ID   URE23_HELHE             Reviewed;         234 AA.
AC   P42822;
DT   01-NOV-1995, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1995, sequence version 1.
DT   25-MAY-2022, entry version 90.
DE   RecName: Full=Urease subunit alpha {ECO:0000255|HAMAP-Rule:MF_01955};
DE            EC=3.5.1.5 {ECO:0000255|HAMAP-Rule:MF_01955};
DE   AltName: Full=Urea amidohydrolase subunit alpha {ECO:0000255|HAMAP-Rule:MF_01955};
GN   Name=ureA {ECO:0000255|HAMAP-Rule:MF_01955};
OS   Helicobacter heilmannii.
OC   Bacteria; Proteobacteria; Epsilonproteobacteria; Campylobacterales;
OC   Helicobacteraceae; Helicobacter.
OX   NCBI_TaxID=35817;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=2;
RX   PubMed=8168924; DOI=10.1128/iai.62.5.1631-1638.1994;
RA   Solnick J.V., O'Rourke J., Lee A., Tompkins L.S.;
RT   "Molecular analysis of urease genes from a newly identified uncultured
RT   species of Helicobacter.";
RL   Infect. Immun. 62:1631-1638(1994).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=2 H(+) + H2O + urea = CO2 + 2 NH4(+); Xref=Rhea:RHEA:20557,
CC         ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:16199,
CC         ChEBI:CHEBI:16526, ChEBI:CHEBI:28938; EC=3.5.1.5;
CC         Evidence={ECO:0000255|HAMAP-Rule:MF_01955};
CC   -!- PATHWAY: Nitrogen metabolism; urea degradation; CO(2) and NH(3) from
CC       urea (urease route): step 1/1. {ECO:0000255|HAMAP-Rule:MF_01955}.
CC   -!- SUBUNIT: Heterohexamer of 3 UreA (alpha) and 3 UreB (beta) subunits.
CC       {ECO:0000255|HAMAP-Rule:MF_01955}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_01955}.
CC   -!- SIMILARITY: In the N-terminal section; belongs to the urease gamma
CC       subunit family. {ECO:0000255|HAMAP-Rule:MF_01955}.
CC   -!- SIMILARITY: In the C-terminal section; belongs to the urease beta
CC       subunit family. {ECO:0000255|HAMAP-Rule:MF_01955}.
CC   -!- CAUTION: The orthologous protein is known as the gamma/beta subunit
CC       (UreAB) in most other bacteria. {ECO:0000305}.
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DR   EMBL; L25079; AAA65722.1; -; Genomic_DNA.
DR   AlphaFoldDB; P42822; -.
DR   SMR; P42822; -.
DR   UniPathway; UPA00258; UER00370.
DR   GO; GO:0035550; C:urease complex; IEA:InterPro.
DR   GO; GO:0016151; F:nickel cation binding; IEA:InterPro.
DR   GO; GO:0009039; F:urease activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0043419; P:urea catabolic process; IEA:UniProtKB-UniPathway.
DR   CDD; cd00407; Urease_beta; 1.
DR   CDD; cd00390; Urease_gamma; 1.
DR   Gene3D; 2.10.150.10; -; 1.
DR   Gene3D; 3.30.280.10; -; 1.
DR   HAMAP; MF_01954; Urease_beta; 1.
DR   HAMAP; MF_01955; Urease_beta_gamma; 1.
DR   InterPro; IPR002019; Urease_beta.
DR   InterPro; IPR036461; Urease_betasu_sf.
DR   InterPro; IPR008223; Urease_gamma-beta_su.
DR   InterPro; IPR002026; Urease_gamma/gamma-beta_su.
DR   InterPro; IPR036463; Urease_gamma_sf.
DR   Pfam; PF00699; Urease_beta; 1.
DR   Pfam; PF00547; Urease_gamma; 1.
DR   PIRSF; PIRSF001225; Urease_gammabeta; 1.
DR   SUPFAM; SSF51278; SSF51278; 1.
DR   SUPFAM; SSF54111; SSF54111; 1.
DR   TIGRFAMs; TIGR00192; urease_beta; 1.
DR   TIGRFAMs; TIGR00193; urease_gam; 1.
PE   3: Inferred from homology;
KW   Cytoplasm; Hydrolase.
FT   CHAIN           1..234
FT                   /note="Urease subunit alpha"
FT                   /id="PRO_0000098071"
FT   REGION          1..102
FT                   /note="Urease gamma"
FT   REGION          103..234
FT                   /note="Urease beta"
SQ   SEQUENCE   234 AA;  25746 MW;  CD5889E3D789C7F8 CRC64;
     MKLTPKELDK LMLHYAGELA KQRKAKGIKL NYTEAVALIS AHVMEEARAG KKSVADLMQE
     GRTLLKADDV MPGVAHMIHE VGIEAGFPDG TKLVTIHTPV EAGSDKLAPG EVILKNEDIT
     LNAGKHAVQL KVKNKGDRPV QVGSHFHFFE VNKLLDFDRE KAYGKRLDIA SGTAVRFEPG
     EEKTVELIDI GGNKRIYGFN ALVDRQADHD GKKLALKRAK EKHFGTINCG CDNK