CLVIPELEYW
     LKNWDELLSK DGGGVLLFAY DFYYSMICRS FLTEFFEEEF QNDVVYFKCA LKTMKRYCFS
     LLDGFLKLPP SLIKGAPTIT LHQLVYACLT LCDFLHCFDV AERQQVLNLC TKIYWHLNTI
     GEKLNEATDN VGKIIKSLID TSKRKAQVSG RLAVPRNTKR GSPSMTPGFQ QSVQSSSALQ
     GSKAGSPQSA RSVNSQGSGA DSLAAASFNM PDVAQFNSFE DFFQDFFDNL KPTTQSMFST
     LQQQQQ