ID   URED_ACTPL              Reviewed;         270 AA.
AC   O54425;
DT   15-DEC-1998, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-1998, sequence version 1.
DT   25-MAY-2022, entry version 53.
DE   RecName: Full=Urease accessory protein UreD {ECO:0000255|HAMAP-Rule:MF_01384};
GN   Name=ureD {ECO:0000255|HAMAP-Rule:MF_01384};
OS   Actinobacillus pleuropneumoniae (Haemophilus pleuropneumoniae).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Pasteurellales;
OC   Pasteurellaceae; Actinobacillus.
OX   NCBI_TaxID=715;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=CM5 / Serotype 1;
RX   PubMed=9353010; DOI=10.1128/iai.65.11.4389-4394.1997;
RA   Bosse J.T., Macinnes J.I.;
RT   "Genetic and biochemical analyses of Actinobacillus pleuropneumoniae
RT   urease.";
RL   Infect. Immun. 65:4389-4394(1997).
CC   -!- FUNCTION: Required for maturation of urease via the functional
CC       incorporation of the urease nickel metallocenter. {ECO:0000255|HAMAP-
CC       Rule:MF_01384}.
CC   -!- SUBUNIT: UreD, UreF and UreG form a complex that acts as a GTP-
CC       hydrolysis-dependent molecular chaperone, activating the urease
CC       apoprotein by helping to assemble the nickel containing metallocenter
CC       of UreC. The UreE protein probably delivers the nickel.
CC       {ECO:0000255|HAMAP-Rule:MF_01384}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_01384}.
CC   -!- SIMILARITY: Belongs to the UreD family. {ECO:0000255|HAMAP-
CC       Rule:MF_01384}.
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DR   EMBL; U89957; AAC00065.1; -; Genomic_DNA.
DR   RefSeq; WP_005598991.1; NZ_LS483358.1.
DR   AlphaFoldDB; O54425; -.
DR   SMR; O54425; -.
DR   STRING; 228399.appser1_17320; -.
DR   GeneID; 66258365; -.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0016151; F:nickel cation binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0006807; P:nitrogen compound metabolic process; IEA:InterPro.
DR   HAMAP; MF_01384; UreD; 1.
DR   InterPro; IPR002669; UreD.
DR   PANTHER; PTHR33643; PTHR33643; 1.
DR   Pfam; PF01774; UreD; 1.
PE   3: Inferred from homology;
KW   Chaperone; Cytoplasm; Nickel insertion.
FT   CHAIN           1..270
FT                   /note="Urease accessory protein UreD"
FT                   /id="PRO_0000067602"
SQ   SEQUENCE   270 AA;  30215 MW;  DE8C7F51D256B4B6 CRC64;
     MQSKLLLSTK LTSQGKTQLD QYFVSPPFKV MTLPAYDDAW QNGLNAMQMS SSPGLLASDL
     LDIEISLADD TALSLNTQAF TRVQSMNEGD YATQKTCIKL GKNSRLFYLP HPLVLHKDSS
     FKQTTEIEMS EQSELIYGEI VAIGRVLNGE RFAFRHFASY LRISYQNRPI IADRIQWLPA
     KMALTSLSQM EDFSHQGSLT YVNLAKNAVE IKAMVSELQA LAAEQKNMLI GVSQLNEGGL
     MVRVLAHRAD IIQHLFERIG QVLKAQSNIV