ID   URE2_ECO57              Reviewed;         106 AA.
AC   Q8XAG1; Q7AFH6;
DT   02-MAY-2006, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2002, sequence version 1.
DT   03-AUG-2022, entry version 116.
DE   RecName: Full=Urease subunit beta {ECO:0000255|HAMAP-Rule:MF_01954};
DE            EC=3.5.1.5 {ECO:0000255|HAMAP-Rule:MF_01954};
DE   AltName: Full=Urea amidohydrolase subunit beta {ECO:0000255|HAMAP-Rule:MF_01954};
GN   Name=ureB1 {ECO:0000255|HAMAP-Rule:MF_01954};
GN   OrderedLocusNames=Z1144, ECs1323;
GN   and
GN   Name=ureB2 {ECO:0000255|HAMAP-Rule:MF_01954}; OrderedLocusNames=Z1583;
OS   Escherichia coli O157:H7.
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Escherichia.
OX   NCBI_TaxID=83334;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=O157:H7 / EDL933 / ATCC 700927 / EHEC;
RX   PubMed=11206551; DOI=10.1038/35054089;
RA   Perna N.T., Plunkett G. III, Burland V., Mau B., Glasner J.D., Rose D.J.,
RA   Mayhew G.F., Evans P.S., Gregor J., Kirkpatrick H.A., Posfai G.,
RA   Hackett J., Klink S., Boutin A., Shao Y., Miller L., Grotbeck E.J.,
RA   Davis N.W., Lim A., Dimalanta E.T., Potamousis K., Apodaca J.,
RA   Anantharaman T.S., Lin J., Yen G., Schwartz D.C., Welch R.A.,
RA   Blattner F.R.;
RT   "Genome sequence of enterohaemorrhagic Escherichia coli O157:H7.";
RL   Nature 409:529-533(2001).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=O157:H7 / Sakai / RIMD 0509952 / EHEC;
RX   PubMed=11258796; DOI=10.1093/dnares/8.1.11;
RA   Hayashi T., Makino K., Ohnishi M., Kurokawa K., Ishii K., Yokoyama K.,
RA   Han C.-G., Ohtsubo E., Nakayama K., Murata T., Tanaka M., Tobe T., Iida T.,
RA   Takami H., Honda T., Sasakawa C., Ogasawara N., Yasunaga T., Kuhara S.,
RA   Shiba T., Hattori M., Shinagawa H.;
RT   "Complete genome sequence of enterohemorrhagic Escherichia coli O157:H7 and
RT   genomic comparison with a laboratory strain K-12.";
RL   DNA Res. 8:11-22(2001).
RN   [3]
RP   ABSENCE OF UREASE.
RC   STRAIN=O157:H7 / Sakai / RIMD 0509952 / EHEC;
RX   PubMed=15470125; DOI=10.1099/mic.0.27280-0;
RA   Nakano M., Iida T., Honda T.;
RT   "Urease activity of enterohaemorrhagic Escherichia coli depends on a
RT   specific one-base substitution in ureD.";
RL   Microbiology 150:3483-3489(2004).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=2 H(+) + H2O + urea = CO2 + 2 NH4(+); Xref=Rhea:RHEA:20557,
CC         ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:16199,
CC         ChEBI:CHEBI:16526, ChEBI:CHEBI:28938; EC=3.5.1.5;
CC         Evidence={ECO:0000255|HAMAP-Rule:MF_01954};
CC   -!- PATHWAY: Nitrogen metabolism; urea degradation; CO(2) and NH(3) from
CC       urea (urease route): step 1/1. {ECO:0000255|HAMAP-Rule:MF_01954}.
CC   -!- SUBUNIT: Heterotrimer of UreA (gamma), UreB (beta) and UreC (alpha)
CC       subunits. Three heterotrimers associate to form the active enzyme.
CC       {ECO:0000255|HAMAP-Rule:MF_01954}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_01954}.
CC   -!- SIMILARITY: Belongs to the urease beta subunit family.
CC       {ECO:0000255|HAMAP-Rule:MF_01954}.
CC   -!- CAUTION: Neither O157 strain expresses urease due to a truncation of
CC       ureD, the last gene of the probable operon. Urease activity is restored
CC       in O157 / Sakai upon complementation with wild-type ureD.
CC       {ECO:0000305}.
CC   -!- CAUTION: This region of the chromosome is duplicated in strain O157:H7
CC       / EDL933 but not in O157:H7 / Sakai. {ECO:0000305}.
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DR   EMBL; AE005174; AAG55289.1; -; Genomic_DNA.
DR   EMBL; AE005174; AAG55698.1; -; Genomic_DNA.
DR   EMBL; BA000007; BAB34746.1; -; Genomic_DNA.
DR   PIR; C90794; C90794.
DR   PIR; E85603; E85603.
DR   RefSeq; NP_309350.1; NC_002695.1.
DR   RefSeq; WP_000612150.1; NZ_SWKA01000005.1.
DR   AlphaFoldDB; Q8XAG1; -.
DR   SMR; Q8XAG1; -.
DR   STRING; 155864.EDL933_1043; -.
DR   EnsemblBacteria; AAG55289; AAG55289; Z1144.
DR   EnsemblBacteria; AAG55698; AAG55698; Z1583.
DR   EnsemblBacteria; BAB34746; BAB34746; ECs_1323.
DR   GeneID; 913707; -.
DR   KEGG; ece:Z1144; -.
DR   KEGG; ece:Z1583; -.
DR   KEGG; ecs:ECs_1323; -.
DR   PATRIC; fig|386585.9.peg.1428; -.
DR   eggNOG; COG0832; Bacteria.
DR   HOGENOM; CLU_129707_1_1_6; -.
DR   OMA; FYEVNDA; -.
DR   UniPathway; UPA00258; UER00370.
DR   Proteomes; UP000000558; Chromosome.
DR   Proteomes; UP000002519; Chromosome.
DR   GO; GO:0035550; C:urease complex; IEA:InterPro.
DR   GO; GO:0009039; F:urease activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0043419; P:urea catabolic process; IEA:UniProtKB-UniPathway.
DR   CDD; cd00407; Urease_beta; 1.
DR   Gene3D; 2.10.150.10; -; 1.
DR   HAMAP; MF_01954; Urease_beta; 1.
DR   InterPro; IPR002019; Urease_beta.
DR   InterPro; IPR036461; Urease_betasu_sf.
DR   Pfam; PF00699; Urease_beta; 1.
DR   SUPFAM; SSF51278; SSF51278; 1.
DR   TIGRFAMs; TIGR00192; urease_beta; 1.
PE   3: Inferred from homology;
KW   Cytoplasm; Hydrolase; Reference proteome.
FT   CHAIN           1..106
FT                   /note="Urease subunit beta"
FT                   /id="PRO_0000234248"
SQ   SEQUENCE   106 AA;  11761 MW;  8DEF15030AAA78AA CRC64;
     MIPGEYKVKP GYIELNIGRA TCSIIVENHG DRPIQVGSHY HFAEVNPALK FDRQKARGYR
     LNIAAGTAVR FEPGQKREVE LVALSGARIV HGFRGDIMGE LEANDE