ID   URED_ACTP7              Reviewed;         270 AA.
AC   B3H2K8;
DT   14-APR-2009, integrated into UniProtKB/Swiss-Prot.
DT   22-JUL-2008, sequence version 1.
DT   03-AUG-2022, entry version 58.
DE   RecName: Full=Urease accessory protein UreD {ECO:0000255|HAMAP-Rule:MF_01384};
GN   Name=ureD {ECO:0000255|HAMAP-Rule:MF_01384}; OrderedLocusNames=APP7_1673;
OS   Actinobacillus pleuropneumoniae serotype 7 (strain AP76).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Pasteurellales;
OC   Pasteurellaceae; Actinobacillus.
OX   NCBI_TaxID=537457;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=AP76;
RA   Linke B., Buettner F., Martinez-Arias R., Goesmann A., Baltes N.,
RA   Tegetmeyer H., Singh M., Gerlach G.F.;
RT   "Genome and proteome analysis of A. pleuropneumoniae serotype 7.";
RL   Submitted (JUN-2008) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Required for maturation of urease via the functional
CC       incorporation of the urease nickel metallocenter. {ECO:0000255|HAMAP-
CC       Rule:MF_01384}.
CC   -!- SUBUNIT: UreD, UreF and UreG form a complex that acts as a GTP-
CC       hydrolysis-dependent molecular chaperone, activating the urease
CC       apoprotein by helping to assemble the nickel containing metallocenter
CC       of UreC. The UreE protein probably delivers the nickel.
CC       {ECO:0000255|HAMAP-Rule:MF_01384}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_01384}.
CC   -!- SIMILARITY: Belongs to the UreD family. {ECO:0000255|HAMAP-
CC       Rule:MF_01384}.
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DR   EMBL; CP001091; ACE62325.1; -; Genomic_DNA.
DR   RefSeq; WP_005598991.1; NC_010939.1.
DR   AlphaFoldDB; B3H2K8; -.
DR   SMR; B3H2K8; -.
DR   EnsemblBacteria; ACE62325; ACE62325; APP7_1673.
DR   GeneID; 66258365; -.
DR   KEGG; apa:APP7_1673; -.
DR   HOGENOM; CLU_056339_6_0_6; -.
DR   OMA; IPFENAH; -.
DR   BioCyc; APLE537457:APP7_RS08680-MON; -.
DR   Proteomes; UP000001226; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0016151; F:nickel cation binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0006807; P:nitrogen compound metabolic process; IEA:InterPro.
DR   HAMAP; MF_01384; UreD; 1.
DR   InterPro; IPR002669; UreD.
DR   PANTHER; PTHR33643; PTHR33643; 1.
DR   Pfam; PF01774; UreD; 1.
PE   3: Inferred from homology;
KW   Chaperone; Cytoplasm; Nickel insertion.
FT   CHAIN           1..270
FT                   /note="Urease accessory protein UreD"
FT                   /id="PRO_1000145087"
SQ   SEQUENCE   270 AA;  30215 MW;  DE8C7F51D256B4B6 CRC64;
     MQSKLLLSTK LTSQGKTQLD QYFVSPPFKV MTLPAYDDAW QNGLNAMQMS SSPGLLASDL
     LDIEISLADD TALSLNTQAF TRVQSMNEGD YATQKTCIKL GKNSRLFYLP HPLVLHKDSS
     FKQTTEIEMS EQSELIYGEI VAIGRVLNGE RFAFRHFASY LRISYQNRPI IADRIQWLPA
     KMALTSLSQM EDFSHQGSLT YVNLAKNAVE IKAMVSELQA LAAEQKNMLI GVSQLNEGGL
     MVRVLAHRAD IIQHLFERIG QVLKAQSNIV