ID   URED_ACTP2              Reviewed;         270 AA.
AC   A3N2Q9;
DT   10-JUN-2008, integrated into UniProtKB/Swiss-Prot.
DT   03-APR-2007, sequence version 1.
DT   03-AUG-2022, entry version 79.
DE   RecName: Full=Urease accessory protein UreD {ECO:0000255|HAMAP-Rule:MF_01384};
GN   Name=ureD {ECO:0000255|HAMAP-Rule:MF_01384}; OrderedLocusNames=APL_1611;
OS   Actinobacillus pleuropneumoniae serotype 5b (strain L20).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Pasteurellales;
OC   Pasteurellaceae; Actinobacillus.
OX   NCBI_TaxID=416269;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=L20;
RX   PubMed=18065534; DOI=10.1128/jb.01845-07;
RA   Foote S.J., Bosse J.T., Bouevitch A.B., Langford P.R., Young N.M.,
RA   Nash J.H.E.;
RT   "The complete genome sequence of Actinobacillus pleuropneumoniae L20
RT   (serotype 5b).";
RL   J. Bacteriol. 190:1495-1496(2008).
CC   -!- FUNCTION: Required for maturation of urease via the functional
CC       incorporation of the urease nickel metallocenter. {ECO:0000255|HAMAP-
CC       Rule:MF_01384}.
CC   -!- SUBUNIT: UreD, UreF and UreG form a complex that acts as a GTP-
CC       hydrolysis-dependent molecular chaperone, activating the urease
CC       apoprotein by helping to assemble the nickel containing metallocenter
CC       of UreC. The UreE protein probably delivers the nickel.
CC       {ECO:0000255|HAMAP-Rule:MF_01384}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_01384}.
CC   -!- SIMILARITY: Belongs to the UreD family. {ECO:0000255|HAMAP-
CC       Rule:MF_01384}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; CP000569; ABN74695.1; -; Genomic_DNA.
DR   RefSeq; WP_009874589.1; NC_009053.1.
DR   AlphaFoldDB; A3N2Q9; -.
DR   SMR; A3N2Q9; -.
DR   STRING; 416269.APL_1611; -.
DR   EnsemblBacteria; ABN74695; ABN74695; APL_1611.
DR   KEGG; apl:APL_1611; -.
DR   PATRIC; fig|416269.6.peg.1677; -.
DR   eggNOG; COG0829; Bacteria.
DR   HOGENOM; CLU_056339_6_0_6; -.
DR   OMA; IPFENAH; -.
DR   Proteomes; UP000001432; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0016151; F:nickel cation binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0006807; P:nitrogen compound metabolic process; IEA:InterPro.
DR   HAMAP; MF_01384; UreD; 1.
DR   InterPro; IPR002669; UreD.
DR   PANTHER; PTHR33643; PTHR33643; 1.
DR   Pfam; PF01774; UreD; 1.
PE   3: Inferred from homology;
KW   Chaperone; Cytoplasm; Nickel insertion; Reference proteome.
FT   CHAIN           1..270
FT                   /note="Urease accessory protein UreD"
FT                   /id="PRO_0000340402"
SQ   SEQUENCE   270 AA;  30142 MW;  9174A9D7B06F7AC5 CRC64;
     MQSKLLLSTK LTSQGKTQLD QYFVSPPFKV MTLPAYDDAW QNGLNAMQMS SSPGLLAGDL
     LDIEISLADN TALSLNTQAF TRVQSMNEGD YATQKTCIKL GKNSRLFYLP HPLVLHKDSG
     FKQTTEIEMS EQSELIYGEI VAIGRVLNGE RFAFRHFASY LRISYQNQPL VTDRIQWLPA
     KMALTSLSQM EDFSHQGSLT YVNLAKNAVE IKAMVSELQA LAAEQKNMLI GVSQLNEGGL
     MVRVLAHRAD IIQHLFERIG QVLKAQSNIV