ID   URED_ALKHC              Reviewed;         271 AA.
AC   Q9KG55;
DT   02-SEP-2008, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-2000, sequence version 1.
DT   25-MAY-2022, entry version 85.
DE   RecName: Full=Urease accessory protein UreD {ECO:0000255|HAMAP-Rule:MF_01384};
GN   Name=ureD {ECO:0000255|HAMAP-Rule:MF_01384}; OrderedLocusNames=BH0258;
OS   Alkalihalobacillus halodurans (strain ATCC BAA-125 / DSM 18197 / FERM 7344
OS   / JCM 9153 / C-125) (Bacillus halodurans).
OC   Bacteria; Firmicutes; Bacilli; Bacillales; Bacillaceae; Alkalihalobacillus.
OX   NCBI_TaxID=272558;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC BAA-125 / DSM 18197 / FERM 7344 / JCM 9153 / C-125;
RX   PubMed=11058132; DOI=10.1093/nar/28.21.4317;
RA   Takami H., Nakasone K., Takaki Y., Maeno G., Sasaki R., Masui N., Fuji F.,
RA   Hirama C., Nakamura Y., Ogasawara N., Kuhara S., Horikoshi K.;
RT   "Complete genome sequence of the alkaliphilic bacterium Bacillus halodurans
RT   and genomic sequence comparison with Bacillus subtilis.";
RL   Nucleic Acids Res. 28:4317-4331(2000).
CC   -!- FUNCTION: Required for maturation of urease via the functional
CC       incorporation of the urease nickel metallocenter. {ECO:0000255|HAMAP-
CC       Rule:MF_01384}.
CC   -!- SUBUNIT: UreD, UreF and UreG form a complex that acts as a GTP-
CC       hydrolysis-dependent molecular chaperone, activating the urease
CC       apoprotein by helping to assemble the nickel containing metallocenter
CC       of UreC. The UreE protein probably delivers the nickel.
CC       {ECO:0000255|HAMAP-Rule:MF_01384}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_01384}.
CC   -!- SIMILARITY: Belongs to the UreD family. {ECO:0000255|HAMAP-
CC       Rule:MF_01384}.
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DR   EMBL; BA000004; BAB03977.1; -; Genomic_DNA.
DR   PIR; B83682; B83682.
DR   RefSeq; WP_010896440.1; NC_002570.2.
DR   AlphaFoldDB; Q9KG55; -.
DR   SMR; Q9KG55; -.
DR   STRING; 272558.10172870; -.
DR   DNASU; 892534; -.
DR   EnsemblBacteria; BAB03977; BAB03977; BAB03977.
DR   KEGG; bha:BH0258; -.
DR   eggNOG; COG0829; Bacteria.
DR   HOGENOM; CLU_056339_5_1_9; -.
DR   OMA; CQHIIVH; -.
DR   OrthoDB; 1764668at2; -.
DR   Proteomes; UP000001258; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0016151; F:nickel cation binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0006807; P:nitrogen compound metabolic process; IEA:InterPro.
DR   HAMAP; MF_01384; UreD; 1.
DR   InterPro; IPR002669; UreD.
DR   PANTHER; PTHR33643; PTHR33643; 1.
DR   Pfam; PF01774; UreD; 1.
PE   3: Inferred from homology;
KW   Chaperone; Cytoplasm; Nickel insertion; Reference proteome.
FT   CHAIN           1..271
FT                   /note="Urease accessory protein UreD"
FT                   /id="PRO_0000346552"
SQ   SEQUENCE   271 AA;  30855 MW;  73AA37CE4EBC8361 CRC64;
     MRASSHLPQL HGRLDLTFER RRGTTRLVAS EQTPPLNVSR VLRTEEVDLA TVYLVETSGG
     VVSGDSQTIA IYVGEGARVE LIPQSATKVY PSRKQGESST QQVWLRVDEG AAAFWKPESI
     IPFRKASFLQ STRFHLHSSS TFFYGDMLTP GRVHHNERFQ YEQVDSLVEI YLDETLVVHD
     RVHLQPKDQL QTIGRLDGYS YYGAVWMHAP ILKGAHLEQW MENGGQNDRF AYTCVAEGLI
     HVRWLSESSW RLRAALNDLY TAFRTFALKG E