ID   URED1_METEP             Reviewed;         294 AA.
AC   A9W1Z5;
DT   02-SEP-2008, integrated into UniProtKB/Swiss-Prot.
DT   05-FEB-2008, sequence version 1.
DT   03-AUG-2022, entry version 59.
DE   RecName: Full=Urease accessory protein UreD 1 {ECO:0000255|HAMAP-Rule:MF_01384};
GN   Name=ureD1 {ECO:0000255|HAMAP-Rule:MF_01384}; OrderedLocusNames=Mext_1199;
OS   Methylorubrum extorquens (strain PA1) (Methylobacterium extorquens).
OC   Bacteria; Proteobacteria; Alphaproteobacteria; Hyphomicrobiales;
OC   Methylobacteriaceae; Methylorubrum.
OX   NCBI_TaxID=419610;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=PA1;
RG   US DOE Joint Genome Institute;
RA   Copeland A., Lucas S., Lapidus A., Barry K., Glavina del Rio T., Dalin E.,
RA   Tice H., Pitluck S., Saunders E., Brettin T., Bruce D., Detter J.C.,
RA   Han C., Schmutz J., Larimer F., Land M., Hauser L., Kyrpides N., Kim E.,
RA   Marx C., Richardson P.;
RT   "Complete sequence of Methylobacterium extorquens PA1.";
RL   Submitted (DEC-2007) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Required for maturation of urease via the functional
CC       incorporation of the urease nickel metallocenter. {ECO:0000255|HAMAP-
CC       Rule:MF_01384}.
CC   -!- SUBUNIT: UreD, UreF and UreG form a complex that acts as a GTP-
CC       hydrolysis-dependent molecular chaperone, activating the urease
CC       apoprotein by helping to assemble the nickel containing metallocenter
CC       of UreC. The UreE protein probably delivers the nickel.
CC       {ECO:0000255|HAMAP-Rule:MF_01384}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_01384}.
CC   -!- SIMILARITY: Belongs to the UreD family. {ECO:0000255|HAMAP-
CC       Rule:MF_01384}.
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DR   EMBL; CP000908; ABY29601.1; -; Genomic_DNA.
DR   RefSeq; WP_012252855.1; NC_010172.1.
DR   AlphaFoldDB; A9W1Z5; -.
DR   SMR; A9W1Z5; -.
DR   STRING; 419610.Mext_1199; -.
DR   EnsemblBacteria; ABY29601; ABY29601; Mext_1199.
DR   KEGG; mex:Mext_1199; -.
DR   eggNOG; COG0829; Bacteria.
DR   HOGENOM; CLU_056339_1_1_5; -.
DR   OMA; PYPFHIT; -.
DR   BioCyc; MEXT419610:MEXT_RS06035-MON; -.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0016151; F:nickel cation binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0006807; P:nitrogen compound metabolic process; IEA:InterPro.
DR   HAMAP; MF_01384; UreD; 1.
DR   InterPro; IPR002669; UreD.
DR   PANTHER; PTHR33643; PTHR33643; 1.
DR   Pfam; PF01774; UreD; 1.
PE   3: Inferred from homology;
KW   Chaperone; Cytoplasm; Nickel insertion.
FT   CHAIN           1..294
FT                   /note="Urease accessory protein UreD 1"
FT                   /id="PRO_0000346572"
FT   REGION          1..22
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   294 AA;  30750 MW;  9E4D20E2A6070D22 CRC64;
     MALSLDGLPE KPAPAEAPSP PVGRRVQASL VFARGGRTTV LSRQVVPYPF HITRAFRMHP
     ESPDLATLYL QSASGGLYAA DHLTLAIAAR AGARAHVTTQ AGTVVHRGGP EPSRQETRLT
     IAADAFLALN PDPLILFPGA HLAVSTEITA EPGARAIVTE SVACHDPVGE GRPFDRLDLG
     LTIRDPEGRA LVRERSRIDG RAFTAPDSPM GPHRAYGTMV VLGAPDDARL AGLHLRQAAD
     AAGCLTGVSP LPNGAGLGLR LLAPDGGTLS AGMDAVFRIV FETLSGCAPG RRRK