URE2_UREUR
ID URE2_UREUR Reviewed; 124 AA.
AC P0CB01; P17273; Q9WVU8;
DT 28-JUL-2009, integrated into UniProtKB/Swiss-Prot.
DT 28-JUL-2009, sequence version 1.
DT 25-MAY-2022, entry version 44.
DE RecName: Full=Urease subunit beta {ECO:0000255|HAMAP-Rule:MF_01954};
DE EC=3.5.1.5 {ECO:0000255|HAMAP-Rule:MF_01954};
DE AltName: Full=Urea amidohydrolase subunit beta {ECO:0000255|HAMAP-Rule:MF_01954};
GN Name=ureB {ECO:0000255|HAMAP-Rule:MF_01954};
OS Ureaplasma urealyticum (Ureaplasma urealyticum biotype 2).
OC Bacteria; Tenericutes; Mollicutes; Mycoplasmataceae; Ureaplasma.
OX NCBI_TaxID=2130;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=ATCC 27618 / CIP 103755 / NCTC 10177 / T960 / Serovar 8;
RX PubMed=2191184; DOI=10.1111/j.1365-2958.1990.tb00636.x;
RA Blanchard A.;
RT "Ureaplasma urealyticum urease genes; use of a UGA tryptophan codon.";
RL Mol. Microbiol. 4:669-676(1990).
RN [2]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND PROTEIN SEQUENCE OF 2-36.
RC STRAIN=ATCC 27618 / CIP 103755 / NCTC 10177 / T960 / Serovar 8;
RX PubMed=2050410; DOI=10.1128/iai.59.7.2463-2469.1991;
RA Willoughby J.J., Russell W.C., Thirkell D., Burdon M.G.;
RT "Isolation and detection of urease genes in Ureaplasma urealyticum.";
RL Infect. Immun. 59:2463-2469(1991).
RN [3]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=ATCC 27618 / CIP 103755 / NCTC 10177 / T960 / Serovar 8,
RC ATCC 27814 / 23 / Serovar 2, ATCC 27816 / 58 / Serovar 4,
RC ATCC 27817 / 354 / Serovar 5, ATCC 27819 / Co / Serovar 7,
RC ATCC 33175 / Vancouver / Serovar 9, ATCC 33695 / K2 / Serovar 11,
RC ATCC 33696 / U24 / Serovar 12, and ATCC 33698 / U38 / Serovar 13;
RX PubMed=10555372; DOI=10.1099/00207713-49-4-1879;
RA Kong F., James G., Ma Z., Gordon S., Wang B., Gilbert G.L.;
RT "Phylogenetic analysis of Ureaplasma urealyticum -- support for the
RT establishment of a new species, Ureaplasma parvum.";
RL Int. J. Syst. Bacteriol. 49:1879-1889(1999).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=2 H(+) + H2O + urea = CO2 + 2 NH4(+); Xref=Rhea:RHEA:20557,
CC ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:16199,
CC ChEBI:CHEBI:16526, ChEBI:CHEBI:28938; EC=3.5.1.5;
CC Evidence={ECO:0000255|HAMAP-Rule:MF_01954};
CC -!- PATHWAY: Nitrogen metabolism; urea degradation; CO(2) and NH(3) from
CC urea (urease route): step 1/1. {ECO:0000255|HAMAP-Rule:MF_01954}.
CC -!- SUBUNIT: Heterotrimer of UreA (gamma), UreB (beta) and UreC (alpha)
CC subunits. Three heterotrimers associate to form the active enzyme.
CC {ECO:0000255|HAMAP-Rule:MF_01954}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_01954}.
CC -!- SIMILARITY: Belongs to the urease beta subunit family.
CC {ECO:0000255|HAMAP-Rule:MF_01954}.
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DR EMBL; X51315; CAA35696.1; -; Genomic_DNA.
DR EMBL; M36190; AAA79776.1; -; Genomic_DNA.
DR EMBL; AF085720; AAD28105.1; -; Genomic_DNA.
DR EMBL; AF085721; AAD28108.1; -; Genomic_DNA.
DR EMBL; AF085722; AAD28111.1; -; Genomic_DNA.
DR EMBL; AF085723; AAD28114.1; -; Genomic_DNA.
DR EMBL; AF085724; AAD28117.1; -; Genomic_DNA.
DR EMBL; AF085725; AAD28120.1; -; Genomic_DNA.
DR EMBL; AF085727; AAD28126.1; -; Genomic_DNA.
DR EMBL; AF085728; AAD28129.1; -; Genomic_DNA.
DR EMBL; AF085729; AAD28132.1; -; Genomic_DNA.
DR PIR; S10031; S10031.
DR RefSeq; WP_004025930.1; NZ_QOKT01000007.1.
DR AlphaFoldDB; P0CB01; -.
DR SMR; P0CB01; -.
DR GeneID; 45016021; -.
DR OMA; FYEVNDA; -.
DR UniPathway; UPA00258; UER00370.
DR GO; GO:0035550; C:urease complex; IEA:InterPro.
DR GO; GO:0009039; F:urease activity; IEA:UniProtKB-UniRule.
DR GO; GO:0043419; P:urea catabolic process; IEA:UniProtKB-UniPathway.
DR CDD; cd00407; Urease_beta; 1.
DR Gene3D; 2.10.150.10; -; 1.
DR HAMAP; MF_01954; Urease_beta; 1.
DR InterPro; IPR002019; Urease_beta.
DR InterPro; IPR036461; Urease_betasu_sf.
DR Pfam; PF00699; Urease_beta; 1.
DR SUPFAM; SSF51278; SSF51278; 1.
DR TIGRFAMs; TIGR00192; urease_beta; 1.
PE 1: Evidence at protein level;
KW Cytoplasm; Direct protein sequencing; Hydrolase.
FT INIT_MET 1
FT /note="Removed"
FT /evidence="ECO:0000269|PubMed:2050410"
FT CHAIN 2..124
FT /note="Urease subunit beta"
FT /id="PRO_0000067584"
FT CONFLICT 2..4
FT /note="SGS -> IICQDQ (in Ref. 1)"
FT /evidence="ECO:0000305"
FT CONFLICT 25
FT /note="I -> N (in Ref. 2; AAA79776)"
FT /evidence="ECO:0000305"
FT CONFLICT 52
FT /note="F -> L (in Ref. 2; AAA79776)"
FT /evidence="ECO:0000305"
FT CONFLICT 85..87
FT /note="PSG -> LS (in Ref. 2; AAA79776)"
FT /evidence="ECO:0000305"
FT CONFLICT 110..124
FT /note="EVWGVNGLVNGKLKK -> WSLRCKRLS (in Ref. 1 and 2)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 124 AA; 13608 MW; 00C909AE921BF23C CRC64;
MSGSSNQFTP GKLVPGAINF AEGEIVMNEG REAKVISIKN TGDRPIQVGS HFHLFETNSA
LVFFDEKGNE DKERKVAYGR RFDIPSGTAI RFEPGDKKEV SVIDLVGTRE VWGVNGLVNG
KLKK
