ID   URED2_SYNJA             Reviewed;         267 AA.
AC   Q2JWA7;
DT   10-JUN-2008, integrated into UniProtKB/Swiss-Prot.
DT   07-MAR-2006, sequence version 1.
DT   25-MAY-2022, entry version 70.
DE   RecName: Full=Urease accessory protein UreD 2 {ECO:0000255|HAMAP-Rule:MF_01384};
GN   Name=ureD2 {ECO:0000255|HAMAP-Rule:MF_01384}; OrderedLocusNames=CYA_0753;
OS   Synechococcus sp. (strain JA-3-3Ab) (Cyanobacteria bacterium Yellowstone
OS   A-Prime).
OC   Bacteria; Cyanobacteria; Synechococcales; Synechococcaceae; Synechococcus;
OC   unclassified Synechococcus.
OX   NCBI_TaxID=321327;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=JA-3-3Ab;
RX   PubMed=18059494; DOI=10.1038/ismej.2007.46;
RA   Bhaya D., Grossman A.R., Steunou A.-S., Khuri N., Cohan F.M., Hamamura N.,
RA   Melendrez M.C., Bateson M.M., Ward D.M., Heidelberg J.F.;
RT   "Population level functional diversity in a microbial community revealed by
RT   comparative genomic and metagenomic analyses.";
RL   ISME J. 1:703-713(2007).
CC   -!- FUNCTION: Required for maturation of urease via the functional
CC       incorporation of the urease nickel metallocenter. {ECO:0000255|HAMAP-
CC       Rule:MF_01384}.
CC   -!- SUBUNIT: UreD, UreF and UreG form a complex that acts as a GTP-
CC       hydrolysis-dependent molecular chaperone, activating the urease
CC       apoprotein by helping to assemble the nickel containing metallocenter
CC       of UreC. The UreE protein probably delivers the nickel.
CC       {ECO:0000255|HAMAP-Rule:MF_01384}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_01384}.
CC   -!- SIMILARITY: Belongs to the UreD family. {ECO:0000255|HAMAP-
CC       Rule:MF_01384}.
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DR   EMBL; CP000239; ABC98961.1; -; Genomic_DNA.
DR   RefSeq; WP_011429645.1; NC_007775.1.
DR   AlphaFoldDB; Q2JWA7; -.
DR   SMR; Q2JWA7; -.
DR   STRING; 321327.CYA_0753; -.
DR   EnsemblBacteria; ABC98961; ABC98961; CYA_0753.
DR   KEGG; cya:CYA_0753; -.
DR   eggNOG; COG0829; Bacteria.
DR   HOGENOM; CLU_1069312_0_0_3; -.
DR   OMA; WEYSQAP; -.
DR   OrthoDB; 1764668at2; -.
DR   Proteomes; UP000008818; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0016151; F:nickel cation binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0006807; P:nitrogen compound metabolic process; IEA:InterPro.
DR   HAMAP; MF_01384; UreD; 1.
DR   InterPro; IPR002669; UreD.
DR   PANTHER; PTHR33643; PTHR33643; 1.
DR   Pfam; PF01774; UreD; 1.
PE   3: Inferred from homology;
KW   Chaperone; Cytoplasm; Nickel insertion.
FT   CHAIN           1..267
FT                   /note="Urease accessory protein UreD 2"
FT                   /id="PRO_0000340527"
SQ   SEQUENCE   267 AA;  29605 MW;  E245EA80A8E2DD00 CRC64;
     MTFGKALLKI SRQGEHARIW EYSQAPLQWL GSPGEPPLYY LRNPNGGLLG GDRHHIAIEL
     GAGAGLAIRT QGATRLHPGL IRQQAKVKLA PTSQLIWIPH PTIPGAGADF RQQVQIELDP
     SARLAYAEIW TAGRLAMGEC WQFRRLSSSL RVWVAAGSPS ASRQKKLWLQ EHIDLRFPHQ
     HVSTASVLGS HLCWGSLYLL GDWPEPTWPT VHVSGTESPH WLVKSPDPVC QGWILRQVGP
     QAEAIWQQFG QVVQQLAAAQ RSSSQGW