ID   URE3_HALMA              Reviewed;         128 AA.
AC   Q75ZQ4; Q5V6L6;
DT   02-MAY-2006, integrated into UniProtKB/Swiss-Prot.
DT   05-JUL-2004, sequence version 1.
DT   25-MAY-2022, entry version 105.
DE   RecName: Full=Urease subunit gamma {ECO:0000255|HAMAP-Rule:MF_00739};
DE            EC=3.5.1.5 {ECO:0000255|HAMAP-Rule:MF_00739};
DE   AltName: Full=Urea amidohydrolase subunit gamma {ECO:0000255|HAMAP-Rule:MF_00739};
GN   Name=ureA {ECO:0000255|HAMAP-Rule:MF_00739}; OrderedLocusNames=pNG7125;
OS   Haloarcula marismortui (strain ATCC 43049 / DSM 3752 / JCM 8966 / VKM
OS   B-1809) (Halobacterium marismortui).
OG   Plasmid pNG700.
OC   Archaea; Euryarchaeota; Stenosarchaea group; Halobacteria; Halobacteriales;
OC   Haloarculaceae; Haloarcula.
OX   NCBI_TaxID=272569;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=ATCC 43049 / DSM 3752 / JCM 8966 / VKM B-1809;
RX   PubMed=14981304; DOI=10.1271/bbb.68.397;
RA   Mizuki T., Kamekura M., DasSarma S., Fukushima T., Usami R., Yoshida Y.,
RA   Horikoshi K.;
RT   "Ureases of extreme halophiles of the genus Haloarcula with a unique
RT   structure of gene cluster.";
RL   Biosci. Biotechnol. Biochem. 68:397-406(2004).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 43049 / DSM 3752 / JCM 8966 / VKM B-1809; PLASMID=pNG700;
RX   PubMed=15520287; DOI=10.1101/gr.2700304;
RA   Baliga N.S., Bonneau R., Facciotti M.T., Pan M., Glusman G., Deutsch E.W.,
RA   Shannon P., Chiu Y., Weng R.S., Gan R.R., Hung P., Date S.V., Marcotte E.,
RA   Hood L., Ng W.V.;
RT   "Genome sequence of Haloarcula marismortui: a halophilic archaeon from the
RT   Dead Sea.";
RL   Genome Res. 14:2221-2234(2004).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=2 H(+) + H2O + urea = CO2 + 2 NH4(+); Xref=Rhea:RHEA:20557,
CC         ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:16199,
CC         ChEBI:CHEBI:16526, ChEBI:CHEBI:28938; EC=3.5.1.5;
CC         Evidence={ECO:0000255|HAMAP-Rule:MF_00739};
CC   -!- PATHWAY: Nitrogen metabolism; urea degradation; CO(2) and NH(3) from
CC       urea (urease route): step 1/1. {ECO:0000255|HAMAP-Rule:MF_00739}.
CC   -!- SUBUNIT: Heterotrimer of UreA (gamma), UreB (beta) and UreC (alpha)
CC       subunits. Three heterotrimers associate to form the active enzyme.
CC       {ECO:0000255|HAMAP-Rule:MF_00739}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_00739}.
CC   -!- SIMILARITY: Belongs to the urease gamma subunit family.
CC       {ECO:0000255|HAMAP-Rule:MF_00739}.
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DR   EMBL; AB119092; BAC84959.1; -; Genomic_DNA.
DR   EMBL; AY596296; AAV44836.1; -; Genomic_DNA.
DR   RefSeq; WP_004965718.1; NZ_CP039137.1.
DR   AlphaFoldDB; Q75ZQ4; -.
DR   SMR; Q75ZQ4; -.
DR   EnsemblBacteria; AAV44836; AAV44836; pNG7125.
DR   GeneID; 40151397; -.
DR   GeneID; 64825409; -.
DR   KEGG; hma:pNG7125; -.
DR   PATRIC; fig|272569.17.peg.568; -.
DR   HOGENOM; CLU_145825_0_0_2; -.
DR   OMA; MQLTPHE; -.
DR   BRENDA; 3.5.1.5; 2549.
DR   UniPathway; UPA00258; UER00370.
DR   Proteomes; UP000001169; Plasmid pNG700.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0016151; F:nickel cation binding; IEA:InterPro.
DR   GO; GO:0009039; F:urease activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0043419; P:urea catabolic process; IEA:UniProtKB-UniPathway.
DR   CDD; cd00390; Urease_gamma; 1.
DR   Gene3D; 3.30.280.10; -; 1.
DR   HAMAP; MF_00739; Urease_gamma; 1.
DR   InterPro; IPR012010; Urease_gamma.
DR   InterPro; IPR002026; Urease_gamma/gamma-beta_su.
DR   InterPro; IPR036463; Urease_gamma_sf.
DR   Pfam; PF00547; Urease_gamma; 1.
DR   SUPFAM; SSF54111; SSF54111; 1.
DR   TIGRFAMs; TIGR00193; urease_gam; 1.
PE   3: Inferred from homology;
KW   Cytoplasm; Hydrolase; Plasmid; Reference proteome.
FT   CHAIN           1..128
FT                   /note="Urease subunit gamma"
FT                   /id="PRO_0000234220"
FT   REGION          97..128
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   128 AA;  13873 MW;  14BB3BBECF2925C2 CRC64;
     MKLTAKEQER LTVFTAAEVA RRRKERGVPL NHPEAVAYIS DWCIERGRDG QSVAEIRSGA
     SKLLGREDVM DGVPEMIDMI QVEPVFPDGT KLVTVHDPIR SDSVGSADDE TTESEAATDG
     GDSAGTDE