ID   URED_ACIAC              Reviewed;         276 AA.
AC   A1TL40;
DT   10-JUN-2008, integrated into UniProtKB/Swiss-Prot.
DT   06-FEB-2007, sequence version 1.
DT   25-MAY-2022, entry version 69.
DE   RecName: Full=Urease accessory protein UreD {ECO:0000255|HAMAP-Rule:MF_01384};
GN   Name=ureD {ECO:0000255|HAMAP-Rule:MF_01384}; OrderedLocusNames=Aave_1082;
OS   Acidovorax citrulli (strain AAC00-1) (Acidovorax avenae subsp. citrulli).
OC   Bacteria; Proteobacteria; Betaproteobacteria; Burkholderiales;
OC   Comamonadaceae; Acidovorax.
OX   NCBI_TaxID=397945;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=AAC00-1;
RA   Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C.,
RA   Glavina del Rio T., Dalin E., Tice H., Pitluck S., Kiss H., Brettin T.,
RA   Bruce D., Han C., Tapia R., Gilna P., Schmutz J., Larimer F., Land M.,
RA   Hauser L., Kyrpides N., Kim E., Stahl D., Richardson P.;
RT   "Complete sequence of Acidovorax avenae subsp. citrulli AAC00-1.";
RL   Submitted (DEC-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Required for maturation of urease via the functional
CC       incorporation of the urease nickel metallocenter. {ECO:0000255|HAMAP-
CC       Rule:MF_01384}.
CC   -!- SUBUNIT: UreD, UreF and UreG form a complex that acts as a GTP-
CC       hydrolysis-dependent molecular chaperone, activating the urease
CC       apoprotein by helping to assemble the nickel containing metallocenter
CC       of UreC. The UreE protein probably delivers the nickel.
CC       {ECO:0000255|HAMAP-Rule:MF_01384}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_01384}.
CC   -!- SIMILARITY: Belongs to the UreD family. {ECO:0000255|HAMAP-
CC       Rule:MF_01384}.
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DR   EMBL; CP000512; ABM31678.1; -; Genomic_DNA.
DR   RefSeq; WP_011794234.1; NC_008752.1.
DR   AlphaFoldDB; A1TL40; -.
DR   SMR; A1TL40; -.
DR   STRING; 397945.Aave_1082; -.
DR   EnsemblBacteria; ABM31678; ABM31678; Aave_1082.
DR   KEGG; aav:Aave_1082; -.
DR   eggNOG; COG0829; Bacteria.
DR   HOGENOM; CLU_056339_0_0_4; -.
DR   OMA; CHHVLVH; -.
DR   OrthoDB; 1764668at2; -.
DR   Proteomes; UP000002596; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0016151; F:nickel cation binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0006807; P:nitrogen compound metabolic process; IEA:InterPro.
DR   HAMAP; MF_01384; UreD; 1.
DR   InterPro; IPR002669; UreD.
DR   PANTHER; PTHR33643; PTHR33643; 1.
DR   Pfam; PF01774; UreD; 1.
PE   3: Inferred from homology;
KW   Chaperone; Cytoplasm; Nickel insertion; Reference proteome.
FT   CHAIN           1..276
FT                   /note="Urease accessory protein UreD"
FT                   /id="PRO_0000340398"
SQ   SEQUENCE   276 AA;  29713 MW;  B7A7BEA589699F62 CRC64;
     MTWHARLQLD YRREGPRTVA GFLHDGPLRI LQSLYPEGGG ICHNVLVHPP GGLVGGDTLD
     IAATVAPGAH GLVTTPGATR FYRSTGAPAL QRTQATLAAG ARLEWLPLEA LCYSACQAEN
     RLTLSLSPGA ECIAWDVTAL GLPHSGQPFA TGRFTQHIEV PGIWLERGTI DAADGLLMDG
     RLGLAGHRCL ASVFFVAGEA LPRERREAAL DAARAVIDAH ALRETAGATS PHPQVVVVRV
     LAPVVEPAME LLRRAWGAWR EHLWGLQPRQ PRIWAM