URE2_YERPE
ID URE2_YERPE Reviewed; 144 AA.
AC P69990; P52314; Q0WDM3; Q667P9;
DT 04-JAN-2005, integrated into UniProtKB/Swiss-Prot.
DT 04-JAN-2005, sequence version 1.
DT 25-MAY-2022, entry version 102.
DE RecName: Full=Urease subunit beta {ECO:0000255|HAMAP-Rule:MF_01954};
DE EC=3.5.1.5 {ECO:0000255|HAMAP-Rule:MF_01954};
DE AltName: Full=Urea amidohydrolase subunit beta {ECO:0000255|HAMAP-Rule:MF_01954};
GN Name=ureB {ECO:0000255|HAMAP-Rule:MF_01954}; Synonyms=yeuB;
GN OrderedLocusNames=YPO2666, y1238, YP_2467;
OS Yersinia pestis.
OC Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC Yersiniaceae; Yersinia.
OX NCBI_TaxID=632;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND LACK OF ROLE IN VIRULENCE.
RC STRAIN=6/69M;
RX PubMed=11119503; DOI=10.1128/iai.69.1.170-176.2001;
RA Sebbane F., Devalckenaere A., Foulon J., Carniel E., Simonet M.;
RT "Silencing and reactivation of urease in Yersinia pestis is determined by
RT one G residue at a specific position in the ureD gene.";
RL Infect. Immun. 69:170-176(2001).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CO-92 / Biovar Orientalis;
RX PubMed=11586360; DOI=10.1038/35097083;
RA Parkhill J., Wren B.W., Thomson N.R., Titball R.W., Holden M.T.G.,
RA Prentice M.B., Sebaihia M., James K.D., Churcher C.M., Mungall K.L.,
RA Baker S., Basham D., Bentley S.D., Brooks K., Cerdeno-Tarraga A.-M.,
RA Chillingworth T., Cronin A., Davies R.M., Davis P., Dougan G., Feltwell T.,
RA Hamlin N., Holroyd S., Jagels K., Karlyshev A.V., Leather S., Moule S.,
RA Oyston P.C.F., Quail M.A., Rutherford K.M., Simmonds M., Skelton J.,
RA Stevens K., Whitehead S., Barrell B.G.;
RT "Genome sequence of Yersinia pestis, the causative agent of plague.";
RL Nature 413:523-527(2001).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=KIM10+ / Biovar Mediaevalis;
RX PubMed=12142430; DOI=10.1128/jb.184.16.4601-4611.2002;
RA Deng W., Burland V., Plunkett G. III, Boutin A., Mayhew G.F., Liss P.,
RA Perna N.T., Rose D.J., Mau B., Zhou S., Schwartz D.C., Fetherston J.D.,
RA Lindler L.E., Brubaker R.R., Plano G.V., Straley S.C., McDonough K.A.,
RA Nilles M.L., Matson J.S., Blattner F.R., Perry R.D.;
RT "Genome sequence of Yersinia pestis KIM.";
RL J. Bacteriol. 184:4601-4611(2002).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=91001 / Biovar Mediaevalis;
RX PubMed=15368893; DOI=10.1093/dnares/11.3.179;
RA Song Y., Tong Z., Wang J., Wang L., Guo Z., Han Y., Zhang J., Pei D.,
RA Zhou D., Qin H., Pang X., Han Y., Zhai J., Li M., Cui B., Qi Z., Jin L.,
RA Dai R., Chen F., Li S., Ye C., Du Z., Lin W., Wang J., Yu J., Yang H.,
RA Wang J., Huang P., Yang R.;
RT "Complete genome sequence of Yersinia pestis strain 91001, an isolate
RT avirulent to humans.";
RL DNA Res. 11:179-197(2004).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=2 H(+) + H2O + urea = CO2 + 2 NH4(+); Xref=Rhea:RHEA:20557,
CC ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:16199,
CC ChEBI:CHEBI:16526, ChEBI:CHEBI:28938; EC=3.5.1.5;
CC Evidence={ECO:0000255|HAMAP-Rule:MF_01954};
CC -!- PATHWAY: Nitrogen metabolism; urea degradation; CO(2) and NH(3) from
CC urea (urease route): step 1/1. {ECO:0000255|HAMAP-Rule:MF_01954}.
CC -!- SUBUNIT: Heterotrimer of UreA (gamma), UreB (beta) and UreC (alpha)
CC subunits. Three heterotrimers associate to form the active enzyme.
CC {ECO:0000255|HAMAP-Rule:MF_01954}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_01954}.
CC -!- SIMILARITY: Belongs to the urease beta subunit family.
CC {ECO:0000255|HAMAP-Rule:MF_01954}.
CC -!- CAUTION: The last gene of this probable operon, ureD, gives rise to a
CC truncated protein. Absence of ureD prevents expression of active
CC urease. Correction of the mutation does not effect virulence in mice in
CC any detectable fashion, suggesting urease is not important in the
CC virulence of Y.pestis (PubMed:11119503). {ECO:0000305|PubMed:11119503}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAM84813.1; Type=Erroneous initiation; Evidence={ECO:0000305};
CC Sequence=AAS62667.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR EMBL; AF095636; AAC78633.1; -; Genomic_DNA.
DR EMBL; AL590842; CAL21285.1; -; Genomic_DNA.
DR EMBL; AE009952; AAM84813.1; ALT_INIT; Genomic_DNA.
DR EMBL; AE017042; AAS62667.1; ALT_INIT; Genomic_DNA.
DR PIR; AB0325; AB0325.
DR RefSeq; YP_002347615.1; NC_003143.1.
DR AlphaFoldDB; P69990; -.
DR SMR; P69990; -.
DR STRING; 214092.YPO2666; -.
DR PaxDb; P69990; -.
DR DNASU; 1146185; -.
DR EnsemblBacteria; AAM84813; AAM84813; y1238.
DR EnsemblBacteria; AAS62667; AAS62667; YP_2467.
DR KEGG; ype:YPO2666; -.
DR KEGG; ypj:CH55_1505; -.
DR KEGG; ypk:y1238; -.
DR KEGG; ypl:CH46_2443; -.
DR KEGG; ypm:YP_2467; -.
DR KEGG; ypv:BZ15_867; -.
DR KEGG; ypw:CH59_3546; -.
DR PATRIC; fig|214092.21.peg.3100; -.
DR eggNOG; COG0832; Bacteria.
DR HOGENOM; CLU_129707_2_0_6; -.
DR UniPathway; UPA00258; UER00370.
DR Proteomes; UP000000815; Chromosome.
DR Proteomes; UP000001019; Chromosome.
DR Proteomes; UP000002490; Chromosome.
DR GO; GO:0035550; C:urease complex; IEA:InterPro.
DR GO; GO:0009039; F:urease activity; IEA:UniProtKB-UniRule.
DR GO; GO:0043419; P:urea catabolic process; IEA:UniProtKB-UniPathway.
DR CDD; cd00407; Urease_beta; 1.
DR Gene3D; 2.10.150.10; -; 1.
DR HAMAP; MF_01954; Urease_beta; 1.
DR InterPro; IPR002019; Urease_beta.
DR InterPro; IPR036461; Urease_betasu_sf.
DR Pfam; PF00699; Urease_beta; 1.
DR SUPFAM; SSF51278; SSF51278; 1.
DR TIGRFAMs; TIGR00192; urease_beta; 1.
PE 3: Inferred from homology;
KW Cytoplasm; Hydrolase; Reference proteome.
FT CHAIN 1..144
FT /note="Urease subunit beta"
FT /id="PRO_0000067599"
SQ SEQUENCE 144 AA; 15822 MW; 0A93E654371BAEDF CRC64;
MSAKKSTKDS KEQNTPLGGL VLAETPITFN ENKPVTKVKV RNTGDRPIQV GSHFHFFEVN
RALEFDRAAA YGKRLNISST TAIRFEPGDE TEVPLIPFGG KQTLYGFNNL VDGWTGEGVV
PNSERPDKLA AIRLAAERGF KSSK
