ID   URED2_SACEN             Reviewed;         283 AA.
AC   A4FCP0;
DT   02-SEP-2008, integrated into UniProtKB/Swiss-Prot.
DT   02-SEP-2008, sequence version 2.
DT   25-MAY-2022, entry version 60.
DE   RecName: Full=Urease accessory protein UreD 2 {ECO:0000255|HAMAP-Rule:MF_01384};
GN   Name=ureD2 {ECO:0000255|HAMAP-Rule:MF_01384}; OrderedLocusNames=SACE_2523;
OS   Saccharopolyspora erythraea (strain ATCC 11635 / DSM 40517 / JCM 4748 /
OS   NBRC 13426 / NCIMB 8594 / NRRL 2338).
OC   Bacteria; Actinobacteria; Pseudonocardiales; Pseudonocardiaceae;
OC   Saccharopolyspora.
OX   NCBI_TaxID=405948;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 11635 / DSM 40517 / JCM 4748 / NBRC 13426 / NCIMB 8594 / NRRL
RC   2338;
RX   PubMed=17369815; DOI=10.1038/nbt1297;
RA   Oliynyk M., Samborskyy M., Lester J.B., Mironenko T., Scott N., Dickens S.,
RA   Haydock S.F., Leadlay P.F.;
RT   "Complete genome sequence of the erythromycin-producing bacterium
RT   Saccharopolyspora erythraea NRRL23338.";
RL   Nat. Biotechnol. 25:447-453(2007).
CC   -!- FUNCTION: Required for maturation of urease via the functional
CC       incorporation of the urease nickel metallocenter. {ECO:0000255|HAMAP-
CC       Rule:MF_01384}.
CC   -!- SUBUNIT: UreD, UreF and UreG form a complex that acts as a GTP-
CC       hydrolysis-dependent molecular chaperone, activating the urease
CC       apoprotein by helping to assemble the nickel containing metallocenter
CC       of UreC. The UreE protein probably delivers the nickel.
CC       {ECO:0000255|HAMAP-Rule:MF_01384}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_01384}.
CC   -!- SIMILARITY: Belongs to the UreD family. {ECO:0000255|HAMAP-
CC       Rule:MF_01384}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=CAM01815.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR   EMBL; AM420293; CAM01815.1; ALT_INIT; Genomic_DNA.
DR   AlphaFoldDB; A4FCP0; -.
DR   SMR; A4FCP0; -.
DR   STRING; 405948.SACE_2523; -.
DR   EnsemblBacteria; CAM01815; CAM01815; SACE_2523.
DR   KEGG; sen:SACE_2523; -.
DR   eggNOG; COG0829; Bacteria.
DR   HOGENOM; CLU_055097_4_0_11; -.
DR   Proteomes; UP000006728; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0016151; F:nickel cation binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0006807; P:nitrogen compound metabolic process; IEA:InterPro.
DR   HAMAP; MF_01384; UreD; 1.
DR   InterPro; IPR002669; UreD.
DR   Pfam; PF01774; UreD; 1.
PE   3: Inferred from homology;
KW   Chaperone; Cytoplasm; Nickel insertion; Reference proteome.
FT   CHAIN           1..283
FT                   /note="Urease accessory protein UreD 2"
FT                   /id="PRO_0000346592"
FT   REGION          1..30
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   283 AA;  29757 MW;  04B3DC5FAC90646B CRC64;
     MGRRAPDRLD RGVTTTSPRT QAPPQAGRGV HATARIRATS HDGVTVLPLL RSDGPFHLRQ
     LRNHGSQARV CVVSAMSAPL GGDRLAIDVS VEAGAQLEIT TAAATLALRG ATTDHATYDV
     TLTVGEQATL YWLPQPLIST RGSNLRQTYT VDLAPTARLI LREELILGRA HEPPGDLSSH
     LTVHRDGRPL LAQHTTFGST APGWDGPAVL GEHRATGQIL IVDPAFANAP PATRLLGDEP
     ANGEGIVAPL AGPAVLATAL APTATPLRHL LDDAVRPRTP CST