URE23_HELHP
ID URE23_HELHP Reviewed; 225 AA.
AC Q93PJ5; Q9R8R2; Q9R8R4; Q9ZHF2;
DT 16-JAN-2004, integrated into UniProtKB/Swiss-Prot.
DT 01-DEC-2001, sequence version 1.
DT 25-MAY-2022, entry version 115.
DE RecName: Full=Urease subunit alpha {ECO:0000255|HAMAP-Rule:MF_01955};
DE EC=3.5.1.5 {ECO:0000255|HAMAP-Rule:MF_01955};
DE AltName: Full=Urea amidohydrolase subunit alpha {ECO:0000255|HAMAP-Rule:MF_01955};
GN Name=ureA {ECO:0000255|HAMAP-Rule:MF_01955}; OrderedLocusNames=HH_0407;
OS Helicobacter hepaticus (strain ATCC 51449 / 3B1).
OC Bacteria; Proteobacteria; Epsilonproteobacteria; Campylobacterales;
OC Helicobacteraceae; Helicobacter.
OX NCBI_TaxID=235279;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=MU94-1;
RX PubMed=11500473; DOI=10.1128/iai.69.9.5914-5920.2001;
RA Beckwith C.S., McGee D.J., Mobley H.L.T., Riley L.K.;
RT "Cloning, expression, and catalytic activity of Helicobacter hepaticus
RT urease.";
RL Infect. Immun. 69:5914-5920(2001).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 51449 / 3B1;
RX PubMed=12810954; DOI=10.1073/pnas.1332093100;
RA Suerbaum S., Josenhans C., Sterzenbach T., Drescher B., Brandt P., Bell M.,
RA Droege M., Fartmann B., Fischer H.-P., Ge Z., Hoerster A., Holland R.,
RA Klein K., Koenig J., Macko L., Mendz G.L., Nyakatura G., Schauer D.B.,
RA Shen Z., Weber J., Frosch M., Fox J.G.;
RT "The complete genome sequence of the carcinogenic bacterium Helicobacter
RT hepaticus.";
RL Proc. Natl. Acad. Sci. U.S.A. 100:7901-7906(2003).
RN [3]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 4-225.
RC STRAIN=ATCC 51449 / 3B1, MIT 95-1971, and MIT 96-284;
RX PubMed=9705372; DOI=10.1128/jcm.36.9.2447-2453.1998;
RA Shen Z., Schauer D.B., Mobley H.L.T., Fox J.G.;
RT "Development of a PCR-restriction fragment length polymorphism assay using
RT the nucleotide sequence of the Helicobacter hepaticus urease structural
RT genes ureAB.";
RL J. Clin. Microbiol. 36:2447-2453(1998).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=2 H(+) + H2O + urea = CO2 + 2 NH4(+); Xref=Rhea:RHEA:20557,
CC ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:16199,
CC ChEBI:CHEBI:16526, ChEBI:CHEBI:28938; EC=3.5.1.5;
CC Evidence={ECO:0000255|HAMAP-Rule:MF_01955};
CC -!- PATHWAY: Nitrogen metabolism; urea degradation; CO(2) and NH(3) from
CC urea (urease route): step 1/1. {ECO:0000255|HAMAP-Rule:MF_01955}.
CC -!- SUBUNIT: Heterohexamer of 3 UreA (alpha) and 3 UreB (beta) subunits.
CC {ECO:0000255|HAMAP-Rule:MF_01955}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_01955}.
CC -!- SIMILARITY: In the N-terminal section; belongs to the urease gamma
CC subunit family. {ECO:0000255|HAMAP-Rule:MF_01955}.
CC -!- SIMILARITY: In the C-terminal section; belongs to the urease beta
CC subunit family. {ECO:0000255|HAMAP-Rule:MF_01955}.
CC -!- CAUTION: The orthologous protein is known as the gamma/beta subunit
CC (UreAB) in most other bacteria. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAC72748.1; Type=Erroneous initiation; Evidence={ECO:0000305};
CC Sequence=AAC72750.1; Type=Erroneous initiation; Evidence={ECO:0000305};
CC Sequence=AAC72752.1; Type=Erroneous initiation; Evidence={ECO:0000305};
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AF332656; AAK69198.1; -; Genomic_DNA.
DR EMBL; AE017125; AAP77004.1; -; Genomic_DNA.
DR EMBL; AF066862; AAC72748.1; ALT_INIT; Genomic_DNA.
DR EMBL; AF066863; AAC72750.1; ALT_INIT; Genomic_DNA.
DR EMBL; AF066864; AAC72752.1; ALT_INIT; Genomic_DNA.
DR RefSeq; WP_011115249.1; NC_004917.1.
DR AlphaFoldDB; Q93PJ5; -.
DR SMR; Q93PJ5; -.
DR STRING; 235279.HH_0407; -.
DR EnsemblBacteria; AAP77004; AAP77004; HH_0407.
DR KEGG; hhe:HH_0407; -.
DR eggNOG; COG0831; Bacteria.
DR eggNOG; COG0832; Bacteria.
DR HOGENOM; CLU_000980_3_0_7; -.
DR OMA; DNTGDRP; -.
DR OrthoDB; 1755809at2; -.
DR BRENDA; 3.5.1.5; 7587.
DR UniPathway; UPA00258; UER00370.
DR Proteomes; UP000002495; Chromosome.
DR GO; GO:0035550; C:urease complex; IEA:InterPro.
DR GO; GO:0016151; F:nickel cation binding; IEA:InterPro.
DR GO; GO:0009039; F:urease activity; IEA:UniProtKB-UniRule.
DR GO; GO:0071281; P:cellular response to iron ion; IEP:CollecTF.
DR GO; GO:0043419; P:urea catabolic process; IEA:UniProtKB-UniPathway.
DR CDD; cd00407; Urease_beta; 1.
DR CDD; cd00390; Urease_gamma; 1.
DR Gene3D; 2.10.150.10; -; 1.
DR Gene3D; 3.30.280.10; -; 1.
DR HAMAP; MF_01954; Urease_beta; 1.
DR HAMAP; MF_01955; Urease_beta_gamma; 1.
DR InterPro; IPR002019; Urease_beta.
DR InterPro; IPR036461; Urease_betasu_sf.
DR InterPro; IPR008223; Urease_gamma-beta_su.
DR InterPro; IPR002026; Urease_gamma/gamma-beta_su.
DR InterPro; IPR036463; Urease_gamma_sf.
DR Pfam; PF00699; Urease_beta; 1.
DR Pfam; PF00547; Urease_gamma; 1.
DR PIRSF; PIRSF001225; Urease_gammabeta; 1.
DR SUPFAM; SSF51278; SSF51278; 1.
DR SUPFAM; SSF54111; SSF54111; 1.
DR TIGRFAMs; TIGR00192; urease_beta; 1.
DR TIGRFAMs; TIGR00193; urease_gam; 1.
PE 3: Inferred from homology;
KW Cytoplasm; Hydrolase; Reference proteome.
FT CHAIN 1..225
FT /note="Urease subunit alpha"
FT /id="PRO_0000098072"
FT REGION 1..102
FT /note="Urease gamma"
FT REGION 103..225
FT /note="Urease beta"
FT CONFLICT 79
FT /note="N -> D (in Ref. 3; AAC72750/AAC72752)"
FT /evidence="ECO:0000305"
FT CONFLICT 104
FT /note="G -> S (in Ref. 3; AAC72750)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 225 AA; 25198 MW; 6EE86B6CAEF2C508 CRC64;
MRLTPKELDK LMLHYAGALA KSRKERGIKL NYVESIALIS MEIMELAREG NKSVAELMQQ
GREILKADEV MEGVASMVNE VQVEVSFPDG TKLVTIHNPI EDNGKLTPGE YILKDEDITL
NANKESISIK VTHKGDRPIQ VGSHFHFFEV NALLEFDRAQ AFGKRLDIAS GTSVRFEPGE
EKNVNLIDFG GKQKIIGFND LTNAHINKEN KEQCLANAAQ KHFIH
