ID   URED3_METEP             Reviewed;         298 AA.
AC   A9W6X7;
DT   02-SEP-2008, integrated into UniProtKB/Swiss-Prot.
DT   02-SEP-2008, sequence version 2.
DT   25-MAY-2022, entry version 57.
DE   RecName: Full=Urease accessory protein UreD 3 {ECO:0000255|HAMAP-Rule:MF_01384};
GN   Name=ureD3 {ECO:0000255|HAMAP-Rule:MF_01384}; OrderedLocusNames=Mext_3020;
OS   Methylorubrum extorquens (strain PA1) (Methylobacterium extorquens).
OC   Bacteria; Proteobacteria; Alphaproteobacteria; Hyphomicrobiales;
OC   Methylobacteriaceae; Methylorubrum.
OX   NCBI_TaxID=419610;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=PA1;
RG   US DOE Joint Genome Institute;
RA   Copeland A., Lucas S., Lapidus A., Barry K., Glavina del Rio T., Dalin E.,
RA   Tice H., Pitluck S., Saunders E., Brettin T., Bruce D., Detter J.C.,
RA   Han C., Schmutz J., Larimer F., Land M., Hauser L., Kyrpides N., Kim E.,
RA   Marx C., Richardson P.;
RT   "Complete sequence of Methylobacterium extorquens PA1.";
RL   Submitted (DEC-2007) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Required for maturation of urease via the functional
CC       incorporation of the urease nickel metallocenter. {ECO:0000255|HAMAP-
CC       Rule:MF_01384}.
CC   -!- SUBUNIT: UreD, UreF and UreG form a complex that acts as a GTP-
CC       hydrolysis-dependent molecular chaperone, activating the urease
CC       apoprotein by helping to assemble the nickel containing metallocenter
CC       of UreC. The UreE protein probably delivers the nickel.
CC       {ECO:0000255|HAMAP-Rule:MF_01384}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_01384}.
CC   -!- SIMILARITY: Belongs to the UreD family. {ECO:0000255|HAMAP-
CC       Rule:MF_01384}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=ABY31409.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR   EMBL; CP000908; ABY31409.1; ALT_INIT; Genomic_DNA.
DR   AlphaFoldDB; A9W6X7; -.
DR   SMR; A9W6X7; -.
DR   STRING; 419610.Mext_3020; -.
DR   EnsemblBacteria; ABY31409; ABY31409; Mext_3020.
DR   KEGG; mex:Mext_3020; -.
DR   eggNOG; COG0829; Bacteria.
DR   HOGENOM; CLU_056339_2_0_5; -.
DR   OMA; MARFCAQ; -.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0016151; F:nickel cation binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0006807; P:nitrogen compound metabolic process; IEA:InterPro.
DR   HAMAP; MF_01384; UreD; 1.
DR   InterPro; IPR002669; UreD.
DR   PANTHER; PTHR33643; PTHR33643; 1.
DR   Pfam; PF01774; UreD; 1.
PE   3: Inferred from homology;
KW   Chaperone; Cytoplasm; Nickel insertion.
FT   CHAIN           1..298
FT                   /note="Urease accessory protein UreD 3"
FT                   /id="PRO_0000346574"
FT   REGION          1..30
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   298 AA;  31601 MW;  A6172E3123FA2987 CRC64;
     MADEAGTRSA GGRPIPAAEP LRPALSRQRS QGAVHLRVAP AGTAADAPTR IVDLAESGPL
     RLRCPRQGAE RMLEGVLVNT GGGIACGDVF TVSVTVEPGG ACVLTTTAAE KIYRSDGPCA
     EIVNRASVGA GGRLDWLPQE TILFDRARLV RRFEADLAPD ASLLVAEIAV LGRAARGESL
     EQALFEDRWR IRRDGRLVYA DSLRLDGAVT ALMNRRAIGG GARALATILD LSLRAEGRLD
     EARALLDALP AQVEAGASAW NGHLAVRMLA PTVAPLRDAA ARFLAAWRGQ PMPRVWQT