ID   UREA_SOYBN              Reviewed;         129 AA.
AC   P08298;
DT   01-AUG-1988, integrated into UniProtKB/Swiss-Prot.
DT   01-AUG-1988, sequence version 1.
DT   25-MAY-2022, entry version 105.
DE   RecName: Full=Urease;
DE            EC=3.5.1.5;
DE   AltName: Full=Urea amidohydrolase;
DE   Flags: Fragment;
OS   Glycine max (Soybean) (Glycine hispida).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC   rosids; fabids; Fabales; Fabaceae; Papilionoideae; 50 kb inversion clade;
OC   NPAAA clade; indigoferoid/millettioid clade; Phaseoleae; Glycine;
OC   Glycine subgen. Soja.
OX   NCBI_TaxID=3847;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=3609752; DOI=10.1016/0378-1119(87)90345-3;
RA   Krueger R.W., Holland M.A., Chisholm D., Polacco J.C.;
RT   "Recovery of a soybean urease genomic clone by sequential library screening
RT   with two synthetic oligodeoxynucleotides.";
RL   Gene 54:41-50(1987).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=2 H(+) + H2O + urea = CO2 + 2 NH4(+); Xref=Rhea:RHEA:20557,
CC         ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:16199,
CC         ChEBI:CHEBI:16526, ChEBI:CHEBI:28938; EC=3.5.1.5;
CC         Evidence={ECO:0000255|PROSITE-ProRule:PRU00700};
CC   -!- COFACTOR:
CC       Name=Ni cation; Xref=ChEBI:CHEBI:25516; Evidence={ECO:0000305};
CC       Note=Binds 2 nickel ions per subunit. {ECO:0000305};
CC   -!- PATHWAY: Nitrogen metabolism; urea degradation; CO(2) and NH(3) from
CC       urea (urease route): step 1/1.
CC   -!- SUBUNIT: Homohexamer.
CC   -!- SIMILARITY: Belongs to the metallo-dependent hydrolases superfamily.
CC       Urease alpha subunit family.
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DR   EMBL; M16772; AAA34018.1; -; Genomic_DNA.
DR   PIR; T08993; T08993.
DR   AlphaFoldDB; P08298; -.
DR   SMR; P08298; -.
DR   STRING; 3847.GLYMA11G37250.1; -.
DR   eggNOG; ENOG502QPKB; Eukaryota.
DR   UniPathway; UPA00258; UER00370.
DR   Proteomes; UP000008827; Unplaced.
DR   GO; GO:0016151; F:nickel cation binding; IEA:InterPro.
DR   GO; GO:0009039; F:urease activity; IEA:UniProtKB-EC.
DR   GO; GO:0043419; P:urea catabolic process; IEA:UniProtKB-UniPathway.
DR   Gene3D; 2.30.40.10; -; 1.
DR   InterPro; IPR006680; Amidohydro-rel.
DR   InterPro; IPR011059; Metal-dep_hydrolase_composite.
DR   InterPro; IPR032466; Metal_Hydrolase.
DR   InterPro; IPR005848; Urease_asu.
DR   InterPro; IPR017951; Urease_asu_c.
DR   Pfam; PF01979; Amidohydro_1; 1.
DR   PRINTS; PR01752; UREASE.
DR   SUPFAM; SSF51338; SSF51338; 1.
DR   SUPFAM; SSF51556; SSF51556; 1.
DR   PROSITE; PS51368; UREASE_3; 1.
PE   3: Inferred from homology;
KW   Hydrolase; Metal-binding; Nickel; Reference proteome.
FT   CHAIN           <1..>129
FT                   /note="Urease"
FT                   /id="PRO_0000067525"
FT   DOMAIN          <1..>129
FT                   /note="Urease"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00700"
FT   REGION          1..24
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   NON_TER         1
FT   NON_TER         129
SQ   SEQUENCE   129 AA;  14037 MW;  F94A700DFF71ED35 CRC64;
     VISRTWQTAD KMKSQRGPLQ PGEDNDNFRI KRYVAKYTIN PAIANGFSQY VGSVEAGKLA
     DLVLWKPSFF GAKPEMVIKG GEVAYANMGD PNASIPTPEP VIMRPMFGTL GKAGSSLSIA
     FVSKAWLNQ