ID   URE23_STRCO             Reviewed;         227 AA.
AC   O86507;
DT   16-JAN-2004, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1998, sequence version 1.
DT   25-MAY-2022, entry version 117.
DE   RecName: Full=Urease subunit gamma/beta {ECO:0000255|HAMAP-Rule:MF_01955};
DE            EC=3.5.1.5 {ECO:0000255|HAMAP-Rule:MF_01955};
DE   AltName: Full=Urea amidohydrolase subunit gamma/beta {ECO:0000255|HAMAP-Rule:MF_01955};
GN   Name=ureAB {ECO:0000255|HAMAP-Rule:MF_01955}; OrderedLocusNames=SCO5525;
GN   ORFNames=SC1C2.06;
OS   Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145).
OC   Bacteria; Actinobacteria; Streptomycetales; Streptomycetaceae;
OC   Streptomyces; Streptomyces albidoflavus group.
OX   NCBI_TaxID=100226;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC BAA-471 / A3(2) / M145;
RX   PubMed=12000953; DOI=10.1038/417141a;
RA   Bentley S.D., Chater K.F., Cerdeno-Tarraga A.-M., Challis G.L.,
RA   Thomson N.R., James K.D., Harris D.E., Quail M.A., Kieser H., Harper D.,
RA   Bateman A., Brown S., Chandra G., Chen C.W., Collins M., Cronin A.,
RA   Fraser A., Goble A., Hidalgo J., Hornsby T., Howarth S., Huang C.-H.,
RA   Kieser T., Larke L., Murphy L.D., Oliver K., O'Neil S., Rabbinowitsch E.,
RA   Rajandream M.A., Rutherford K.M., Rutter S., Seeger K., Saunders D.,
RA   Sharp S., Squares R., Squares S., Taylor K., Warren T., Wietzorrek A.,
RA   Woodward J.R., Barrell B.G., Parkhill J., Hopwood D.A.;
RT   "Complete genome sequence of the model actinomycete Streptomyces coelicolor
RT   A3(2).";
RL   Nature 417:141-147(2002).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=2 H(+) + H2O + urea = CO2 + 2 NH4(+); Xref=Rhea:RHEA:20557,
CC         ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:16199,
CC         ChEBI:CHEBI:16526, ChEBI:CHEBI:28938; EC=3.5.1.5;
CC         Evidence={ECO:0000255|HAMAP-Rule:MF_01955};
CC   -!- PATHWAY: Nitrogen metabolism; urea degradation; CO(2) and NH(3) from
CC       urea (urease route): step 1/1. {ECO:0000255|HAMAP-Rule:MF_01955}.
CC   -!- SUBUNIT: Heterohexamer of 3 UreC (alpha) and 3 UreAB (gamma/beta)
CC       subunits. {ECO:0000255|HAMAP-Rule:MF_01955}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_01955}.
CC   -!- SIMILARITY: In the N-terminal section; belongs to the urease gamma
CC       subunit family. {ECO:0000255|HAMAP-Rule:MF_01955}.
CC   -!- SIMILARITY: In the C-terminal section; belongs to the urease beta
CC       subunit family. {ECO:0000255|HAMAP-Rule:MF_01955}.
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DR   EMBL; AL939124; CAA19973.1; -; Genomic_DNA.
DR   PIR; T29055; T29055.
DR   RefSeq; NP_629659.1; NC_003888.3.
DR   RefSeq; WP_011030293.1; NZ_VNID01000011.1.
DR   AlphaFoldDB; O86507; -.
DR   SMR; O86507; -.
DR   STRING; 100226.SCO5525; -.
DR   GeneID; 1100965; -.
DR   KEGG; sco:SCO5525; -.
DR   PATRIC; fig|100226.15.peg.5612; -.
DR   eggNOG; COG0831; Bacteria.
DR   eggNOG; COG0832; Bacteria.
DR   HOGENOM; CLU_000980_3_0_11; -.
DR   InParanoid; O86507; -.
DR   OMA; DNTGDRP; -.
DR   PhylomeDB; O86507; -.
DR   UniPathway; UPA00258; UER00370.
DR   Proteomes; UP000001973; Chromosome.
DR   GO; GO:0035550; C:urease complex; IEA:InterPro.
DR   GO; GO:0016151; F:nickel cation binding; IEA:InterPro.
DR   GO; GO:0009039; F:urease activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0043419; P:urea catabolic process; IEA:UniProtKB-UniPathway.
DR   CDD; cd00407; Urease_beta; 1.
DR   CDD; cd00390; Urease_gamma; 1.
DR   Gene3D; 2.10.150.10; -; 1.
DR   Gene3D; 3.30.280.10; -; 1.
DR   HAMAP; MF_01955; Urease_beta_gamma; 1.
DR   InterPro; IPR002019; Urease_beta.
DR   InterPro; IPR036461; Urease_betasu_sf.
DR   InterPro; IPR008223; Urease_gamma-beta_su.
DR   InterPro; IPR002026; Urease_gamma/gamma-beta_su.
DR   InterPro; IPR036463; Urease_gamma_sf.
DR   Pfam; PF00699; Urease_beta; 1.
DR   Pfam; PF00547; Urease_gamma; 1.
DR   PIRSF; PIRSF001225; Urease_gammabeta; 1.
DR   SUPFAM; SSF51278; SSF51278; 1.
DR   SUPFAM; SSF54111; SSF54111; 1.
DR   TIGRFAMs; TIGR00193; urease_gam; 1.
PE   3: Inferred from homology;
KW   Cytoplasm; Hydrolase; Reference proteome.
FT   CHAIN           1..227
FT                   /note="Urease subunit gamma/beta"
FT                   /id="PRO_0000098079"
FT   REGION          1..101
FT                   /note="Urease gamma"
FT   REGION          102..227
FT                   /note="Urease beta"
SQ   SEQUENCE   227 AA;  23636 MW;  47BAB6335926E32A CRC64;
     MRLTPTERDR LLLFGAAELA RARRARGLRL NVPEATALIA DTVCEAARDG ARLAQAIERA
     RSVLGPDDVL PGVADVVTEV HVEAVFDDGS RLAVVADPVG GGGLGDDAPG ALLPGHDRPE
     PEAALRLPVT NTATVPVSVT SHFHFFEANP RLDFDRGRAY GMRLAVPAGS SVRFGPGERV
     EVGLVPIGGA RVAIGFAGLV DGPLDAPGAR EEALRRAAAC GYLGADR