ID   URED_ACTNA              Reviewed;         271 AA.
AC   Q9Z364;
DT   30-MAY-2000, integrated into UniProtKB/Swiss-Prot.
DT   01-MAY-1999, sequence version 1.
DT   25-MAY-2022, entry version 49.
DE   RecName: Full=Urease accessory protein UreD {ECO:0000255|HAMAP-Rule:MF_01384};
GN   Name=ureD {ECO:0000255|HAMAP-Rule:MF_01384};
OS   Actinomyces naeslundii.
OC   Bacteria; Actinobacteria; Actinomycetales; Actinomycetaceae; Actinomyces.
OX   NCBI_TaxID=1655;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=WVU45;
RX   PubMed=9916052; DOI=10.1128/iai.67.2.504-512.1999;
RA   Morou-Bermudez E., Burne R.A.;
RT   "Genetic and physiologic characterization of urease of Actinomyces
RT   naeslundii.";
RL   Infect. Immun. 67:504-512(1999).
CC   -!- FUNCTION: Required for maturation of urease via the functional
CC       incorporation of the urease nickel metallocenter. {ECO:0000255|HAMAP-
CC       Rule:MF_01384}.
CC   -!- SUBUNIT: UreD, UreF and UreG form a complex that acts as a GTP-
CC       hydrolysis-dependent molecular chaperone, activating the urease
CC       apoprotein by helping to assemble the nickel containing metallocenter
CC       of UreC. The UreE protein probably delivers the nickel.
CC       {ECO:0000255|HAMAP-Rule:MF_01384}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_01384}.
CC   -!- SIMILARITY: Belongs to the UreD family. {ECO:0000255|HAMAP-
CC       Rule:MF_01384}.
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DR   EMBL; AF056321; AAD13736.1; -; Genomic_DNA.
DR   EMBL; AF048781; AAD13726.1; -; Genomic_DNA.
DR   RefSeq; WP_003781997.1; NZ_MSRU01000006.1.
DR   AlphaFoldDB; Q9Z364; -.
DR   SMR; Q9Z364; -.
DR   STRING; 1655.BKH10_09530; -.
DR   GeneID; 64257300; -.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0016151; F:nickel cation binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0006807; P:nitrogen compound metabolic process; IEA:InterPro.
DR   HAMAP; MF_01384; UreD; 1.
DR   InterPro; IPR002669; UreD.
DR   PANTHER; PTHR33643; PTHR33643; 1.
DR   Pfam; PF01774; UreD; 1.
PE   3: Inferred from homology;
KW   Chaperone; Cytoplasm; Nickel insertion.
FT   CHAIN           1..271
FT                   /note="Urease accessory protein UreD"
FT                   /id="PRO_0000067601"
SQ   SEQUENCE   271 AA;  29247 MW;  0042A71CC3F006B4 CRC64;
     MSTTGELYLR IAQDGDRSIA VDQYHRGALR VFRPLYLDGT GQVAYYVVNP GGGYLDGDSY
     LTEVEVLQGA SAVLTTQAAT KIYRTPTRPV RQDTRASLAP GAVLELVPDQ VIAYRGASYR
     QTTLVEMDPT ATFMSLEVLT PGWAPDGSAF GYDCVRMRTE IRVGGRCAVV DNLRLVPGEA
     GMAGLGALEG HSHLASFTAL DARIDAALVT EIGELLEVDG VRGAVTRVPG PGLIARALGD
     DTTRLTALML DISELLRDRW FGAPRLDLRK Y