ID   URED2_METRJ             Reviewed;         278 AA.
AC   B1M9D6;
DT   02-SEP-2008, integrated into UniProtKB/Swiss-Prot.
DT   29-APR-2008, sequence version 1.
DT   25-MAY-2022, entry version 55.
DE   RecName: Full=Urease accessory protein UreD 2 {ECO:0000255|HAMAP-Rule:MF_01384};
GN   Name=ureD2 {ECO:0000255|HAMAP-Rule:MF_01384};
GN   OrderedLocusNames=Mrad2831_6187;
OS   Methylobacterium radiotolerans (strain ATCC 27329 / DSM 1819 / JCM 2831 /
OS   NBRC 15690 / NCIMB 10815 / 0-1).
OG   Plasmid pMRAD01.
OC   Bacteria; Proteobacteria; Alphaproteobacteria; Hyphomicrobiales;
OC   Methylobacteriaceae; Methylobacterium.
OX   NCBI_TaxID=426355;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 27329 / DSM 1819 / JCM 2831 / NBRC 15690 / NCIMB 10815 / 0-1;
RG   US DOE Joint Genome Institute;
RA   Copeland A., Lucas S., Lapidus A., Glavina del Rio T., Dalin E., Tice H.,
RA   Bruce D., Goodwin L., Pitluck S., Kiss H., Brettin T., Detter J.C., Han C.,
RA   Kuske C.R., Schmutz J., Larimer F., Land M., Hauser L., Kyrpides N.,
RA   Mikhailova N., Marx C.J., Richardson P.;
RT   "Complete sequence of plasmid1 of Methylobacterium radiotolerans JCM
RT   2831.";
RL   Submitted (MAR-2008) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Required for maturation of urease via the functional
CC       incorporation of the urease nickel metallocenter. {ECO:0000255|HAMAP-
CC       Rule:MF_01384}.
CC   -!- SUBUNIT: UreD, UreF and UreG form a complex that acts as a GTP-
CC       hydrolysis-dependent molecular chaperone, activating the urease
CC       apoprotein by helping to assemble the nickel containing metallocenter
CC       of UreC. The UreE protein probably delivers the nickel.
CC       {ECO:0000255|HAMAP-Rule:MF_01384}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_01384}.
CC   -!- SIMILARITY: Belongs to the UreD family. {ECO:0000255|HAMAP-
CC       Rule:MF_01384}.
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DR   EMBL; CP001002; ACB28111.1; -; Genomic_DNA.
DR   RefSeq; WP_012329897.1; NC_010510.1.
DR   AlphaFoldDB; B1M9D6; -.
DR   SMR; B1M9D6; -.
DR   STRING; 426355.Mrad2831_6187; -.
DR   PRIDE; B1M9D6; -.
DR   EnsemblBacteria; ACB28111; ACB28111; Mrad2831_6187.
DR   KEGG; mrd:Mrad2831_6187; -.
DR   PATRIC; fig|426355.14.peg.6261; -.
DR   eggNOG; COG0829; Bacteria.
DR   HOGENOM; CLU_056339_1_1_5; -.
DR   OMA; PYPFHIT; -.
DR   OrthoDB; 1764668at2; -.
DR   Proteomes; UP000006589; Plasmid pMRAD01.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0016151; F:nickel cation binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0006807; P:nitrogen compound metabolic process; IEA:InterPro.
DR   HAMAP; MF_01384; UreD; 1.
DR   InterPro; IPR002669; UreD.
DR   PANTHER; PTHR33643; PTHR33643; 1.
DR   Pfam; PF01774; UreD; 1.
PE   3: Inferred from homology;
KW   Chaperone; Cytoplasm; Nickel insertion; Plasmid; Reference proteome.
FT   CHAIN           1..278
FT                   /note="Urease accessory protein UreD 2"
FT                   /id="PRO_0000346579"
SQ   SEQUENCE   278 AA;  28945 MW;  B918639CE7123BF0 CRC64;
     MPDDIQTGRR ATARLGFVRG GGTSVLADQH VPYPFHITKP FRLYPQRPEL ITLYLQSASG
     GLYRGDRLGL DIAMGPGSAA HVTTQAATVV HRSADRPARQ DTRIRVAADA FLHCVPDPLI
     LFPGAALSAT TQITLEPGAR AVVSESIACH DPEGRGRPFD RVELGLGIET AAGAVLVRER
     ARIAGAEFHA PDSPLGPWRA YGAMVILGPA PCLPDPGDVQ AAADRTGCRA GLSPLPNAAG
     LGLRLLAPDG GTLAAGLEAA AGRAFAALTG LAPARRRK