ID   URED2_BRASB             Reviewed;         286 AA.
AC   A5EJY2;
DT   02-SEP-2008, integrated into UniProtKB/Swiss-Prot.
DT   12-JUN-2007, sequence version 1.
DT   25-MAY-2022, entry version 57.
DE   RecName: Full=Urease accessory protein UreD 2 {ECO:0000255|HAMAP-Rule:MF_01384};
GN   Name=ureD2 {ECO:0000255|HAMAP-Rule:MF_01384}; OrderedLocusNames=BBta_4440;
OS   Bradyrhizobium sp. (strain BTAi1 / ATCC BAA-1182).
OC   Bacteria; Proteobacteria; Alphaproteobacteria; Hyphomicrobiales;
OC   Bradyrhizobiaceae; Bradyrhizobium; unclassified Bradyrhizobium.
OX   NCBI_TaxID=288000;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=BTAi1 / ATCC BAA-1182;
RX   PubMed=17540897; DOI=10.1126/science.1139548;
RA   Giraud E., Moulin L., Vallenet D., Barbe V., Cytryn E., Avarre J.-C.,
RA   Jaubert M., Simon D., Cartieaux F., Prin Y., Bena G., Hannibal L.,
RA   Fardoux J., Kojadinovic M., Vuillet L., Lajus A., Cruveiller S., Rouy Z.,
RA   Mangenot S., Segurens B., Dossat C., Franck W.L., Chang W.-S., Saunders E.,
RA   Bruce D., Richardson P., Normand P., Dreyfus B., Pignol D., Stacey G.,
RA   Emerich D., Vermeglio A., Medigue C., Sadowsky M.;
RT   "Legumes symbioses: absence of nod genes in photosynthetic bradyrhizobia.";
RL   Science 316:1307-1312(2007).
CC   -!- FUNCTION: Required for maturation of urease via the functional
CC       incorporation of the urease nickel metallocenter. {ECO:0000255|HAMAP-
CC       Rule:MF_01384}.
CC   -!- SUBUNIT: UreD, UreF and UreG form a complex that acts as a GTP-
CC       hydrolysis-dependent molecular chaperone, activating the urease
CC       apoprotein by helping to assemble the nickel containing metallocenter
CC       of UreC. The UreE protein probably delivers the nickel.
CC       {ECO:0000255|HAMAP-Rule:MF_01384}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_01384}.
CC   -!- SIMILARITY: Belongs to the UreD family. {ECO:0000255|HAMAP-
CC       Rule:MF_01384}.
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DR   EMBL; CP000494; ABQ36476.1; -; Genomic_DNA.
DR   RefSeq; WP_012044472.1; NC_009485.1.
DR   AlphaFoldDB; A5EJY2; -.
DR   SMR; A5EJY2; -.
DR   STRING; 288000.BBta_4440; -.
DR   EnsemblBacteria; ABQ36476; ABQ36476; BBta_4440.
DR   KEGG; bbt:BBta_4440; -.
DR   eggNOG; COG0829; Bacteria.
DR   HOGENOM; CLU_056339_1_1_5; -.
DR   OMA; TDAFTMH; -.
DR   OrthoDB; 1764668at2; -.
DR   Proteomes; UP000000246; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0016151; F:nickel cation binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0006807; P:nitrogen compound metabolic process; IEA:InterPro.
DR   HAMAP; MF_01384; UreD; 1.
DR   InterPro; IPR002669; UreD.
DR   Pfam; PF01774; UreD; 1.
PE   3: Inferred from homology;
KW   Chaperone; Cytoplasm; Nickel insertion.
FT   CHAIN           1..286
FT                   /note="Urease accessory protein UreD 2"
FT                   /id="PRO_0000346555"
SQ   SEQUENCE   286 AA;  30812 MW;  CD7309AE765C00C2 CRC64;
     MSASAPEPPR LDLSFVRRGG RTVIDRRLFA WPFVLTRSFH TDGARPDLLS VILQTGSGAV
     HGEDRLTQRF TLREGAAVSV TTQGATSVHR AEPGARAVEQ VQLRVAAGAS LDYRPEPRIL
     FPDAALCQVL ELDCAADAVA LVTDAFTMHD PDGQGRLFRE LDSTVIVRRP SQEPLLIDRM
     QLCDPGTALF KGRRAFGSAV LMLPDMHDRA AIRLRVIDTL AHIDDLYAAA SLLPQSVGIG
     IRLAARELRQ LRAGFDAVAA LVREIDLGAR AAQAPSAAAT ARPTAA