ID   URED2_STRGG             Reviewed;         293 AA.
AC   B1VSW8;
DT   02-SEP-2008, integrated into UniProtKB/Swiss-Prot.
DT   02-SEP-2008, sequence version 2.
DT   25-MAY-2022, entry version 64.
DE   RecName: Full=Urease accessory protein UreD 2 {ECO:0000255|HAMAP-Rule:MF_01384};
GN   Name=ureD2 {ECO:0000255|HAMAP-Rule:MF_01384}; OrderedLocusNames=SGR_843;
OS   Streptomyces griseus subsp. griseus (strain JCM 4626 / NBRC 13350).
OC   Bacteria; Actinobacteria; Streptomycetales; Streptomycetaceae;
OC   Streptomyces.
OX   NCBI_TaxID=455632;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=JCM 4626 / NBRC 13350;
RX   PubMed=18375553; DOI=10.1128/jb.00204-08;
RA   Ohnishi Y., Ishikawa J., Hara H., Suzuki H., Ikenoya M., Ikeda H.,
RA   Yamashita A., Hattori M., Horinouchi S.;
RT   "Genome sequence of the streptomycin-producing microorganism Streptomyces
RT   griseus IFO 13350.";
RL   J. Bacteriol. 190:4050-4060(2008).
CC   -!- FUNCTION: Required for maturation of urease via the functional
CC       incorporation of the urease nickel metallocenter. {ECO:0000255|HAMAP-
CC       Rule:MF_01384}.
CC   -!- SUBUNIT: UreD, UreF and UreG form a complex that acts as a GTP-
CC       hydrolysis-dependent molecular chaperone, activating the urease
CC       apoprotein by helping to assemble the nickel containing metallocenter
CC       of UreC. The UreE protein probably delivers the nickel.
CC       {ECO:0000255|HAMAP-Rule:MF_01384}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_01384}.
CC   -!- SIMILARITY: Belongs to the UreD family. {ECO:0000255|HAMAP-
CC       Rule:MF_01384}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=BAG17672.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR   EMBL; AP009493; BAG17672.1; ALT_INIT; Genomic_DNA.
DR   AlphaFoldDB; B1VSW8; -.
DR   SMR; B1VSW8; -.
DR   STRING; 455632.SGR_843; -.
DR   PRIDE; B1VSW8; -.
DR   EnsemblBacteria; BAG17672; BAG17672; SGR_843.
DR   KEGG; sgr:SGR_843; -.
DR   PATRIC; fig|455632.4.peg.834; -.
DR   eggNOG; COG0829; Bacteria.
DR   HOGENOM; CLU_056339_1_0_11; -.
DR   Proteomes; UP000001685; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0016151; F:nickel cation binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0006807; P:nitrogen compound metabolic process; IEA:InterPro.
DR   HAMAP; MF_01384; UreD; 1.
DR   InterPro; IPR002669; UreD.
DR   PANTHER; PTHR33643; PTHR33643; 1.
DR   Pfam; PF01774; UreD; 1.
PE   3: Inferred from homology;
KW   Chaperone; Cytoplasm; Nickel insertion.
FT   CHAIN           1..293
FT                   /note="Urease accessory protein UreD 2"
FT                   /id="PRO_0000346608"
SQ   SEQUENCE   293 AA;  31554 MW;  85D7E979BD787AE5 CRC64;
     MAALASVPDT LAPGSPAKVG ILDLAFAVRG GRTELVERYQ KTPLQIMRPL WIDPEQPGMS
     YVYIMATGAG VAQADRYRMD FRCGPDTQVH LTTQAATKIF RMEHDYASQR VHLSAEAGSY
     VEYLPDPLIP FKGSRFYQRT EVTVAPGATV VVADTLTAGR LARGERHAYR VLATDLHISR
     PDGTLLAIDT LRLVPGRRGG GVLGPAVFAG HDLVASLFAV TDRVPATVLA DALHDALAGL
     GLLHGVSVLP RDCGAWVRVL DDSPIRIAGA QEAVRQAVRR LLTGRPAPDL RKP