ID   URE3_ACTNA              Reviewed;         104 AA.
AC   Q9Z395;
DT   28-NOV-2003, integrated into UniProtKB/Swiss-Prot.
DT   01-MAY-1999, sequence version 1.
DT   25-MAY-2022, entry version 89.
DE   RecName: Full=Urease subunit gamma {ECO:0000255|HAMAP-Rule:MF_00739};
DE            EC=3.5.1.5 {ECO:0000255|HAMAP-Rule:MF_00739};
DE   AltName: Full=Urea amidohydrolase subunit gamma {ECO:0000255|HAMAP-Rule:MF_00739};
GN   Name=ureA {ECO:0000255|HAMAP-Rule:MF_00739};
OS   Actinomyces naeslundii.
OC   Bacteria; Actinobacteria; Actinomycetales; Actinomycetaceae; Actinomyces.
OX   NCBI_TaxID=1655;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=WVU45;
RX   PubMed=9916052; DOI=10.1128/iai.67.2.504-512.1999;
RA   Morou-Bermudez E., Burne R.A.;
RT   "Genetic and physiologic characterization of urease of Actinomyces
RT   naeslundii.";
RL   Infect. Immun. 67:504-512(1999).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=2 H(+) + H2O + urea = CO2 + 2 NH4(+); Xref=Rhea:RHEA:20557,
CC         ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:16199,
CC         ChEBI:CHEBI:16526, ChEBI:CHEBI:28938; EC=3.5.1.5;
CC         Evidence={ECO:0000255|HAMAP-Rule:MF_00739};
CC   -!- PATHWAY: Nitrogen metabolism; urea degradation; CO(2) and NH(3) from
CC       urea (urease route): step 1/1. {ECO:0000255|HAMAP-Rule:MF_00739}.
CC   -!- SUBUNIT: Heterotrimer of UreA (gamma), UreB (beta) and UreC (alpha)
CC       subunits. Three heterotrimers associate to form the active enzyme.
CC       {ECO:0000255|HAMAP-Rule:MF_00739}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_00739}.
CC   -!- SIMILARITY: Belongs to the urease gamma subunit family.
CC       {ECO:0000255|HAMAP-Rule:MF_00739}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; AF056321; AAD13730.1; -; Genomic_DNA.
DR   EMBL; AF048778; AAD13723.1; -; Genomic_DNA.
DR   RefSeq; WP_003782040.1; NZ_PKKP01000002.1.
DR   AlphaFoldDB; Q9Z395; -.
DR   SMR; Q9Z395; -.
DR   STRING; 1655.BKH10_09500; -.
DR   GeneID; 64257294; -.
DR   GeneID; 66233904; -.
DR   BRENDA; 3.5.1.5; 134.
DR   UniPathway; UPA00258; UER00370.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0016151; F:nickel cation binding; IEA:InterPro.
DR   GO; GO:0009039; F:urease activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0043419; P:urea catabolic process; IEA:UniProtKB-UniPathway.
DR   CDD; cd00390; Urease_gamma; 1.
DR   Gene3D; 3.30.280.10; -; 1.
DR   HAMAP; MF_00739; Urease_gamma; 1.
DR   InterPro; IPR012010; Urease_gamma.
DR   InterPro; IPR002026; Urease_gamma/gamma-beta_su.
DR   InterPro; IPR036463; Urease_gamma_sf.
DR   Pfam; PF00547; Urease_gamma; 1.
DR   PIRSF; PIRSF001223; Urease_gamma; 1.
DR   SUPFAM; SSF54111; SSF54111; 1.
DR   TIGRFAMs; TIGR00193; urease_gam; 1.
PE   3: Inferred from homology;
KW   Cytoplasm; Hydrolase.
FT   CHAIN           1..104
FT                   /note="Urease subunit gamma"
FT                   /id="PRO_0000097984"
SQ   SEQUENCE   104 AA;  11736 MW;  8C103A5C8891C558 CRC64;
     MHLTPREQEK LLIVVAADLA RRRKDRGIRL NHPEAVAYIT AEILEGAREG RTVTDLMAYG
     TTLLTYDDVM EGVPEMIRAV QVEATFPDGT KLVSVHDPIR RRLP