ID   URED_BORBR              Reviewed;         284 AA.
AC   P0A4R5; O06704;
DT   15-MAR-2005, integrated into UniProtKB/Swiss-Prot.
DT   15-MAR-2005, sequence version 1.
DT   25-MAY-2022, entry version 71.
DE   RecName: Full=Urease accessory protein UreD {ECO:0000255|HAMAP-Rule:MF_01384};
GN   Name=ureD {ECO:0000255|HAMAP-Rule:MF_01384}; OrderedLocusNames=BB4327;
OS   Bordetella bronchiseptica (strain ATCC BAA-588 / NCTC 13252 / RB50)
OS   (Alcaligenes bronchisepticus).
OC   Bacteria; Proteobacteria; Betaproteobacteria; Burkholderiales;
OC   Alcaligenaceae; Bordetella.
OX   NCBI_TaxID=257310;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=BB7866;
RX   PubMed=9524276; DOI=10.1016/s0378-1119(97)00651-3;
RA   McMillan D.J., Mau M., Walker M.J.;
RT   "Characterisation of the urease gene cluster in Bordetella
RT   bronchiseptica.";
RL   Gene 208:243-251(1998).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC BAA-588 / NCTC 13252 / RB50;
RX   PubMed=12910271; DOI=10.1038/ng1227;
RA   Parkhill J., Sebaihia M., Preston A., Murphy L.D., Thomson N.R.,
RA   Harris D.E., Holden M.T.G., Churcher C.M., Bentley S.D., Mungall K.L.,
RA   Cerdeno-Tarraga A.-M., Temple L., James K.D., Harris B., Quail M.A.,
RA   Achtman M., Atkin R., Baker S., Basham D., Bason N., Cherevach I.,
RA   Chillingworth T., Collins M., Cronin A., Davis P., Doggett J., Feltwell T.,
RA   Goble A., Hamlin N., Hauser H., Holroyd S., Jagels K., Leather S.,
RA   Moule S., Norberczak H., O'Neil S., Ormond D., Price C., Rabbinowitsch E.,
RA   Rutter S., Sanders M., Saunders D., Seeger K., Sharp S., Simmonds M.,
RA   Skelton J., Squares R., Squares S., Stevens K., Unwin L., Whitehead S.,
RA   Barrell B.G., Maskell D.J.;
RT   "Comparative analysis of the genome sequences of Bordetella pertussis,
RT   Bordetella parapertussis and Bordetella bronchiseptica.";
RL   Nat. Genet. 35:32-40(2003).
CC   -!- FUNCTION: Required for maturation of urease via the functional
CC       incorporation of the urease nickel metallocenter. {ECO:0000255|HAMAP-
CC       Rule:MF_01384}.
CC   -!- SUBUNIT: UreD, UreF and UreG form a complex that acts as a GTP-
CC       hydrolysis-dependent molecular chaperone, activating the urease
CC       apoprotein by helping to assemble the nickel containing metallocenter
CC       of UreC. The UreE protein probably delivers the nickel.
CC       {ECO:0000255|HAMAP-Rule:MF_01384}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_01384}.
CC   -!- SIMILARITY: Belongs to the UreD family. {ECO:0000255|HAMAP-
CC       Rule:MF_01384}.
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DR   EMBL; AF000579; AAC46124.1; -; Genomic_DNA.
DR   EMBL; BX640450; CAE34690.1; -; Genomic_DNA.
DR   RefSeq; WP_003814832.1; NC_002927.3.
DR   AlphaFoldDB; P0A4R5; -.
DR   SMR; P0A4R5; -.
DR   STRING; 257310.BB4327; -.
DR   EnsemblBacteria; CAE34690; CAE34690; BB4327.
DR   GeneID; 56477174; -.
DR   GeneID; 66440307; -.
DR   KEGG; bbr:BB4327; -.
DR   eggNOG; COG0829; Bacteria.
DR   HOGENOM; CLU_056339_0_0_4; -.
DR   OMA; CQHIIVH; -.
DR   OrthoDB; 1764668at2; -.
DR   Proteomes; UP000001027; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0016151; F:nickel cation binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0006807; P:nitrogen compound metabolic process; IEA:InterPro.
DR   HAMAP; MF_01384; UreD; 1.
DR   InterPro; IPR002669; UreD.
DR   PANTHER; PTHR33643; PTHR33643; 1.
DR   Pfam; PF01774; UreD; 1.
PE   3: Inferred from homology;
KW   Chaperone; Cytoplasm; Nickel insertion.
FT   CHAIN           1..284
FT                   /note="Urease accessory protein UreD"
FT                   /id="PRO_0000067607"
SQ   SEQUENCE   284 AA;  30967 MW;  1C57368DA55FFD3B CRC64;
     MSETLDQWRA GLTLGFAPGH AGRTVLRERA HYGPMLVQRA LYPEGPQVCH VAILHPPSGI
     AGGDALEIRV DVAGGARAAL TTPGATRWYK SNGRQASQDV HLRVAAGGRL DWLPLESIFF
     EEADALARNR IQLESGAAAI GWDLIQLGRV NQSGHWSQGR LHTATELYVD GRLLWVDQGL
     VGAQDDVRRQ VSGLAGFPVH AALWSFGPRL DAEQNEELAG LMPWSDTLRG AATTMPYDAT
     QSLCLVRCLG VHMEDVRAVM TDAWAYLRPR VLDTPAVVPR LWAT