ID   URED_ARATH              Reviewed;         294 AA.
AC   Q7Y0S0;
DT   13-NOV-2013, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-2003, sequence version 1.
DT   03-AUG-2022, entry version 103.
DE   RecName: Full=Urease accessory protein D;
DE            Short=AtURED;
GN   Name=URED; OrderedLocusNames=At2g35035; ORFNames=F19I3;
OS   Arabidopsis thaliana (Mouse-ear cress).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC   rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX   NCBI_TaxID=3702;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, AND DISRUPTION PHENOTYPE.
RC   STRAIN=cv. Columbia;
RX   PubMed=16244137; DOI=10.1104/pp.105.070292;
RA   Witte C.P., Rosso M.G., Romeis T.;
RT   "Identification of three urease accessory proteins that are required for
RT   urease activation in Arabidopsis.";
RL   Plant Physiol. 139:1155-1162(2005).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=cv. Columbia;
RX   PubMed=10617197; DOI=10.1038/45471;
RA   Lin X., Kaul S., Rounsley S.D., Shea T.P., Benito M.-I., Town C.D.,
RA   Fujii C.Y., Mason T.M., Bowman C.L., Barnstead M.E., Feldblyum T.V.,
RA   Buell C.R., Ketchum K.A., Lee J.J., Ronning C.M., Koo H.L., Moffat K.S.,
RA   Cronin L.A., Shen M., Pai G., Van Aken S., Umayam L., Tallon L.J.,
RA   Gill J.E., Adams M.D., Carrera A.J., Creasy T.H., Goodman H.M.,
RA   Somerville C.R., Copenhaver G.P., Preuss D., Nierman W.C., White O.,
RA   Eisen J.A., Salzberg S.L., Fraser C.M., Venter J.C.;
RT   "Sequence and analysis of chromosome 2 of the plant Arabidopsis thaliana.";
RL   Nature 402:761-768(1999).
RN   [3]
RP   GENOME REANNOTATION.
RC   STRAIN=cv. Columbia;
RX   PubMed=27862469; DOI=10.1111/tpj.13415;
RA   Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA   Town C.D.;
RT   "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT   genome.";
RL   Plant J. 89:789-804(2017).
CC   -!- FUNCTION: Required for the maturation and activation of urease via the
CC       functional incorporation of the urease nickel metallocenter.
CC       {ECO:0000269|PubMed:16244137}.
CC   -!- SUBUNIT: URED, UREF and UREG may form a complex that acts as a GTP-
CC       hydrolysis-dependent molecular chaperone, activating the urease
CC       apoprotein. {ECO:0000250}.
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Alternative splicing; Named isoforms=1;
CC         Comment=A number of isoforms are produced. According to EST
CC         sequences.;
CC       Name=1;
CC         IsoId=Q7Y0S0-1; Sequence=Displayed;
CC   -!- DISRUPTION PHENOTYPE: No visible phenotype under normal growth
CC       conditions, but mutant plants cannot grow on medium with urea as the
CC       sole source of nitrogen. {ECO:0000269|PubMed:16244137}.
CC   -!- SIMILARITY: Belongs to the UreD family. {ECO:0000305}.
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DR   EMBL; AJ312202; CAC85462.1; -; mRNA.
DR   EMBL; AC004238; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; CP002685; AEC09052.1; -; Genomic_DNA.
DR   RefSeq; NP_850239.1; NM_179908.3. [Q7Y0S0-1]
DR   AlphaFoldDB; Q7Y0S0; -.
DR   SMR; Q7Y0S0; -.
DR   ComplexPortal; CPX-1296; Urease activation complex.
DR   STRING; 3702.AT2G35035.1; -.
DR   PaxDb; Q7Y0S0; -.
DR   PRIDE; Q7Y0S0; -.
DR   ProteomicsDB; 228719; -. [Q7Y0S0-1]
DR   EnsemblPlants; AT2G35035.1; AT2G35035.1; AT2G35035. [Q7Y0S0-1]
DR   GeneID; 818068; -.
DR   Gramene; AT2G35035.1; AT2G35035.1; AT2G35035. [Q7Y0S0-1]
DR   KEGG; ath:AT2G35035; -.
DR   Araport; AT2G35035; -.
DR   TAIR; locus:504956057; AT2G35035.
DR   eggNOG; ENOG502QSQN; Eukaryota.
DR   HOGENOM; CLU_021703_0_0_1; -.
DR   InParanoid; Q7Y0S0; -.
DR   OMA; CFRSASY; -.
DR   PhylomeDB; Q7Y0S0; -.
DR   PRO; PR:Q7Y0S0; -.
DR   Proteomes; UP000006548; Chromosome 2.
DR   ExpressionAtlas; Q7Y0S0; baseline and differential.
DR   GO; GO:0150006; C:urease activator complex; IPI:ComplexPortal.
DR   GO; GO:0016151; F:nickel cation binding; IEA:InterPro.
DR   GO; GO:0006807; P:nitrogen compound metabolic process; IMP:TAIR.
DR   GO; GO:1905182; P:positive regulation of urease activity; IMP:TAIR.
DR   GO; GO:0043419; P:urea catabolic process; IDA:ComplexPortal.
DR   HAMAP; MF_01384; UreD; 1.
DR   InterPro; IPR002669; UreD.
DR   PANTHER; PTHR33643; PTHR33643; 1.
DR   Pfam; PF01774; UreD; 1.
PE   2: Evidence at transcript level;
KW   Alternative splicing; Chaperone; Nickel insertion; Reference proteome.
FT   CHAIN           1..294
FT                   /note="Urease accessory protein D"
FT                   /id="PRO_0000424249"
SQ   SEQUENCE   294 AA;  32613 MW;  365E5E070AFACF2B CRC64;
     MATGKVVVEK VGGRSTATSC FSKYPLKFLL PSKAAPAGTD VVWIYSITYG GGIVSGDSIS
     CEFTIGDGCT AVITTQSSTK VYKAIGSKCS EQILEARIGS EALLVVIPDP VTCFSTARYY
     QKQIFRLLSD SNLVLVDWIT SGRHANGEKW DFEFYKSINN VYLEDDHPLF LDTVLLEKRS
     IQSIAERMQD YQAIAMVILF GAKLKEIQKQ VQENVKNMMS EQLQLSYSSR RHKSESSSRN
     RFMKPEFIAS CSTFGPEGKG VVVRIASDST ESVYNFLRQQ LAELEPVLGQ APYA