CACLC_ARATH
ID CACLC_ARATH Reviewed; 665 AA.
AC A0MFS9; Q5XVG1; Q9SSM5;
DT 25-JAN-2012, integrated into UniProtKB/Swiss-Prot.
DT 12-DEC-2006, sequence version 1.
DT 03-AUG-2022, entry version 92.
DE RecName: Full=Anoctamin-like protein At1g73020;
GN OrderedLocusNames=At1g73020; ORFNames=F3N23.22;
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=11130712; DOI=10.1038/35048500;
RA Theologis A., Ecker J.R., Palm C.J., Federspiel N.A., Kaul S., White O.,
RA Alonso J., Altafi H., Araujo R., Bowman C.L., Brooks S.Y., Buehler E.,
RA Chan A., Chao Q., Chen H., Cheuk R.F., Chin C.W., Chung M.K., Conn L.,
RA Conway A.B., Conway A.R., Creasy T.H., Dewar K., Dunn P., Etgu P.,
RA Feldblyum T.V., Feng J.-D., Fong B., Fujii C.Y., Gill J.E., Goldsmith A.D.,
RA Haas B., Hansen N.F., Hughes B., Huizar L., Hunter J.L., Jenkins J.,
RA Johnson-Hopson C., Khan S., Khaykin E., Kim C.J., Koo H.L.,
RA Kremenetskaia I., Kurtz D.B., Kwan A., Lam B., Langin-Hooper S., Lee A.,
RA Lee J.M., Lenz C.A., Li J.H., Li Y.-P., Lin X., Liu S.X., Liu Z.A.,
RA Luros J.S., Maiti R., Marziali A., Militscher J., Miranda M., Nguyen M.,
RA Nierman W.C., Osborne B.I., Pai G., Peterson J., Pham P.K., Rizzo M.,
RA Rooney T., Rowley D., Sakano H., Salzberg S.L., Schwartz J.R., Shinn P.,
RA Southwick A.M., Sun H., Tallon L.J., Tambunga G., Toriumi M.J., Town C.D.,
RA Utterback T., Van Aken S., Vaysberg M., Vysotskaia V.S., Walker M., Wu D.,
RA Yu G., Fraser C.M., Venter J.C., Davis R.W.;
RT "Sequence and analysis of chromosome 1 of the plant Arabidopsis thaliana.";
RL Nature 408:816-820(2000).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=cv. Columbia;
RA Xiao Y.-L., Underwood B.A., Moskal W.A. Jr., Wang W., Redman J.C., Wu H.C.,
RA Utterback T., Town C.D.;
RT "Reconstruction of cDNA sequences for hypothetical genes in Arabidopsis
RT thaliana from 5' and 3' RACE products.";
RL Submitted (AUG-2004) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=cv. Columbia;
RX PubMed=17147637; DOI=10.1111/j.1467-7652.2006.00183.x;
RA Underwood B.A., Vanderhaeghen R., Whitford R., Town C.D., Hilson P.;
RT "Simultaneous high-throughput recombinational cloning of open reading
RT frames in closed and open configurations.";
RL Plant Biotechnol. J. 4:317-324(2006).
RN [5]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=19376835; DOI=10.1104/pp.109.138677;
RA Reiland S., Messerli G., Baerenfaller K., Gerrits B., Endler A.,
RA Grossmann J., Gruissem W., Baginsky S.;
RT "Large-scale Arabidopsis phosphoproteome profiling reveals novel
RT chloroplast kinase substrates and phosphorylation networks.";
RL Plant Physiol. 150:889-903(2009).
CC -!- FUNCTION: May act as a calcium-activated chloride channel.
CC {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC protein {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the anoctamin (TC 1.A.17) family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAD55649.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
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DR EMBL; AC008017; AAD55649.1; ALT_SEQ; Genomic_DNA.
DR EMBL; CP002684; AEE35404.1; -; Genomic_DNA.
DR EMBL; CP002684; AEE35405.1; -; Genomic_DNA.
DR EMBL; CP002684; ANM58018.1; -; Genomic_DNA.
DR EMBL; AY735561; AAU44431.1; -; mRNA.
DR EMBL; DQ653406; ABK28785.1; -; mRNA.
DR PIR; F96755; F96755.
DR RefSeq; NP_001185388.1; NM_001198459.1.
DR RefSeq; NP_001320486.1; NM_001334561.1.
DR RefSeq; NP_177445.2; NM_105960.5.
DR AlphaFoldDB; A0MFS9; -.
DR SMR; A0MFS9; -.
DR STRING; 3702.AT1G73020.1; -.
DR TCDB; 1.A.17.1.11; the calcium-dependent chloride channel (ca-clc) family.
DR iPTMnet; A0MFS9; -.
DR PaxDb; A0MFS9; -.
DR PRIDE; A0MFS9; -.
DR ProteomicsDB; 239089; -.
DR EnsemblPlants; AT1G73020.1; AT1G73020.1; AT1G73020.
DR EnsemblPlants; AT1G73020.2; AT1G73020.2; AT1G73020.
DR EnsemblPlants; AT1G73020.3; AT1G73020.3; AT1G73020.
DR GeneID; 843633; -.
DR Gramene; AT1G73020.1; AT1G73020.1; AT1G73020.
DR Gramene; AT1G73020.2; AT1G73020.2; AT1G73020.
DR Gramene; AT1G73020.3; AT1G73020.3; AT1G73020.
DR KEGG; ath:AT1G73020; -.
DR Araport; AT1G73020; -.
DR TAIR; locus:2032763; AT1G73020.
DR eggNOG; KOG2513; Eukaryota.
DR HOGENOM; CLU_027680_0_0_1; -.
DR InParanoid; A0MFS9; -.
DR OMA; NLGVDWV; -.
DR OrthoDB; 1263362at2759; -.
DR PhylomeDB; A0MFS9; -.
DR PRO; PR:A0MFS9; -.
DR Proteomes; UP000006548; Chromosome 1.
DR ExpressionAtlas; A0MFS9; baseline and differential.
DR Genevisible; A0MFS9; AT.
DR GO; GO:0034707; C:chloride channel complex; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR GO; GO:0005254; F:chloride channel activity; IBA:GO_Central.
DR GO; GO:1902476; P:chloride transmembrane transport; IBA:GO_Central.
DR GO; GO:0055085; P:transmembrane transport; IBA:GO_Central.
DR InterPro; IPR007632; Anoctamin.
DR PANTHER; PTHR12308; PTHR12308; 1.
DR Pfam; PF04547; Anoctamin; 1.
PE 1: Evidence at protein level;
KW Calcium; Chloride; Chloride channel; Ion channel; Ion transport; Membrane;
KW Reference proteome; Transmembrane; Transmembrane helix; Transport.
FT CHAIN 1..665
FT /note="Anoctamin-like protein At1g73020"
FT /id="PRO_0000415285"
FT TRANSMEM 200..220
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 230..250
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 322..342
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 344..364
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 392..412
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 508..528
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 551..571
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 591..611
FT /note="Helical"
FT /evidence="ECO:0000255"
FT CONFLICT 243
FT /note="W -> R (in Ref. 3; AAU44431)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 665 AA; 76805 MW; 74A337290D492D39 CRC64;
MNGSNGEERV VHEVAMVVPK RVLEEEEGDC VEVLVTELRK KGMVVDRVVG LAHEFLKVAA
PSEILGNAAA ELHIRKPTRL GIDLPFEMQG SEAFIRQPDG LLFSWFERFR CYQHLIYGIV
NSGGHDVTLK LDGREFCWTA GESLLRRLES EGVIKQMFPL HDELKRKELL QNWALNWWNC
TNQPIDQIYS YFGAKIGVYF SFLGMYTQWL IFPALLGFIV QMVDFGSLQF LALPSFFVGT
ILWAALFLQF WKRKNAALLA RWQINCLVGP SQGYRFLGME WSSLPFPKEL IKNLGNERAK
EKEAYQRYEW FAYRKRFRND VLVIMSIICL QLPFELAYAH IFEIITSDII KYVLTAIYLL
IIQYLTRLGG KVSVKLINRE INESVEYRAN SLIYKVFGLY FMQTYIGIFY HVLLHRNFMT
LRQVLIQRLI ISQVFWTLMD GSLPYLKYSY RKYRARTKKK MEDGSSTGKI QIASRVEKEY
FKPTYSASIG VELEDGLFDD SLELALQFGM IMMFACAFPL AFALAAVSNV MEIRTNALKL
LVTLRRPLPR AAATIGAWLN IWQFLVVMSI CTNSALLVCL YDQEGKWKIE PGLAAILIME
HVLLLLKFGL SRLVPEEPAW VRASRVKNVT QAQDMYCKQL LRSISGEFNS LTKPEQEQQQ
DSERF
