ID   URE23_CAMLA             Reviewed;         223 AA.
AC   Q5FB24;
DT   02-MAY-2006, integrated into UniProtKB/Swiss-Prot.
DT   15-MAR-2005, sequence version 1.
DT   25-MAY-2022, entry version 62.
DE   RecName: Full=Urease subunit alpha {ECO:0000255|HAMAP-Rule:MF_01955};
DE            EC=3.5.1.5 {ECO:0000255|HAMAP-Rule:MF_01955};
DE   AltName: Full=Urea amidohydrolase subunit alpha {ECO:0000255|HAMAP-Rule:MF_01955};
GN   Name=ureA {ECO:0000255|HAMAP-Rule:MF_01955};
OS   Campylobacter lari.
OC   Bacteria; Proteobacteria; Epsilonproteobacteria; Campylobacterales;
OC   Campylobacteraceae; Campylobacter.
OX   NCBI_TaxID=201;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=CF89-12;
RX   PubMed=16798085; DOI=10.1016/j.ijheh.2005.09.010;
RA   Usui K., Iida H., Ueno H., Sekizuka T., Matsuda M., Murayama O.,
RA   Cherie Millar B., Moore J.E.;
RT   "Genetic heterogeneity of urease gene loci in urease-positive thermophilic
RT   Campylobacter (UPTC).";
RL   Int. J. Hyg. Environ. Health 209:541-545(2006).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=2 H(+) + H2O + urea = CO2 + 2 NH4(+); Xref=Rhea:RHEA:20557,
CC         ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:16199,
CC         ChEBI:CHEBI:16526, ChEBI:CHEBI:28938; EC=3.5.1.5;
CC         Evidence={ECO:0000255|HAMAP-Rule:MF_01955};
CC   -!- PATHWAY: Nitrogen metabolism; urea degradation; CO(2) and NH(3) from
CC       urea (urease route): step 1/1. {ECO:0000255|HAMAP-Rule:MF_01955}.
CC   -!- SUBUNIT: Heterohexamer of 3 UreA (alpha) and 3 UreB (beta) subunits.
CC       {ECO:0000255|HAMAP-Rule:MF_01955}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_01955}.
CC   -!- SIMILARITY: In the N-terminal section; belongs to the urease gamma
CC       subunit family. {ECO:0000255|HAMAP-Rule:MF_01955}.
CC   -!- SIMILARITY: In the C-terminal section; belongs to the urease beta
CC       subunit family. {ECO:0000255|HAMAP-Rule:MF_01955}.
CC   -!- CAUTION: The orthologous protein is known as the gamma/beta subunit
CC       (UreAB) in most other bacteria. {ECO:0000305}.
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DR   EMBL; AB201709; BAD89501.1; -; Genomic_DNA.
DR   RefSeq; WP_039617037.1; NZ_LR134508.1.
DR   AlphaFoldDB; Q5FB24; -.
DR   SMR; Q5FB24; -.
DR   OrthoDB; 1755809at2; -.
DR   UniPathway; UPA00258; UER00370.
DR   GO; GO:0035550; C:urease complex; IEA:InterPro.
DR   GO; GO:0016151; F:nickel cation binding; IEA:InterPro.
DR   GO; GO:0009039; F:urease activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0043419; P:urea catabolic process; IEA:UniProtKB-UniPathway.
DR   CDD; cd00407; Urease_beta; 1.
DR   CDD; cd00390; Urease_gamma; 1.
DR   Gene3D; 2.10.150.10; -; 1.
DR   Gene3D; 3.30.280.10; -; 1.
DR   HAMAP; MF_01954; Urease_beta; 1.
DR   HAMAP; MF_01955; Urease_beta_gamma; 1.
DR   InterPro; IPR002019; Urease_beta.
DR   InterPro; IPR036461; Urease_betasu_sf.
DR   InterPro; IPR008223; Urease_gamma-beta_su.
DR   InterPro; IPR002026; Urease_gamma/gamma-beta_su.
DR   InterPro; IPR036463; Urease_gamma_sf.
DR   Pfam; PF00699; Urease_beta; 1.
DR   Pfam; PF00547; Urease_gamma; 1.
DR   PIRSF; PIRSF001225; Urease_gammabeta; 1.
DR   SUPFAM; SSF51278; SSF51278; 1.
DR   SUPFAM; SSF54111; SSF54111; 1.
DR   TIGRFAMs; TIGR00192; urease_beta; 1.
DR   TIGRFAMs; TIGR00193; urease_gam; 1.
PE   3: Inferred from homology;
KW   Cytoplasm; Hydrolase.
FT   CHAIN           1..223
FT                   /note="Urease subunit alpha"
FT                   /id="PRO_0000234196"
FT   REGION          1..101
FT                   /note="Urease gamma"
FT   REGION          102..223
FT                   /note="Urease beta"
SQ   SEQUENCE   223 AA;  25341 MW;  E23605DABBD3E948 CRC64;
     MHFTQQQLQR LMLHYAGKIA KDRKEQKIKL NYNEALAYIC YELMELARKN LSVSELMSIG
     KTLLTSEDVI DGVASMLDEI QIELPFEDGT KLVTIHEPIA NDDKIKAGEI FLSSEFIVLN
     ENKTSIEIKV SNKGDRPIQV GSHFHFFEVN RFLSFDREKA YGKRLNIASG TSVRFEPGEE
     KTVSLIEFGG LKKVLGFNNL CDDFINDENK TKALSKAKEK GFL