ID   URE3_UREUR              Reviewed;         101 AA.
AC   P0CB02; P17274; Q9R2R9;
DT   28-JUL-2009, integrated into UniProtKB/Swiss-Prot.
DT   28-JUL-2009, sequence version 1.
DT   25-MAY-2022, entry version 48.
DE   RecName: Full=Urease subunit gamma {ECO:0000255|HAMAP-Rule:MF_00739};
DE            EC=3.5.1.5 {ECO:0000255|HAMAP-Rule:MF_00739};
DE   AltName: Full=Urea amidohydrolase subunit gamma {ECO:0000255|HAMAP-Rule:MF_00739};
GN   Name=ureA {ECO:0000255|HAMAP-Rule:MF_00739};
OS   Ureaplasma urealyticum (Ureaplasma urealyticum biotype 2).
OC   Bacteria; Tenericutes; Mollicutes; Mycoplasmataceae; Ureaplasma.
OX   NCBI_TaxID=2130;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=ATCC 27618 / CIP 103755 / NCTC 10177 / T960 / Serovar 8;
RX   PubMed=2191184; DOI=10.1111/j.1365-2958.1990.tb00636.x;
RA   Blanchard A.;
RT   "Ureaplasma urealyticum urease genes; use of a UGA tryptophan codon.";
RL   Mol. Microbiol. 4:669-676(1990).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=ATCC 27618 / CIP 103755 / NCTC 10177 / T960 / Serovar 8,
RC   ATCC 27814 / 23 / Serovar 2, ATCC 27816 / 58 / Serovar 4,
RC   ATCC 27817 / 354 / Serovar 5, ATCC 27819 / Co / Serovar 7,
RC   ATCC 33175 / Vancouver / Serovar 9, ATCC 33695 / K2 / Serovar 11,
RC   ATCC 33696 / U24 / Serovar 12, and ATCC 33698 / U38 / Serovar 13;
RX   PubMed=10555372; DOI=10.1099/00207713-49-4-1879;
RA   Kong F., James G., Ma Z., Gordon S., Wang B., Gilbert G.L.;
RT   "Phylogenetic analysis of Ureaplasma urealyticum -- support for the
RT   establishment of a new species, Ureaplasma parvum.";
RL   Int. J. Syst. Bacteriol. 49:1879-1889(1999).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=2 H(+) + H2O + urea = CO2 + 2 NH4(+); Xref=Rhea:RHEA:20557,
CC         ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:16199,
CC         ChEBI:CHEBI:16526, ChEBI:CHEBI:28938; EC=3.5.1.5;
CC         Evidence={ECO:0000255|HAMAP-Rule:MF_00739};
CC   -!- PATHWAY: Nitrogen metabolism; urea degradation; CO(2) and NH(3) from
CC       urea (urease route): step 1/1. {ECO:0000255|HAMAP-Rule:MF_00739}.
CC   -!- SUBUNIT: Heterotrimer of UreA (gamma), UreB (beta) and UreC (alpha)
CC       subunits. Three heterotrimers associate to form the active enzyme.
CC       {ECO:0000255|HAMAP-Rule:MF_00739}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_00739}.
CC   -!- SIMILARITY: Belongs to the urease gamma subunit family.
CC       {ECO:0000255|HAMAP-Rule:MF_00739}.
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DR   EMBL; X51315; CAA35695.1; -; Genomic_DNA.
DR   EMBL; AF085720; AAD28104.1; -; Genomic_DNA.
DR   EMBL; AF085721; AAD28107.1; -; Genomic_DNA.
DR   EMBL; AF085722; AAD28110.1; -; Genomic_DNA.
DR   EMBL; AF085723; AAD28113.1; -; Genomic_DNA.
DR   EMBL; AF085724; AAD28116.1; -; Genomic_DNA.
DR   EMBL; AF085725; AAD28119.1; -; Genomic_DNA.
DR   EMBL; AF085727; AAD28125.1; -; Genomic_DNA.
DR   EMBL; AF085728; AAD28128.1; -; Genomic_DNA.
DR   EMBL; AF085729; AAD28131.1; -; Genomic_DNA.
DR   PIR; S10030; S10030.
DR   AlphaFoldDB; P0CB02; -.
DR   SMR; P0CB02; -.
DR   UniPathway; UPA00258; UER00370.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0016151; F:nickel cation binding; IEA:InterPro.
DR   GO; GO:0009039; F:urease activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0043419; P:urea catabolic process; IEA:UniProtKB-UniPathway.
DR   CDD; cd00390; Urease_gamma; 1.
DR   Gene3D; 3.30.280.10; -; 1.
DR   HAMAP; MF_00739; Urease_gamma; 1.
DR   InterPro; IPR012010; Urease_gamma.
DR   InterPro; IPR002026; Urease_gamma/gamma-beta_su.
DR   InterPro; IPR036463; Urease_gamma_sf.
DR   Pfam; PF00547; Urease_gamma; 1.
DR   PIRSF; PIRSF001223; Urease_gamma; 1.
DR   SUPFAM; SSF54111; SSF54111; 1.
DR   TIGRFAMs; TIGR00193; urease_gam; 1.
PE   3: Inferred from homology;
KW   Cytoplasm; Hydrolase.
FT   CHAIN           1..101
FT                   /note="Urease subunit gamma"
FT                   /id="PRO_0000098057"
FT   CONFLICT        35
FT                   /note="A -> R (in Ref. 1; CAA35695)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        97
FT                   /note="S -> D (in Ref. 1; CAA35695)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   101 AA;  11129 MW;  E93D1FCD9A9C9F12 CRC64;
     MNLSLREIQK LLVTVAADVA RRRLARGLKL NYSEAVALIT DHVVEGARDG KLVADLMQSA
     REVLRVDQVM EGVDTMVGII QVEVTFPDGT KLVSVHSPIY K