ID   URE3_YEREN              Reviewed;         100 AA.
AC   P31496;
DT   01-JUL-1993, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1995, sequence version 2.
DT   25-MAY-2022, entry version 108.
DE   RecName: Full=Urease subunit gamma {ECO:0000255|HAMAP-Rule:MF_00739};
DE            EC=3.5.1.5 {ECO:0000255|HAMAP-Rule:MF_00739};
DE   AltName: Full=Urea amidohydrolase subunit gamma {ECO:0000255|HAMAP-Rule:MF_00739};
GN   Name=ureA {ECO:0000255|HAMAP-Rule:MF_00739}; Synonyms=yeuA;
OS   Yersinia enterocolitica.
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Yersiniaceae; Yersinia.
OX   NCBI_TaxID=630;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=A2635 / Serotype O:8;
RX   PubMed=8045421; DOI=10.1016/0378-1119(94)90318-2;
RA   de Koning-Ward T.F., Ward A.C., Robins-Browne R.M.;
RT   "Characterisation of the urease-encoding gene complex of Yersinia
RT   enterocolitica.";
RL   Gene 145:25-32(1994).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=6471/76 / Serotype O:3;
RX   PubMed=8500886; DOI=10.1128/iai.61.6.2498-2504.1993;
RA   Skurnik M., Batsford S., Mertz A.K.H., Schiltz E., Toivanen P.;
RT   "The putative arthritogenic cationic 19-kilodalton antigen of Yersinia
RT   enterocolitica is a urease beta-subunit.";
RL   Infect. Immun. 61:2498-2504(1993).
RN   [3]
RP   ROLE IN VIRULENCE.
RC   STRAIN=W22703 / Serogroup O:9;
RX   PubMed=7558281; DOI=10.1128/iai.63.10.3790-3795.1995;
RA   de Koning-Ward T.F., Robins-Browne R.M.;
RT   "Contribution of urease to acid tolerance in Yersinia enterocolitica.";
RL   Infect. Immun. 63:3790-3795(1995).
CC   -!- FUNCTION: Expression of the urease operon increases the likelihood of
CC       bacterial survival by contibuting to acid resistance in vitro and in
CC       vivo in BALB/c mice. Y.enterocolitica enters the body via an oral path
CC       and must survive the acidic stomach before being able to colonize the
CC       intestinal mucosa (PubMed:7558281). {ECO:0000269|PubMed:7558281}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=2 H(+) + H2O + urea = CO2 + 2 NH4(+); Xref=Rhea:RHEA:20557,
CC         ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:16199,
CC         ChEBI:CHEBI:16526, ChEBI:CHEBI:28938; EC=3.5.1.5;
CC         Evidence={ECO:0000255|HAMAP-Rule:MF_00739};
CC   -!- PATHWAY: Nitrogen metabolism; urea degradation; CO(2) and NH(3) from
CC       urea (urease route): step 1/1. {ECO:0000255|HAMAP-Rule:MF_00739}.
CC   -!- SUBUNIT: Heterotrimer of UreA (gamma), UreB (beta) and UreC (alpha)
CC       subunits. Three heterotrimers associate to form the active enzyme.
CC       {ECO:0000255|HAMAP-Rule:MF_00739}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_00739}.
CC   -!- SIMILARITY: Belongs to the urease gamma subunit family.
CC       {ECO:0000255|HAMAP-Rule:MF_00739}.
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DR   EMBL; L24101; AAA50994.1; -; Genomic_DNA.
DR   EMBL; Z18865; CAA79314.1; -; Genomic_DNA.
DR   PIR; S31417; S31417.
DR   AlphaFoldDB; P31496; -.
DR   SMR; P31496; -.
DR   UniPathway; UPA00258; UER00370.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0016151; F:nickel cation binding; IEA:InterPro.
DR   GO; GO:0009039; F:urease activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0043419; P:urea catabolic process; IEA:UniProtKB-UniPathway.
DR   CDD; cd00390; Urease_gamma; 1.
DR   Gene3D; 3.30.280.10; -; 1.
DR   HAMAP; MF_00739; Urease_gamma; 1.
DR   InterPro; IPR012010; Urease_gamma.
DR   InterPro; IPR002026; Urease_gamma/gamma-beta_su.
DR   InterPro; IPR036463; Urease_gamma_sf.
DR   Pfam; PF00547; Urease_gamma; 1.
DR   PIRSF; PIRSF001223; Urease_gamma; 1.
DR   SUPFAM; SSF54111; SSF54111; 1.
DR   TIGRFAMs; TIGR00193; urease_gam; 1.
PE   3: Inferred from homology;
KW   Cytoplasm; Hydrolase; Virulence.
FT   CHAIN           1..100
FT                   /note="Urease subunit gamma"
FT                   /id="PRO_0000098061"
FT   CONFLICT        24
FT                   /note="K -> KPK (in Ref. 2)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        41
FT                   /note="E -> V (in Ref. 2; CAA79314)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   100 AA;  11079 MW;  9590BEF9601E24E8 CRC64;
     MQLTPREVEK LMIYTLSDVA FKRKARGLKL NYPEAVSIIT ETAMEGARDG KSVEDVMKEA
     SKVLTKDDVM DGVADLIPNV QVEAIFTDGS RLVTVHDPIK