ID   CACL1_RAT               Reviewed;         347 AA.
AC   Q5XI53;
DT   07-JUN-2005, integrated into UniProtKB/Swiss-Prot.
DT   23-NOV-2004, sequence version 1.
DT   03-AUG-2022, entry version 92.
DE   RecName: Full=CDK2-associated and cullin domain-containing protein 1;
GN   Name=Cacul1;
OS   Rattus norvegicus (Rat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Rattus.
OX   NCBI_TaxID=10116;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Testis;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
CC   -!- FUNCTION: Cell cycle associated protein capable of promoting cell
CC       proliferation through the activation of CDK2 at the G1/S phase
CC       transition. {ECO:0000250}.
CC   -!- SUBUNIT: Interacts with CDK2. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the cullin family. {ECO:0000305}.
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DR   EMBL; BC083839; AAH83839.1; -; mRNA.
DR   RefSeq; NP_001014270.1; NM_001014248.1.
DR   AlphaFoldDB; Q5XI53; -.
DR   SMR; Q5XI53; -.
DR   STRING; 10116.ENSRNOP00000051311; -.
DR   PaxDb; Q5XI53; -.
DR   Ensembl; ENSRNOT00000050617; ENSRNOP00000051311; ENSRNOG00000009954.
DR   GeneID; 365493; -.
DR   KEGG; rno:365493; -.
DR   CTD; 143384; -.
DR   RGD; 1308127; Cacul1.
DR   eggNOG; KOG2166; Eukaryota.
DR   GeneTree; ENSGT00390000000403; -.
DR   InParanoid; Q5XI53; -.
DR   PhylomeDB; Q5XI53; -.
DR   PRO; PR:Q5XI53; -.
DR   Proteomes; UP000002494; Chromosome 1.
DR   Bgee; ENSRNOG00000009954; Expressed in testis and 19 other tissues.
DR   ExpressionAtlas; Q5XI53; baseline and differential.
DR   Genevisible; Q5XI53; RN.
DR   GO; GO:0019901; F:protein kinase binding; ISO:RGD.
DR   GO; GO:0031625; F:ubiquitin protein ligase binding; IEA:InterPro.
DR   GO; GO:0000082; P:G1/S transition of mitotic cell cycle; ISS:UniProtKB.
DR   GO; GO:0008284; P:positive regulation of cell population proliferation; ISS:UniProtKB.
DR   GO; GO:0045860; P:positive regulation of protein kinase activity; ISS:UniProtKB.
DR   GO; GO:0006511; P:ubiquitin-dependent protein catabolic process; IEA:InterPro.
DR   InterPro; IPR042652; CACUL1.
DR   InterPro; IPR001373; Cullin_N.
DR   InterPro; IPR016159; Cullin_repeat-like_dom_sf.
DR   PANTHER; PTHR46636; PTHR46636; 2.
DR   Pfam; PF00888; Cullin; 1.
DR   SUPFAM; SSF74788; SSF74788; 1.
PE   2: Evidence at transcript level;
KW   Cell cycle; Reference proteome.
FT   CHAIN           1..347
FT                   /note="CDK2-associated and cullin domain-containing protein
FT                   1"
FT                   /id="PRO_0000119819"
FT   REGION          1..63
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          320..347
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        33..54
FT                   /note="Pro residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   347 AA;  38826 MW;  E6CFF9964A5F63CA CRC64;
     MEESMEEEEM LTYEAMMDDQ NHNNWEAAVD SFRQPPPAPP LPPPPPPRPS SSIPDPGREL
     PGGQLLAVHA GSMDRKGLKE GLPMGSPPLS EPNGVIMMLK SCDAAAAVAK AAPAPTPSST
     ININTSTSKF LMNVITIEDY KSTYWPKLDG AIDQLLTQSP GDYIPISYEQ IYSCVYKCVC
     QQHSEQMYSD LIKKITSHLE RVSKELQASP PDLYIERFNI ALGQYMGALQ SIVPLFIYMN
     KFYIETKLNR DLKDDLIKLF TEHVAEKHIY SLMQWVQMAP TLFSKFIPNI LPPAVESELS
     EYAAQDQKLQ RELIQNGFTR GDQSRKRAGD ELAYNSPSAC ASSRGYR