URE23_HELPS
ID URE23_HELPS Reviewed; 238 AA.
AC B2UW71;
DT 28-JUL-2009, integrated into UniProtKB/Swiss-Prot.
DT 01-JUL-2008, sequence version 1.
DT 25-MAY-2022, entry version 71.
DE RecName: Full=Urease subunit alpha {ECO:0000255|HAMAP-Rule:MF_01955};
DE EC=3.5.1.5 {ECO:0000255|HAMAP-Rule:MF_01955};
DE AltName: Full=Urea amidohydrolase subunit alpha {ECO:0000255|HAMAP-Rule:MF_01955};
GN Name=ureA {ECO:0000255|HAMAP-Rule:MF_01955}; OrderedLocusNames=HPSH_00355;
OS Helicobacter pylori (strain Shi470).
OC Bacteria; Proteobacteria; Epsilonproteobacteria; Campylobacterales;
OC Helicobacteraceae; Helicobacter.
OX NCBI_TaxID=512562;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Shi470;
RA Kersulyte D., Kalia A., Gilman R.H., Berg D.E.;
RT "Genome sequence of Helicobacter pylori from the remote Amazon: traces of
RT Asian ancestry of the first Americans.";
RL Submitted (MAY-2008) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=2 H(+) + H2O + urea = CO2 + 2 NH4(+); Xref=Rhea:RHEA:20557,
CC ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:16199,
CC ChEBI:CHEBI:16526, ChEBI:CHEBI:28938; EC=3.5.1.5;
CC Evidence={ECO:0000255|HAMAP-Rule:MF_01955};
CC -!- PATHWAY: Nitrogen metabolism; urea degradation; CO(2) and NH(3) from
CC urea (urease route): step 1/1. {ECO:0000255|HAMAP-Rule:MF_01955}.
CC -!- SUBUNIT: Heterohexamer of 3 UreA (alpha) and 3 UreB (beta) subunits.
CC {ECO:0000255|HAMAP-Rule:MF_01955}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_01955}.
CC -!- SIMILARITY: In the N-terminal section; belongs to the urease gamma
CC subunit family. {ECO:0000255|HAMAP-Rule:MF_01955}.
CC -!- SIMILARITY: In the C-terminal section; belongs to the urease beta
CC subunit family. {ECO:0000255|HAMAP-Rule:MF_01955}.
CC -!- CAUTION: The orthologous protein is known as the gamma/beta subunit
CC (UreAB) in most other bacteria. {ECO:0000305}.
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DR EMBL; CP001072; ACD47536.1; -; Genomic_DNA.
DR RefSeq; WP_000779238.1; NC_010698.2.
DR AlphaFoldDB; B2UW71; -.
DR SMR; B2UW71; -.
DR KEGG; hps:HPSH_00355; -.
DR HOGENOM; CLU_000980_3_0_7; -.
DR OMA; DNTGDRP; -.
DR UniPathway; UPA00258; UER00370.
DR GO; GO:0035550; C:urease complex; IEA:InterPro.
DR GO; GO:0016151; F:nickel cation binding; IEA:InterPro.
DR GO; GO:0009039; F:urease activity; IEA:UniProtKB-UniRule.
DR GO; GO:0043419; P:urea catabolic process; IEA:UniProtKB-UniPathway.
DR CDD; cd00407; Urease_beta; 1.
DR CDD; cd00390; Urease_gamma; 1.
DR Gene3D; 2.10.150.10; -; 1.
DR Gene3D; 3.30.280.10; -; 1.
DR HAMAP; MF_01954; Urease_beta; 1.
DR HAMAP; MF_01955; Urease_beta_gamma; 1.
DR InterPro; IPR002019; Urease_beta.
DR InterPro; IPR036461; Urease_betasu_sf.
DR InterPro; IPR008223; Urease_gamma-beta_su.
DR InterPro; IPR002026; Urease_gamma/gamma-beta_su.
DR InterPro; IPR036463; Urease_gamma_sf.
DR Pfam; PF00699; Urease_beta; 1.
DR Pfam; PF00547; Urease_gamma; 1.
DR PIRSF; PIRSF001225; Urease_gammabeta; 1.
DR SUPFAM; SSF51278; SSF51278; 1.
DR SUPFAM; SSF54111; SSF54111; 1.
DR TIGRFAMs; TIGR00192; urease_beta; 1.
DR TIGRFAMs; TIGR00193; urease_gam; 1.
PE 3: Inferred from homology;
KW Cytoplasm; Hydrolase.
FT CHAIN 1..238
FT /note="Urease subunit alpha"
FT /id="PRO_1000188949"
FT REGION 1..102
FT /note="Urease gamma"
FT REGION 103..238
FT /note="Urease beta"
SQ SEQUENCE 238 AA; 26514 MW; 395884C4157637E0 CRC64;
MKLTPKELDK LMLHYAGELA RKRKEKGIKL NYVEAVALIS AHIMEEARAG KKTAAELMQE
GRTLLKPDDV MDGVASMIHE VGIEAMFPDG TKLVTVHTPI EASGKLVPGE LFLKNEDITI
NEGKKAVSVK VKNVGDRPVQ IGSHFHFFEV NRCLDFDREK TFGKRLDIAS GTAVRFEPGE
EKSVELIDIG GSRRIFGFNA LVDRQADNES KKIALHRAKE RGFHGAKSDD NYVKTIKE
