ID   URED2_METEP             Reviewed;         311 AA.
AC   A9W296;
DT   02-SEP-2008, integrated into UniProtKB/Swiss-Prot.
DT   05-FEB-2008, sequence version 1.
DT   03-AUG-2022, entry version 61.
DE   RecName: Full=Urease accessory protein UreD 2 {ECO:0000255|HAMAP-Rule:MF_01384};
GN   Name=ureD2 {ECO:0000255|HAMAP-Rule:MF_01384}; OrderedLocusNames=Mext_1301;
OS   Methylorubrum extorquens (strain PA1) (Methylobacterium extorquens).
OC   Bacteria; Proteobacteria; Alphaproteobacteria; Hyphomicrobiales;
OC   Methylobacteriaceae; Methylorubrum.
OX   NCBI_TaxID=419610;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=PA1;
RG   US DOE Joint Genome Institute;
RA   Copeland A., Lucas S., Lapidus A., Barry K., Glavina del Rio T., Dalin E.,
RA   Tice H., Pitluck S., Saunders E., Brettin T., Bruce D., Detter J.C.,
RA   Han C., Schmutz J., Larimer F., Land M., Hauser L., Kyrpides N., Kim E.,
RA   Marx C., Richardson P.;
RT   "Complete sequence of Methylobacterium extorquens PA1.";
RL   Submitted (DEC-2007) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Required for maturation of urease via the functional
CC       incorporation of the urease nickel metallocenter. {ECO:0000255|HAMAP-
CC       Rule:MF_01384}.
CC   -!- SUBUNIT: UreD, UreF and UreG form a complex that acts as a GTP-
CC       hydrolysis-dependent molecular chaperone, activating the urease
CC       apoprotein by helping to assemble the nickel containing metallocenter
CC       of UreC. The UreE protein probably delivers the nickel.
CC       {ECO:0000255|HAMAP-Rule:MF_01384}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_01384}.
CC   -!- SIMILARITY: Belongs to the UreD family. {ECO:0000255|HAMAP-
CC       Rule:MF_01384}.
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DR   EMBL; CP000908; ABY29702.1; -; Genomic_DNA.
DR   RefSeq; WP_012252935.1; NC_010172.1.
DR   AlphaFoldDB; A9W296; -.
DR   SMR; A9W296; -.
DR   STRING; 419610.Mext_1301; -.
DR   EnsemblBacteria; ABY29702; ABY29702; Mext_1301.
DR   KEGG; mex:Mext_1301; -.
DR   eggNOG; COG0829; Bacteria.
DR   HOGENOM; CLU_056339_1_0_5; -.
DR   OMA; IPFENAH; -.
DR   BioCyc; MEXT419610:MEXT_RS06555-MON; -.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0016151; F:nickel cation binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0006807; P:nitrogen compound metabolic process; IEA:InterPro.
DR   HAMAP; MF_01384; UreD; 1.
DR   InterPro; IPR002669; UreD.
DR   PANTHER; PTHR33643; PTHR33643; 1.
DR   Pfam; PF01774; UreD; 1.
PE   3: Inferred from homology;
KW   Chaperone; Cytoplasm; Nickel insertion.
FT   CHAIN           1..311
FT                   /note="Urease accessory protein UreD 2"
FT                   /id="PRO_0000346573"
SQ   SEQUENCE   311 AA;  34490 MW;  4B78908F2091D2FB CRC64;
     MTLHEPLGLI DAARELRGFQ AEPAQMRAGA PGKVGRLRLG FSLRDGRSVL HDLYRAAPLL
     VQQALYWDEA MPELPVCPII SVGGGILQGD RYTIDIAVGE GACAHVSTQG ANRIHCMDAN
     YASQHQTVTV AAGGYLEYLP DFTIPYRGSR FLSRTDLVVA ADATLLYGEM VLAGRKHHHV
     EERFGFDLLS MDVNLRRPGG HKLVAEKILI EKGDPTIAFA AVMRGFDAFA NILCVTPPET
     AARIKERFEP HFPIEAPRAL SGVSRLPNAA GLMLRAVGVE TYDVRHEVRR FWRIVREEAR
     DRSLPAEPYW R