URE23_DEIRA
ID URE23_DEIRA Reviewed; 228 AA.
AC Q9RYJ3;
DT 16-JAN-2004, integrated into UniProtKB/Swiss-Prot.
DT 01-MAY-2000, sequence version 1.
DT 25-MAY-2022, entry version 117.
DE RecName: Full=Urease subunit gamma/beta {ECO:0000255|HAMAP-Rule:MF_01955};
DE EC=3.5.1.5 {ECO:0000255|HAMAP-Rule:MF_01955};
DE AltName: Full=Urea amidohydrolase subunit gamma/beta {ECO:0000255|HAMAP-Rule:MF_01955};
GN Name=ureAB {ECO:0000255|HAMAP-Rule:MF_01955}; OrderedLocusNames=DR_A0319;
OS Deinococcus radiodurans (strain ATCC 13939 / DSM 20539 / JCM 16871 / LMG
OS 4051 / NBRC 15346 / NCIMB 9279 / R1 / VKM B-1422).
OC Bacteria; Deinococcus-Thermus; Deinococci; Deinococcales; Deinococcaceae;
OC Deinococcus.
OX NCBI_TaxID=243230;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 13939 / DSM 20539 / JCM 16871 / LMG 4051 / NBRC 15346 / NCIMB
RC 9279 / R1 / VKM B-1422;
RX PubMed=10567266; DOI=10.1126/science.286.5444.1571;
RA White O., Eisen J.A., Heidelberg J.F., Hickey E.K., Peterson J.D.,
RA Dodson R.J., Haft D.H., Gwinn M.L., Nelson W.C., Richardson D.L.,
RA Moffat K.S., Qin H., Jiang L., Pamphile W., Crosby M., Shen M.,
RA Vamathevan J.J., Lam P., McDonald L.A., Utterback T.R., Zalewski C.,
RA Makarova K.S., Aravind L., Daly M.J., Minton K.W., Fleischmann R.D.,
RA Ketchum K.A., Nelson K.E., Salzberg S.L., Smith H.O., Venter J.C.,
RA Fraser C.M.;
RT "Genome sequence of the radioresistant bacterium Deinococcus radiodurans
RT R1.";
RL Science 286:1571-1577(1999).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=2 H(+) + H2O + urea = CO2 + 2 NH4(+); Xref=Rhea:RHEA:20557,
CC ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:16199,
CC ChEBI:CHEBI:16526, ChEBI:CHEBI:28938; EC=3.5.1.5;
CC Evidence={ECO:0000255|HAMAP-Rule:MF_01955};
CC -!- PATHWAY: Nitrogen metabolism; urea degradation; CO(2) and NH(3) from
CC urea (urease route): step 1/1. {ECO:0000255|HAMAP-Rule:MF_01955}.
CC -!- SUBUNIT: Heterohexamer of 3 UreC (alpha) and 3 UreAB (gamma/beta)
CC subunits. {ECO:0000255|HAMAP-Rule:MF_01955}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_01955}.
CC -!- SIMILARITY: In the N-terminal section; belongs to the urease gamma
CC subunit family. {ECO:0000255|HAMAP-Rule:MF_01955}.
CC -!- SIMILARITY: In the C-terminal section; belongs to the urease beta
CC subunit family. {ECO:0000255|HAMAP-Rule:MF_01955}.
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DR EMBL; AE001825; AAF12460.1; -; Genomic_DNA.
DR PIR; D75586; D75586.
DR RefSeq; NP_285642.1; NC_001264.1.
DR RefSeq; WP_010889578.1; NZ_CP015082.1.
DR AlphaFoldDB; Q9RYJ3; -.
DR SMR; Q9RYJ3; -.
DR STRING; 243230.DR_A0319; -.
DR PRIDE; Q9RYJ3; -.
DR EnsemblBacteria; AAF12460; AAF12460; DR_A0319.
DR KEGG; dra:DR_A0319; -.
DR PATRIC; fig|243230.17.peg.3209; -.
DR eggNOG; COG0831; Bacteria.
DR eggNOG; COG0832; Bacteria.
DR HOGENOM; CLU_000980_3_0_0; -.
DR InParanoid; Q9RYJ3; -.
DR OMA; DNTGDRP; -.
DR OrthoDB; 1755809at2; -.
DR UniPathway; UPA00258; UER00370.
DR Proteomes; UP000002524; Chromosome II.
DR GO; GO:0035550; C:urease complex; IEA:InterPro.
DR GO; GO:0016151; F:nickel cation binding; IEA:InterPro.
DR GO; GO:0009039; F:urease activity; IEA:UniProtKB-UniRule.
DR GO; GO:0043419; P:urea catabolic process; IEA:UniProtKB-UniPathway.
DR CDD; cd00407; Urease_beta; 1.
DR CDD; cd00390; Urease_gamma; 1.
DR Gene3D; 2.10.150.10; -; 1.
DR Gene3D; 3.30.280.10; -; 1.
DR HAMAP; MF_01954; Urease_beta; 1.
DR HAMAP; MF_01955; Urease_beta_gamma; 1.
DR HAMAP; MF_00739; Urease_gamma; 1.
DR InterPro; IPR002019; Urease_beta.
DR InterPro; IPR036461; Urease_betasu_sf.
DR InterPro; IPR012010; Urease_gamma.
DR InterPro; IPR008223; Urease_gamma-beta_su.
DR InterPro; IPR002026; Urease_gamma/gamma-beta_su.
DR InterPro; IPR036463; Urease_gamma_sf.
DR Pfam; PF00699; Urease_beta; 1.
DR Pfam; PF00547; Urease_gamma; 1.
DR PIRSF; PIRSF001225; Urease_gammabeta; 1.
DR SUPFAM; SSF51278; SSF51278; 1.
DR SUPFAM; SSF54111; SSF54111; 1.
DR TIGRFAMs; TIGR00192; urease_beta; 1.
DR TIGRFAMs; TIGR00193; urease_gam; 1.
PE 3: Inferred from homology;
KW Cytoplasm; Hydrolase; Reference proteome.
FT CHAIN 1..228
FT /note="Urease subunit gamma/beta"
FT /id="PRO_0000098076"
FT REGION 1..101
FT /note="Urease gamma"
FT REGION 102..228
FT /note="Urease beta"
SQ SEQUENCE 228 AA; 24521 MW; 257CCEA909C8D0A2 CRC64;
MQLTERERDK LLIFTAAQLA RERRARGLKL NHPEAVALIT AEVLEGIRDG RRVEDLMSFG
AAILTPDDVL DGVPELIHEI QVEGTFPDGT KLVTVHDPIR GAASRRVAGE YLLEGGEIEL
NAGRPVTTLT VANTADRPVQ VGSHFHFFEV NAGLRFDRAA AYGFRLNIPA GTAVRFEPGE
EREVDLVPLG GSRTVYGMNA LVNGDLDAPG TREAALEGAR AAGFGGAQ
