ID   URED2_BRUC2             Reviewed;         302 AA.
AC   A9M618;
DT   10-JUN-2008, integrated into UniProtKB/Swiss-Prot.
DT   05-FEB-2008, sequence version 1.
DT   25-MAY-2022, entry version 54.
DE   RecName: Full=Urease accessory protein UreD 2 {ECO:0000255|HAMAP-Rule:MF_01384};
GN   Name=ureD2 {ECO:0000255|HAMAP-Rule:MF_01384}; OrderedLocusNames=BCAN_A1389;
OS   Brucella canis (strain ATCC 23365 / NCTC 10854).
OC   Bacteria; Proteobacteria; Alphaproteobacteria; Hyphomicrobiales;
OC   Brucellaceae; Brucella/Ochrobactrum group; Brucella.
OX   NCBI_TaxID=483179;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 23365 / NCTC 10854;
RA   Setubal J.C., Bowns C., Boyle S., Crasta O.R., Czar M.J., Dharmanolla C.,
RA   Gillespie J.J., Kenyon R.W., Lu J., Mane S., Mohapatra S., Nagrani S.,
RA   Purkayastha A., Rajasimha H.K., Shallom J.M., Shallom S., Shukla M.,
RA   Snyder E.E., Sobral B.W., Wattam A.R., Will R., Williams K., Yoo H.,
RA   Bruce D., Detter C., Munk C., Brettin T.S.;
RT   "Brucella canis ATCC 23365 whole genome shotgun sequencing project.";
RL   Submitted (OCT-2007) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Required for maturation of urease via the functional
CC       incorporation of the urease nickel metallocenter. {ECO:0000255|HAMAP-
CC       Rule:MF_01384}.
CC   -!- SUBUNIT: UreD, UreF and UreG form a complex that acts as a GTP-
CC       hydrolysis-dependent molecular chaperone, activating the urease
CC       apoprotein by helping to assemble the nickel containing metallocenter
CC       of UreC. The UreE protein probably delivers the nickel.
CC       {ECO:0000255|HAMAP-Rule:MF_01384}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_01384}.
CC   -!- SIMILARITY: Belongs to the UreD family. {ECO:0000255|HAMAP-
CC       Rule:MF_01384}.
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DR   EMBL; CP000872; ABX62423.1; -; Genomic_DNA.
DR   RefSeq; WP_004691636.1; NC_010103.1.
DR   AlphaFoldDB; A9M618; -.
DR   SMR; A9M618; -.
DR   EnsemblBacteria; ABX62423; ABX62423; BCAN_A1389.
DR   GeneID; 55591022; -.
DR   KEGG; bcs:BCAN_A1389; -.
DR   HOGENOM; CLU_056339_1_0_5; -.
DR   OMA; IPFENAH; -.
DR   PhylomeDB; A9M618; -.
DR   Proteomes; UP000001385; Chromosome I.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0016151; F:nickel cation binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0006807; P:nitrogen compound metabolic process; IEA:InterPro.
DR   HAMAP; MF_01384; UreD; 1.
DR   InterPro; IPR002669; UreD.
DR   PANTHER; PTHR33643; PTHR33643; 1.
DR   Pfam; PF01774; UreD; 1.
PE   3: Inferred from homology;
KW   Chaperone; Cytoplasm; Nickel insertion.
FT   CHAIN           1..302
FT                   /note="Urease accessory protein UreD 2"
FT                   /id="PRO_0000340422"
SQ   SEQUENCE   302 AA;  33715 MW;  BD229C7F2E437E06 CRC64;
     MLGKARELAN YQDEPEQLPT GSFGKNAFLR LGFERRPERT VLATLHRRAP LIVQQALYWD
     EGMPTLPCVS IISNAGGILQ GDRYAIEIDL EPDTQAHVTT QSATRIQEMD ANFATQTQTI
     TLGANSYLEY IPHPIIPHKH SRFVQQTEVT IHPTATLIYS EVLMAGRKYY GTGELFHYDL
     FSSKFHAAHT DGTSLFTEKF IVEPARGNVS RLGAMGSFHV FGNLILLTPK THADRLFETI
     DPVFDMDEGI AWGASRLPND AGLLFKVLGM ESAPVRAAIR KIWEAARQEV TSASLPENFL
     WA