ID   URED1_BRUA2             Reviewed;         280 AA.
AC   Q2YPD8; Q93T84;
DT   10-JUN-2008, integrated into UniProtKB/Swiss-Prot.
DT   07-FEB-2006, sequence version 1.
DT   25-MAY-2022, entry version 68.
DE   RecName: Full=Urease accessory protein UreD 1 {ECO:0000255|HAMAP-Rule:MF_01384};
GN   Name=ureD1 {ECO:0000255|HAMAP-Rule:MF_01384}; Synonyms=ureD-1;
GN   OrderedLocusNames=BAB1_0297;
OS   Brucella abortus (strain 2308).
OC   Bacteria; Proteobacteria; Alphaproteobacteria; Hyphomicrobiales;
OC   Brucellaceae; Brucella/Ochrobactrum group; Brucella.
OX   NCBI_TaxID=359391;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND ROLE IN VIRULENCE.
RX   PubMed=17101645; DOI=10.1128/iai.01244-06;
RA   Sangari F.J., Seoane A., Rodriguez M.C., Aguero J., Garcia Lobo J.M.;
RT   "Characterization of the urease operon of Brucella abortus and assessment
RT   of its role in virulence of the bacterium.";
RL   Infect. Immun. 75:774-780(2007).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=2308;
RX   PubMed=16299333; DOI=10.1128/iai.73.12.8353-8361.2005;
RA   Chain P.S., Comerci D.J., Tolmasky M.E., Larimer F.W., Malfatti S.A.,
RA   Vergez L.M., Aguero F., Land M.L., Ugalde R.A., Garcia E.;
RT   "Whole-genome analyses of speciation events in pathogenic Brucellae.";
RL   Infect. Immun. 73:8353-8361(2005).
CC   -!- FUNCTION: Required for maturation of urease via the functional
CC       incorporation of the urease nickel metallocenter. {ECO:0000255|HAMAP-
CC       Rule:MF_01384}.
CC   -!- FUNCTION: Disruption of the ure1 gene cluster suggests that it protects
CC       brucellae during their passage through the stomach. The major route of
CC       infection in human brucellosis is oral. {ECO:0000269|PubMed:17101645}.
CC   -!- SUBUNIT: UreD, UreF and UreG form a complex that acts as a GTP-
CC       hydrolysis-dependent molecular chaperone, activating the urease
CC       apoprotein by helping to assemble the nickel containing metallocenter
CC       of UreC. The UreE protein probably delivers the nickel.
CC       {ECO:0000255|HAMAP-Rule:MF_01384}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_01384}.
CC   -!- SIMILARITY: Belongs to the UreD family. {ECO:0000255|HAMAP-
CC       Rule:MF_01384}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAK51066.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR   EMBL; AF361941; AAK51066.1; ALT_INIT; Genomic_DNA.
DR   EMBL; AM040264; CAJ10253.1; -; Genomic_DNA.
DR   RefSeq; WP_002963430.1; NZ_KN046823.1.
DR   AlphaFoldDB; Q2YPD8; -.
DR   SMR; Q2YPD8; -.
DR   STRING; 359391.BAB1_0297; -.
DR   EnsemblBacteria; CAJ10253; CAJ10253; BAB1_0297.
DR   GeneID; 3789049; -.
DR   KEGG; bmf:BAB1_0297; -.
DR   PATRIC; fig|359391.11.peg.2344; -.
DR   HOGENOM; CLU_056339_2_0_5; -.
DR   OMA; MARFCAQ; -.
DR   PhylomeDB; Q2YPD8; -.
DR   Proteomes; UP000002719; Chromosome I.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0016151; F:nickel cation binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0006807; P:nitrogen compound metabolic process; IEA:InterPro.
DR   HAMAP; MF_01384; UreD; 1.
DR   InterPro; IPR002669; UreD.
DR   PANTHER; PTHR33643; PTHR33643; 1.
DR   Pfam; PF01774; UreD; 1.
PE   3: Inferred from homology;
KW   Chaperone; Cytoplasm; Nickel insertion; Reference proteome; Virulence.
FT   CHAIN           1..280
FT                   /note="Urease accessory protein UreD 1"
FT                   /id="PRO_0000340419"
SQ   SEQUENCE   280 AA;  30256 MW;  3FE5CA77016C952C CRC64;
     MLIINDNNLS GLSLQRVNGT GELSVQFKDG RSRISRLYQE GAAKIRMPQA VTGPLEAILI
     NTSGGLTGGD RLKWDVALDD GASAVITTQA CERIYRSGGG EARIATRLKA AKGTRLAWLP
     QETILFNRSI LSRRLDVELE EGAQMLVVEA TVFGRLAMGE RVVAARFADR WRVRLGGRVI
     HAEEFRLGPD VGAELQAPAV AGGACAMATV LMVCEQAGRY LETARAIIGE EGGCSLWRVG
     KASKLVVRLY APDSYALRRR LCPLVALLNG KAGLPKVWTI