ID   URED_ANADF              Reviewed;         297 AA.
AC   A7HHM9;
DT   10-JUN-2008, integrated into UniProtKB/Swiss-Prot.
DT   11-SEP-2007, sequence version 1.
DT   03-AUG-2022, entry version 65.
DE   RecName: Full=Urease accessory protein UreD {ECO:0000255|HAMAP-Rule:MF_01384};
GN   Name=ureD {ECO:0000255|HAMAP-Rule:MF_01384};
GN   OrderedLocusNames=Anae109_4047;
OS   Anaeromyxobacter sp. (strain Fw109-5).
OC   Bacteria; Proteobacteria; Deltaproteobacteria; Myxococcales;
OC   Cystobacterineae; Anaeromyxobacteraceae; Anaeromyxobacter;
OC   unclassified Anaeromyxobacter.
OX   NCBI_TaxID=404589;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Fw109-5;
RX   PubMed=25614562; DOI=10.1128/genomea.01449-14;
RA   Hwang C., Copeland A., Lucas S., Lapidus A., Barry K., Glavina Del Rio T.,
RA   Dalin E., Tice H., Pitluck S., Sims D., Brettin T., Bruce D.C.,
RA   Detter J.C., Han C.S., Schmutz J., Larimer F.W., Land M.L., Hauser L.J.,
RA   Kyrpides N., Lykidis A., Richardson P., Belieav A., Sanford R.A.,
RA   Loeffler F.E., Fields M.W.;
RT   "Complete genome sequence of Anaeromyxobacter sp. Fw109-5, an anaerobic,
RT   metal-reducing bacterium isolated from a contaminated subsurface
RT   environment.";
RL   Genome Announc. 3:0-0(2015).
CC   -!- FUNCTION: Required for maturation of urease via the functional
CC       incorporation of the urease nickel metallocenter. {ECO:0000255|HAMAP-
CC       Rule:MF_01384}.
CC   -!- SUBUNIT: UreD, UreF and UreG form a complex that acts as a GTP-
CC       hydrolysis-dependent molecular chaperone, activating the urease
CC       apoprotein by helping to assemble the nickel containing metallocenter
CC       of UreC. The UreE protein probably delivers the nickel.
CC       {ECO:0000255|HAMAP-Rule:MF_01384}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_01384}.
CC   -!- SIMILARITY: Belongs to the UreD family. {ECO:0000255|HAMAP-
CC       Rule:MF_01384}.
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DR   EMBL; CP000769; ABS28225.1; -; Genomic_DNA.
DR   RefSeq; WP_012098863.1; NC_009675.1.
DR   AlphaFoldDB; A7HHM9; -.
DR   SMR; A7HHM9; -.
DR   STRING; 404589.Anae109_4047; -.
DR   EnsemblBacteria; ABS28225; ABS28225; Anae109_4047.
DR   KEGG; afw:Anae109_4047; -.
DR   eggNOG; COG0829; Bacteria.
DR   HOGENOM; CLU_021703_1_1_7; -.
DR   OMA; CFRSASY; -.
DR   OrthoDB; 1764668at2; -.
DR   Proteomes; UP000006382; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0016151; F:nickel cation binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0006807; P:nitrogen compound metabolic process; IEA:InterPro.
DR   HAMAP; MF_01384; UreD; 1.
DR   InterPro; IPR002669; UreD.
DR   PANTHER; PTHR33643; PTHR33643; 1.
DR   Pfam; PF01774; UreD; 1.
PE   3: Inferred from homology;
KW   Chaperone; Cytoplasm; Nickel insertion; Reference proteome.
FT   CHAIN           1..297
FT                   /note="Urease accessory protein UreD"
FT                   /id="PRO_0000340408"
SQ   SEQUENCE   297 AA;  30716 MW;  2B7DFB9DD05AAC35 CRC64;
     MECPDPQPIL ELLEAPCPTI GQPRPEVGLR AGAGRVDIAR VDGASAIVAC VASSPLQLLA
     PSPRGRCAWI ISASHGGGLL AGDEVSLEVD VGAGAVALLS TQAGTKIYRS RGEVASQGLS
     ARVGAGALLA ALPHPVSCFS GARFRQEQRF ELARGASLLW LDALVAGRIA RGERWAFDEY
     RSRIEVAIDG RTVLADALRL VPGEGPPIVA RLPGVELLAT VVALGPAVAS AARELLERVA
     ASPAERDAGV LAAASPLRDG LLLRVASRSV EAGLAFLRQR LAFVEAVTGA DPFARTP