URED_ACIBC
ID URED_ACIBC Reviewed; 291 AA.
AC B2HVR7;
DT 02-SEP-2008, integrated into UniProtKB/Swiss-Prot.
DT 02-SEP-2008, sequence version 2.
DT 25-MAY-2022, entry version 54.
DE RecName: Full=Urease accessory protein UreD {ECO:0000255|HAMAP-Rule:MF_01384};
GN Name=ureD {ECO:0000255|HAMAP-Rule:MF_01384}; OrderedLocusNames=ACICU_00971;
OS Acinetobacter baumannii (strain ACICU).
OC Bacteria; Proteobacteria; Gammaproteobacteria; Moraxellales; Moraxellaceae;
OC Acinetobacter; Acinetobacter calcoaceticus/baumannii complex.
OX NCBI_TaxID=405416;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ACICU;
RX PubMed=18411315; DOI=10.1128/aac.01643-07;
RA Iacono M., Villa L., Fortini D., Bordoni R., Imperi F., Bonnal R.J.,
RA Sicheritz-Ponten T., De Bellis G., Visca P., Cassone A., Carattoli A.;
RT "Whole-genome pyrosequencing of an epidemic multidrug-resistant
RT Acinetobacter baumannii strain belonging to the European clone II group.";
RL Antimicrob. Agents Chemother. 52:2616-2625(2008).
CC -!- FUNCTION: Required for maturation of urease via the functional
CC incorporation of the urease nickel metallocenter. {ECO:0000255|HAMAP-
CC Rule:MF_01384}.
CC -!- SUBUNIT: UreD, UreF and UreG form a complex that acts as a GTP-
CC hydrolysis-dependent molecular chaperone, activating the urease
CC apoprotein by helping to assemble the nickel containing metallocenter
CC of UreC. The UreE protein probably delivers the nickel.
CC {ECO:0000255|HAMAP-Rule:MF_01384}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_01384}.
CC -!- SIMILARITY: Belongs to the UreD family. {ECO:0000255|HAMAP-
CC Rule:MF_01384}.
CC -!- SEQUENCE CAUTION:
CC Sequence=ACC56283.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR EMBL; CP000863; ACC56283.1; ALT_INIT; Genomic_DNA.
DR RefSeq; WP_002017326.1; NC_010611.1.
DR AlphaFoldDB; B2HVR7; -.
DR SMR; B2HVR7; -.
DR KEGG; abc:ACICU_00971; -.
DR HOGENOM; CLU_056339_0_0_6; -.
DR Proteomes; UP000008839; Chromosome.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0016151; F:nickel cation binding; IEA:UniProtKB-UniRule.
DR GO; GO:0006807; P:nitrogen compound metabolic process; IEA:InterPro.
DR HAMAP; MF_01384; UreD; 1.
DR InterPro; IPR002669; UreD.
DR PANTHER; PTHR33643; PTHR33643; 1.
DR Pfam; PF01774; UreD; 1.
PE 3: Inferred from homology;
KW Chaperone; Cytoplasm; Nickel insertion.
FT CHAIN 1..291
FT /note="Urease accessory protein UreD"
FT /id="PRO_0000346548"
SQ SEQUENCE 291 AA; 33897 MW; AED66EC45F286DC3 CRC64;
MNRIQQTFQT SSAPFWYAQL ELGFCYENSR TIMSHRKHYG PVRVQKMLWP EKTGVCHAII
VHPPAGIAGG DHLTFQIETE RQAHAVITTP GAGKWYRTNG KHAFQHIYLN VKDDSILEWM
PQETMLFDGA LAHSETDIHL EQTASFIGWD MLVLGRQARA ENFVQGSYHN QFKLWRKNKL
LVADTLYFEG GDRWLSSCLG MNNQAVMASF WAVPPEKFRS SFYLEQHIEL IRELIMRMDV
PVTLTLLEDV LCARFLGNDV RRCHDAFAAI RAKLRRYWFD LDEEFPRIWK T