ID   URED1_METRJ             Reviewed;         288 AA.
AC   B1LZY1;
DT   02-SEP-2008, integrated into UniProtKB/Swiss-Prot.
DT   29-APR-2008, sequence version 1.
DT   25-MAY-2022, entry version 54.
DE   RecName: Full=Urease accessory protein UreD 1 {ECO:0000255|HAMAP-Rule:MF_01384};
GN   Name=ureD1 {ECO:0000255|HAMAP-Rule:MF_01384};
GN   OrderedLocusNames=Mrad2831_2469;
OS   Methylobacterium radiotolerans (strain ATCC 27329 / DSM 1819 / JCM 2831 /
OS   NBRC 15690 / NCIMB 10815 / 0-1).
OC   Bacteria; Proteobacteria; Alphaproteobacteria; Hyphomicrobiales;
OC   Methylobacteriaceae; Methylobacterium.
OX   NCBI_TaxID=426355;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 27329 / DSM 1819 / JCM 2831 / NBRC 15690 / NCIMB 10815 / 0-1;
RG   US DOE Joint Genome Institute;
RA   Copeland A., Lucas S., Lapidus A., Glavina del Rio T., Dalin E., Tice H.,
RA   Bruce D., Goodwin L., Pitluck S., Kiss H., Brettin T., Detter J.C., Han C.,
RA   Kuske C.R., Schmutz J., Larimer F., Land M., Hauser L., Kyrpides N.,
RA   Mikhailova N., Marx C.J., Richardson P.;
RT   "Complete sequence of chromosome of Methylobacterium radiotolerans JCM
RT   2831.";
RL   Submitted (MAR-2008) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Required for maturation of urease via the functional
CC       incorporation of the urease nickel metallocenter. {ECO:0000255|HAMAP-
CC       Rule:MF_01384}.
CC   -!- SUBUNIT: UreD, UreF and UreG form a complex that acts as a GTP-
CC       hydrolysis-dependent molecular chaperone, activating the urease
CC       apoprotein by helping to assemble the nickel containing metallocenter
CC       of UreC. The UreE protein probably delivers the nickel.
CC       {ECO:0000255|HAMAP-Rule:MF_01384}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_01384}.
CC   -!- SIMILARITY: Belongs to the UreD family. {ECO:0000255|HAMAP-
CC       Rule:MF_01384}.
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DR   EMBL; CP001001; ACB24464.1; -; Genomic_DNA.
DR   RefSeq; WP_012319437.1; NC_010505.1.
DR   AlphaFoldDB; B1LZY1; -.
DR   SMR; B1LZY1; -.
DR   STRING; 426355.Mrad2831_2469; -.
DR   EnsemblBacteria; ACB24464; ACB24464; Mrad2831_2469.
DR   KEGG; mrd:Mrad2831_2469; -.
DR   PATRIC; fig|426355.14.peg.2547; -.
DR   eggNOG; COG0829; Bacteria.
DR   HOGENOM; CLU_056339_2_0_5; -.
DR   OMA; MARFCAQ; -.
DR   OrthoDB; 1764668at2; -.
DR   Proteomes; UP000006589; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0016151; F:nickel cation binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0006807; P:nitrogen compound metabolic process; IEA:InterPro.
DR   HAMAP; MF_01384; UreD; 1.
DR   InterPro; IPR002669; UreD.
DR   PANTHER; PTHR33643; PTHR33643; 1.
DR   Pfam; PF01774; UreD; 1.
PE   3: Inferred from homology;
KW   Chaperone; Cytoplasm; Nickel insertion; Reference proteome.
FT   CHAIN           1..288
FT                   /note="Urease accessory protein UreD 1"
FT                   /id="PRO_0000346578"
FT   REGION          1..35
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   288 AA;  29968 MW;  7EF8B377F7B7F8CD CRC64;
     MHGPLAPAPS PERLGAAPAR QRSDGRIRLR VGPARPGGGT RILDLAEAGP SRLRFPRGTC
     ALEAVLVNTA GGVACGDSFA IDLALEPGAD LVLTTTAAEK IYRSDGPVSR IANTLTLGEG
     AGLAWLPQET ILFDRARVRR RFEADLADGA ALIAAEVVAF GRAARGERIV DGLFADSWRI
     RRGGRLAYAD SVLLEGPISD HLARPAIGGG ARACATILDV SPGAEARLEE ARARLAEAAS
     PGTTAAASAW NGHLAVRALG DAVGPLRGLV ARFLAGYRAL PMPRVWQS