ID   URED1_BRUME             Reviewed;         280 AA.
AC   Q8YF70;
DT   10-JUN-2008, integrated into UniProtKB/Swiss-Prot.
DT   10-JUN-2008, sequence version 2.
DT   03-AUG-2022, entry version 83.
DE   RecName: Full=Urease accessory protein UreD 1 {ECO:0000255|HAMAP-Rule:MF_01384};
GN   Name=ureD1 {ECO:0000255|HAMAP-Rule:MF_01384}; OrderedLocusNames=BMEI1655;
OS   Brucella melitensis biotype 1 (strain 16M / ATCC 23456 / NCTC 10094).
OC   Bacteria; Proteobacteria; Alphaproteobacteria; Hyphomicrobiales;
OC   Brucellaceae; Brucella/Ochrobactrum group; Brucella.
OX   NCBI_TaxID=224914;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=16M / ATCC 23456 / NCTC 10094;
RX   PubMed=11756688; DOI=10.1073/pnas.221575398;
RA   DelVecchio V.G., Kapatral V., Redkar R.J., Patra G., Mujer C., Los T.,
RA   Ivanova N., Anderson I., Bhattacharyya A., Lykidis A., Reznik G.,
RA   Jablonski L., Larsen N., D'Souza M., Bernal A., Mazur M., Goltsman E.,
RA   Selkov E., Elzer P.H., Hagius S., O'Callaghan D., Letesson J.-J.,
RA   Haselkorn R., Kyrpides N.C., Overbeek R.;
RT   "The genome sequence of the facultative intracellular pathogen Brucella
RT   melitensis.";
RL   Proc. Natl. Acad. Sci. U.S.A. 99:443-448(2002).
CC   -!- FUNCTION: Required for maturation of urease via the functional
CC       incorporation of the urease nickel metallocenter. {ECO:0000255|HAMAP-
CC       Rule:MF_01384}.
CC   -!- SUBUNIT: UreD, UreF and UreG form a complex that acts as a GTP-
CC       hydrolysis-dependent molecular chaperone, activating the urease
CC       apoprotein by helping to assemble the nickel containing metallocenter
CC       of UreC. The UreE protein probably delivers the nickel.
CC       {ECO:0000255|HAMAP-Rule:MF_01384}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_01384}.
CC   -!- SIMILARITY: Belongs to the UreD family. {ECO:0000255|HAMAP-
CC       Rule:MF_01384}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAL52836.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR   EMBL; AE008917; AAL52836.1; ALT_INIT; Genomic_DNA.
DR   PIR; AI3458; AI3458.
DR   RefSeq; WP_004682792.1; NZ_GG703778.1.
DR   AlphaFoldDB; Q8YF70; -.
DR   SMR; Q8YF70; -.
DR   STRING; 224914.BMEI1655; -.
DR   EnsemblBacteria; AAL52836; AAL52836; BMEI1655.
DR   GeneID; 29594505; -.
DR   KEGG; bme:BMEI1655; -.
DR   PATRIC; fig|224914.52.peg.1935; -.
DR   eggNOG; COG0829; Bacteria.
DR   PhylomeDB; Q8YF70; -.
DR   Proteomes; UP000000419; Chromosome I.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0016151; F:nickel cation binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0006807; P:nitrogen compound metabolic process; IEA:InterPro.
DR   HAMAP; MF_01384; UreD; 1.
DR   InterPro; IPR002669; UreD.
DR   PANTHER; PTHR33643; PTHR33643; 1.
DR   Pfam; PF01774; UreD; 1.
PE   3: Inferred from homology;
KW   Chaperone; Cytoplasm; Nickel insertion.
FT   CHAIN           1..280
FT                   /note="Urease accessory protein UreD 1"
FT                   /id="PRO_0000340423"
SQ   SEQUENCE   280 AA;  30234 MW;  9155CD1DBDBAFF90 CRC64;
     MLIINDNNLS GLSLQRVNGT GELSVQFKDG RSRISRLYQE GAAKIRMPQA VTGPLEAILI
     NTSGGLTGGD RLKWDVALDD GASAVITTQA CERIYRSGGG EARIATRLKA AKGTRLAWLP
     QETILFNRSI LSRRLDVELE EGAQMLVVEA TVFGRLAMGE RVVAARFADR WRVRLGGRVI
     HAEEFRLGPD VGAELQATAV AGGACAMATV LMVCEQAGRH LETARAIIGE EGGCSLWRVG
     KASKLVVRLY APDSYALRRR LCPLVALLNG KAGLPKVWTI