ID   URED2_BRASO             Reviewed;         286 AA.
AC   A4YV90;
DT   02-SEP-2008, integrated into UniProtKB/Swiss-Prot.
DT   29-MAY-2007, sequence version 1.
DT   03-AUG-2022, entry version 61.
DE   RecName: Full=Urease accessory protein UreD 2 {ECO:0000255|HAMAP-Rule:MF_01384};
GN   Name=ureD2 {ECO:0000255|HAMAP-Rule:MF_01384}; OrderedLocusNames=BRADO4064;
OS   Bradyrhizobium sp. (strain ORS 278).
OC   Bacteria; Proteobacteria; Alphaproteobacteria; Hyphomicrobiales;
OC   Bradyrhizobiaceae; Bradyrhizobium; unclassified Bradyrhizobium.
OX   NCBI_TaxID=114615;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ORS 278;
RX   PubMed=17540897; DOI=10.1126/science.1139548;
RA   Giraud E., Moulin L., Vallenet D., Barbe V., Cytryn E., Avarre J.-C.,
RA   Jaubert M., Simon D., Cartieaux F., Prin Y., Bena G., Hannibal L.,
RA   Fardoux J., Kojadinovic M., Vuillet L., Lajus A., Cruveiller S., Rouy Z.,
RA   Mangenot S., Segurens B., Dossat C., Franck W.L., Chang W.-S., Saunders E.,
RA   Bruce D., Richardson P., Normand P., Dreyfus B., Pignol D., Stacey G.,
RA   Emerich D., Vermeglio A., Medigue C., Sadowsky M.;
RT   "Legumes symbioses: absence of nod genes in photosynthetic bradyrhizobia.";
RL   Science 316:1307-1312(2007).
CC   -!- FUNCTION: Required for maturation of urease via the functional
CC       incorporation of the urease nickel metallocenter. {ECO:0000255|HAMAP-
CC       Rule:MF_01384}.
CC   -!- SUBUNIT: UreD, UreF and UreG form a complex that acts as a GTP-
CC       hydrolysis-dependent molecular chaperone, activating the urease
CC       apoprotein by helping to assemble the nickel containing metallocenter
CC       of UreC. The UreE protein probably delivers the nickel.
CC       {ECO:0000255|HAMAP-Rule:MF_01384}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_01384}.
CC   -!- SIMILARITY: Belongs to the UreD family. {ECO:0000255|HAMAP-
CC       Rule:MF_01384}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; CU234118; CAL77816.1; -; Genomic_DNA.
DR   RefSeq; WP_011926949.1; NC_009445.1.
DR   AlphaFoldDB; A4YV90; -.
DR   SMR; A4YV90; -.
DR   STRING; 114615.BRADO4064; -.
DR   EnsemblBacteria; CAL77816; CAL77816; BRADO4064.
DR   KEGG; bra:BRADO4064; -.
DR   eggNOG; COG0829; Bacteria.
DR   HOGENOM; CLU_056339_1_1_5; -.
DR   OMA; TDAFTMH; -.
DR   OrthoDB; 1764668at2; -.
DR   BioCyc; BSP114615:BRADO_RS18925-MON; -.
DR   Proteomes; UP000001994; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0016151; F:nickel cation binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0006807; P:nitrogen compound metabolic process; IEA:InterPro.
DR   HAMAP; MF_01384; UreD; 1.
DR   InterPro; IPR002669; UreD.
DR   PANTHER; PTHR33643; PTHR33643; 1.
DR   Pfam; PF01774; UreD; 1.
PE   3: Inferred from homology;
KW   Chaperone; Cytoplasm; Nickel insertion; Reference proteome.
FT   CHAIN           1..286
FT                   /note="Urease accessory protein UreD 2"
FT                   /id="PRO_0000346556"
SQ   SEQUENCE   286 AA;  30931 MW;  0A79C7063F5C85A4 CRC64;
     MSDLSPDKPR LDLSFVRRGS RTVIDRRLFA WPFVLTRSFH TDAARPDCLS VILQTGSGAV
     HGEDRLTQRL TLHAGAAVCV TTQGATSVHR AEPGARAVEH VLLHVEAGAS LDYRPEPRIL
     FPDAALCQVL DLECAADAAA LVTDAFTMHD PDGQGRLFRE LDSKLIVRRQ GKEPLLIDRM
     HLRDPATALF NGRRAFGSAV LMLPPTHDRA AIRLRLADAF ARIDDLYAAA SLLQDGAGIG
     VRFAAREVRQ LRAGFDAVAA VVREIDLGAR AAQAPRAAAT ARPTAA