URE3_YERPE
ID URE3_YERPE Reviewed; 100 AA.
AC P69994; P52315; Q0WDM4; Q667P8; Q9ZFS0;
DT 04-JAN-2005, integrated into UniProtKB/Swiss-Prot.
DT 04-JAN-2005, sequence version 1.
DT 25-MAY-2022, entry version 108.
DE RecName: Full=Urease subunit gamma {ECO:0000255|HAMAP-Rule:MF_00739};
DE EC=3.5.1.5 {ECO:0000255|HAMAP-Rule:MF_00739};
DE AltName: Full=Urea amidohydrolase subunit gamma {ECO:0000255|HAMAP-Rule:MF_00739};
GN Name=ureA {ECO:0000255|HAMAP-Rule:MF_00739}; Synonyms=yeuA;
GN OrderedLocusNames=YPO2665, y1237, YP_2466;
OS Yersinia pestis.
OC Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC Yersiniaceae; Yersinia.
OX NCBI_TaxID=632;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND LACK OF ROLE IN VIRULENCE.
RC STRAIN=6/69M;
RX PubMed=11119503; DOI=10.1128/iai.69.1.170-176.2001;
RA Sebbane F., Devalckenaere A., Foulon J., Carniel E., Simonet M.;
RT "Silencing and reactivation of urease in Yersinia pestis is determined by
RT one G residue at a specific position in the ureD gene.";
RL Infect. Immun. 69:170-176(2001).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CO-92 / Biovar Orientalis;
RX PubMed=11586360; DOI=10.1038/35097083;
RA Parkhill J., Wren B.W., Thomson N.R., Titball R.W., Holden M.T.G.,
RA Prentice M.B., Sebaihia M., James K.D., Churcher C.M., Mungall K.L.,
RA Baker S., Basham D., Bentley S.D., Brooks K., Cerdeno-Tarraga A.-M.,
RA Chillingworth T., Cronin A., Davies R.M., Davis P., Dougan G., Feltwell T.,
RA Hamlin N., Holroyd S., Jagels K., Karlyshev A.V., Leather S., Moule S.,
RA Oyston P.C.F., Quail M.A., Rutherford K.M., Simmonds M., Skelton J.,
RA Stevens K., Whitehead S., Barrell B.G.;
RT "Genome sequence of Yersinia pestis, the causative agent of plague.";
RL Nature 413:523-527(2001).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=KIM10+ / Biovar Mediaevalis;
RX PubMed=12142430; DOI=10.1128/jb.184.16.4601-4611.2002;
RA Deng W., Burland V., Plunkett G. III, Boutin A., Mayhew G.F., Liss P.,
RA Perna N.T., Rose D.J., Mau B., Zhou S., Schwartz D.C., Fetherston J.D.,
RA Lindler L.E., Brubaker R.R., Plano G.V., Straley S.C., McDonough K.A.,
RA Nilles M.L., Matson J.S., Blattner F.R., Perry R.D.;
RT "Genome sequence of Yersinia pestis KIM.";
RL J. Bacteriol. 184:4601-4611(2002).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=91001 / Biovar Mediaevalis;
RX PubMed=15368893; DOI=10.1093/dnares/11.3.179;
RA Song Y., Tong Z., Wang J., Wang L., Guo Z., Han Y., Zhang J., Pei D.,
RA Zhou D., Qin H., Pang X., Han Y., Zhai J., Li M., Cui B., Qi Z., Jin L.,
RA Dai R., Chen F., Li S., Ye C., Du Z., Lin W., Wang J., Yu J., Yang H.,
RA Wang J., Huang P., Yang R.;
RT "Complete genome sequence of Yersinia pestis strain 91001, an isolate
RT avirulent to humans.";
RL DNA Res. 11:179-197(2004).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=2 H(+) + H2O + urea = CO2 + 2 NH4(+); Xref=Rhea:RHEA:20557,
CC ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:16199,
CC ChEBI:CHEBI:16526, ChEBI:CHEBI:28938; EC=3.5.1.5;
CC Evidence={ECO:0000255|HAMAP-Rule:MF_00739};
CC -!- PATHWAY: Nitrogen metabolism; urea degradation; CO(2) and NH(3) from
CC urea (urease route): step 1/1. {ECO:0000255|HAMAP-Rule:MF_00739}.
CC -!- SUBUNIT: Heterotrimer of UreA (gamma), UreB (beta) and UreC (alpha)
CC subunits. Three heterotrimers associate to form the active enzyme.
CC {ECO:0000255|HAMAP-Rule:MF_00739}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_00739}.
CC -!- SIMILARITY: Belongs to the urease gamma subunit family.
CC {ECO:0000255|HAMAP-Rule:MF_00739}.
CC -!- CAUTION: The last gene of this probable operon, ureD, gives rise to a
CC truncated protein. Absence of ureD prevents expression of active
CC urease. Correction of the mutation does not effect virulence in mice in
CC any detectable fashion, suggesting urease is not important in the
CC virulence of Y.pestis (PubMed:11119503). {ECO:0000305|PubMed:11119503}.
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DR EMBL; AF095636; AAC78632.1; -; Genomic_DNA.
DR EMBL; AL590842; CAL21284.1; -; Genomic_DNA.
DR EMBL; AE009952; AAM84812.1; -; Genomic_DNA.
DR EMBL; AE017042; AAS62666.1; -; Genomic_DNA.
DR PIR; AI0324; AI0324.
DR RefSeq; WP_002215288.1; NZ_WUCM01000006.1.
DR RefSeq; YP_002347614.1; NC_003143.1.
DR AlphaFoldDB; P69994; -.
DR SMR; P69994; -.
DR STRING; 214092.YPO2665; -.
DR PaxDb; P69994; -.
DR EnsemblBacteria; AAM84812; AAM84812; y1237.
DR EnsemblBacteria; AAS62666; AAS62666; YP_2466.
DR GeneID; 61905002; -.
DR GeneID; 67420525; -.
DR KEGG; ype:YPO2665; -.
DR KEGG; ypk:y1237; -.
DR KEGG; ypm:YP_2466; -.
DR PATRIC; fig|214092.21.peg.3099; -.
DR eggNOG; COG0831; Bacteria.
DR HOGENOM; CLU_145825_1_0_6; -.
DR OMA; MQLTPHE; -.
DR UniPathway; UPA00258; UER00370.
DR Proteomes; UP000000815; Chromosome.
DR Proteomes; UP000001019; Chromosome.
DR Proteomes; UP000002490; Chromosome.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0016151; F:nickel cation binding; IEA:InterPro.
DR GO; GO:0009039; F:urease activity; IEA:UniProtKB-UniRule.
DR GO; GO:0043419; P:urea catabolic process; IEA:UniProtKB-UniPathway.
DR CDD; cd00390; Urease_gamma; 1.
DR Gene3D; 3.30.280.10; -; 1.
DR HAMAP; MF_00739; Urease_gamma; 1.
DR InterPro; IPR012010; Urease_gamma.
DR InterPro; IPR002026; Urease_gamma/gamma-beta_su.
DR InterPro; IPR036463; Urease_gamma_sf.
DR Pfam; PF00547; Urease_gamma; 1.
DR PIRSF; PIRSF001223; Urease_gamma; 1.
DR SUPFAM; SSF54111; SSF54111; 1.
DR TIGRFAMs; TIGR00193; urease_gam; 1.
PE 3: Inferred from homology;
KW Cytoplasm; Hydrolase; Reference proteome.
FT CHAIN 1..100
FT /note="Urease subunit gamma"
FT /id="PRO_0000098066"
SQ SEQUENCE 100 AA; 11049 MW; 9590BEEA731E37FB CRC64;
MQLTPREVEK LMIYTLSDVA FKRKARGLKL NYPEAVSIIT VTAMEGARDG KSVEDVMKEA
SKVLTKDDVM DGVADLIPNV QVEAIFTDGS RLVTVHDPIK
