ID   CACO1_DANRE             Reviewed;         640 AA.
AC   A2BGD5;
DT   23-OCT-2007, integrated into UniProtKB/Swiss-Prot.
DT   20-FEB-2007, sequence version 1.
DT   03-AUG-2022, entry version 68.
DE   RecName: Full=Calcium-binding and coiled-coil domain-containing protein 1;
GN   Name=calcoco1; ORFNames=si:dkey-148f24.4;
OS   Danio rerio (Zebrafish) (Brachydanio rerio).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC   Danionidae; Danioninae; Danio.
OX   NCBI_TaxID=7955;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Tuebingen;
RX   PubMed=23594743; DOI=10.1038/nature12111;
RA   Howe K., Clark M.D., Torroja C.F., Torrance J., Berthelot C., Muffato M.,
RA   Collins J.E., Humphray S., McLaren K., Matthews L., McLaren S., Sealy I.,
RA   Caccamo M., Churcher C., Scott C., Barrett J.C., Koch R., Rauch G.J.,
RA   White S., Chow W., Kilian B., Quintais L.T., Guerra-Assuncao J.A., Zhou Y.,
RA   Gu Y., Yen J., Vogel J.H., Eyre T., Redmond S., Banerjee R., Chi J., Fu B.,
RA   Langley E., Maguire S.F., Laird G.K., Lloyd D., Kenyon E., Donaldson S.,
RA   Sehra H., Almeida-King J., Loveland J., Trevanion S., Jones M., Quail M.,
RA   Willey D., Hunt A., Burton J., Sims S., McLay K., Plumb B., Davis J.,
RA   Clee C., Oliver K., Clark R., Riddle C., Elliot D., Threadgold G.,
RA   Harden G., Ware D., Begum S., Mortimore B., Kerry G., Heath P.,
RA   Phillimore B., Tracey A., Corby N., Dunn M., Johnson C., Wood J., Clark S.,
RA   Pelan S., Griffiths G., Smith M., Glithero R., Howden P., Barker N.,
RA   Lloyd C., Stevens C., Harley J., Holt K., Panagiotidis G., Lovell J.,
RA   Beasley H., Henderson C., Gordon D., Auger K., Wright D., Collins J.,
RA   Raisen C., Dyer L., Leung K., Robertson L., Ambridge K., Leongamornlert D.,
RA   McGuire S., Gilderthorp R., Griffiths C., Manthravadi D., Nichol S.,
RA   Barker G., Whitehead S., Kay M., Brown J., Murnane C., Gray E.,
RA   Humphries M., Sycamore N., Barker D., Saunders D., Wallis J., Babbage A.,
RA   Hammond S., Mashreghi-Mohammadi M., Barr L., Martin S., Wray P.,
RA   Ellington A., Matthews N., Ellwood M., Woodmansey R., Clark G., Cooper J.,
RA   Tromans A., Grafham D., Skuce C., Pandian R., Andrews R., Harrison E.,
RA   Kimberley A., Garnett J., Fosker N., Hall R., Garner P., Kelly D., Bird C.,
RA   Palmer S., Gehring I., Berger A., Dooley C.M., Ersan-Urun Z., Eser C.,
RA   Geiger H., Geisler M., Karotki L., Kirn A., Konantz J., Konantz M.,
RA   Oberlander M., Rudolph-Geiger S., Teucke M., Lanz C., Raddatz G.,
RA   Osoegawa K., Zhu B., Rapp A., Widaa S., Langford C., Yang F.,
RA   Schuster S.C., Carter N.P., Harrow J., Ning Z., Herrero J., Searle S.M.,
RA   Enright A., Geisler R., Plasterk R.H., Lee C., Westerfield M.,
RA   de Jong P.J., Zon L.I., Postlethwait J.H., Nusslein-Volhard C.,
RA   Hubbard T.J., Roest Crollius H., Rogers J., Stemple D.L.;
RT   "The zebrafish reference genome sequence and its relationship to the human
RT   genome.";
RL   Nature 496:498-503(2013).
CC   -!- FUNCTION: May function as a coactivator for aryl hydrocarbon and
CC       nuclear receptors. {ECO:0000250|UniProtKB:Q8CGU1}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q9DEX1}. Nucleus
CC       {ECO:0000250|UniProtKB:Q9DEX1}. Note=Shuttles between nucleus and
CC       cytoplasm. {ECO:0000250|UniProtKB:Q9DEX1}.
CC   -!- SIMILARITY: Belongs to the CALCOCO family. {ECO:0000305}.
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DR   EMBL; BX465864; CAM14487.1; -; Genomic_DNA.
DR   RefSeq; NP_001103636.1; NM_001110166.1.
DR   AlphaFoldDB; A2BGD5; -.
DR   SMR; A2BGD5; -.
DR   STRING; 7955.ENSDARP00000093924; -.
DR   PaxDb; A2BGD5; -.
DR   Ensembl; ENSDART00000103150; ENSDARP00000093924; ENSDARG00000036695.
DR   GeneID; 334971; -.
DR   KEGG; dre:334971; -.
DR   CTD; 334971; -.
DR   ZFIN; ZDB-GENE-030131-6911; calcoco1a.
DR   eggNOG; ENOG502QR9J; Eukaryota.
DR   GeneTree; ENSGT00950000183025; -.
DR   InParanoid; A2BGD5; -.
DR   PhylomeDB; A2BGD5; -.
DR   TreeFam; TF329501; -.
DR   Reactome; R-DRE-5357905; Regulation of TNFR1 signaling.
DR   Reactome; R-DRE-936440; Negative regulators of DDX58/IFIH1 signaling.
DR   PRO; PR:A2BGD5; -.
DR   Proteomes; UP000000437; Genome assembly.
DR   Proteomes; UP000814640; Chromosome 23.
DR   Bgee; ENSDARG00000036695; Expressed in muscle tissue and 23 other tissues.
DR   ExpressionAtlas; A2BGD5; baseline.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0003713; F:transcription coactivator activity; IBA:GO_Central.
DR   GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR   InterPro; IPR012852; CALCOCO1-like.
DR   InterPro; IPR041611; SKICH.
DR   Pfam; PF07888; CALCOCO1; 1.
DR   Pfam; PF17751; SKICH; 1.
PE   3: Inferred from homology;
KW   Coiled coil; Cytoplasm; Nucleus; Reference proteome.
FT   CHAIN           1..640
FT                   /note="Calcium-binding and coiled-coil domain-containing
FT                   protein 1"
FT                   /id="PRO_0000308903"
FT   REGION          262..288
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          519..640
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          141..212
FT                   /evidence="ECO:0000255"
FT   COILED          246..346
FT                   /evidence="ECO:0000255"
FT   COILED          424..510
FT                   /evidence="ECO:0000255"
FT   COMPBIAS        539..555
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        575..594
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   640 AA;  73425 MW;  E2DCCF96472B0BC6 CRC64;
     MEKTWRVEFR NVGSCYFPQS RVDCHYTINP QHTWASNDWI GLFKVGWSSV KEYHTFVWAV
     APSSYKEGTS VNCCVNFQAS YLPGPSAQQY QFVYVDGKGE ICSCSAAFTF SAPKPLEELV
     TLEEEGQGEE VGEDMLLVIP RAQLLQSRLQ ECLKERAELL QALEAADQNV EREKGRRERD
     RGSWEHTRKE LERKIDDLKE EVREYREKVE DMKKKQKEVE DLGEALTEEK RALLAQKEAN
     EQRIRELEED IKILTQRGLE RETDLERMRE RAKKSAAQKR EDEDEHKNLK LKMEQTEKEL
     HSLSAEFQSL RSSLAQRDTH ALQLRDTITT LTHKLNSAHR KEAANELALN ELRSVQERLN
     VSEHCVETLR GELRDMVAQR DSAHAELHQA RLQAAQLTLQ LADASLALRE GRANWAQERE
     TLQQNAEIDK VRLERQNDEI QQKEEMLQKA RMEREKAVVE LGREKDCNRE LKASLRVAQK
     EKEQLQTEIQ EVMEYSRQLE RRLEVLSDCK WSETALLQSS RAESPLLSDS EDENPEALQD
     THSSGPLNHY SLCEQPQSDL LLPATPPPSP RHPSTVVISQ PAPLSSPHQP SARSHTHSSE
     SEEEYEAALS GGHSSGEETA LLLPDNRDTT LGELAESPLW