ID   URED2_BRUA4             Reviewed;         274 AA.
AC   A6X1Q4;
DT   10-JUN-2008, integrated into UniProtKB/Swiss-Prot.
DT   21-AUG-2007, sequence version 1.
DT   25-MAY-2022, entry version 67.
DE   RecName: Full=Urease accessory protein UreD 2 {ECO:0000255|HAMAP-Rule:MF_01384};
GN   Name=ureD2 {ECO:0000255|HAMAP-Rule:MF_01384}; OrderedLocusNames=Oant_2444;
OS   Brucella anthropi (strain ATCC 49188 / DSM 6882 / CCUG 24695 / JCM 21032 /
OS   LMG 3331 / NBRC 15819 / NCTC 12168 / Alc 37) (Ochrobactrum anthropi).
OC   Bacteria; Proteobacteria; Alphaproteobacteria; Hyphomicrobiales;
OC   Brucellaceae; Brucella/Ochrobactrum group; Brucella.
OX   NCBI_TaxID=439375;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 49188 / DSM 6882 / CCUG 24695 / JCM 21032 / LMG 3331 / NBRC
RC   15819 / NCTC 12168 / Alc 37;
RX   PubMed=21685287; DOI=10.1128/jb.05335-11;
RA   Chain P.S., Lang D.M., Comerci D.J., Malfatti S.A., Vergez L.M., Shin M.,
RA   Ugalde R.A., Garcia E., Tolmasky M.E.;
RT   "Genome of Ochrobactrum anthropi ATCC 49188 T, a versatile opportunistic
RT   pathogen and symbiont of several eukaryotic hosts.";
RL   J. Bacteriol. 193:4274-4275(2011).
CC   -!- FUNCTION: Required for maturation of urease via the functional
CC       incorporation of the urease nickel metallocenter. {ECO:0000255|HAMAP-
CC       Rule:MF_01384}.
CC   -!- SUBUNIT: UreD, UreF and UreG form a complex that acts as a GTP-
CC       hydrolysis-dependent molecular chaperone, activating the urease
CC       apoprotein by helping to assemble the nickel containing metallocenter
CC       of UreC. The UreE protein probably delivers the nickel.
CC       {ECO:0000255|HAMAP-Rule:MF_01384}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_01384}.
CC   -!- SIMILARITY: Belongs to the UreD family. {ECO:0000255|HAMAP-
CC       Rule:MF_01384}.
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DR   EMBL; CP000758; ABS15158.1; -; Genomic_DNA.
DR   RefSeq; WP_012092276.1; NC_009667.1.
DR   AlphaFoldDB; A6X1Q4; -.
DR   SMR; A6X1Q4; -.
DR   STRING; 439375.Oant_2444; -.
DR   EnsemblBacteria; ABS15158; ABS15158; Oant_2444.
DR   KEGG; oan:Oant_2444; -.
DR   PATRIC; fig|439375.7.peg.2579; -.
DR   eggNOG; COG0829; Bacteria.
DR   HOGENOM; CLU_056339_0_0_5; -.
DR   OMA; CHHVLVH; -.
DR   OrthoDB; 1764668at2; -.
DR   PhylomeDB; A6X1Q4; -.
DR   Proteomes; UP000002301; Chromosome 1.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0016151; F:nickel cation binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0006807; P:nitrogen compound metabolic process; IEA:InterPro.
DR   HAMAP; MF_01384; UreD; 1.
DR   InterPro; IPR002669; UreD.
DR   PANTHER; PTHR33643; PTHR33643; 1.
DR   Pfam; PF01774; UreD; 1.
PE   3: Inferred from homology;
KW   Chaperone; Cytoplasm; Nickel insertion; Reference proteome.
FT   CHAIN           1..274
FT                   /note="Urease accessory protein UreD 2"
FT                   /id="PRO_0000340469"
SQ   SEQUENCE   274 AA;  30237 MW;  6C8E55BF9B5CF6F0 CRC64;
     MSTGWHAELE LRFEHNREVT RLMRRRHVGP LAVQQPFYPE KDGSAHVYLL HPPGGVAGDD
     VLDISCFLGR GARAVLTTPG ATKFYRSERG QSTQTTRIDV GEGGICEYLP QETIVFDGAK
     ASIGTKVFLS GDAVYLGWDI ISLGRPACQE SFDTGEVRQR IEIFRDGKPI WFEQFRLHGA
     DPALNAAFAF CAKPIVATMV YAGPADESAL HAIREAVGDA ARNLFSVSRL ERVIVCRYLG
     GRMSEAKTLF RKAWEVLRET GLGKPAAAPR IWAT