ID   URED_BRUSI              Reviewed;         279 AA.
AC   B0CJP3;
DT   10-JUN-2008, integrated into UniProtKB/Swiss-Prot.
DT   10-JUN-2008, sequence version 2.
DT   25-MAY-2022, entry version 48.
DE   RecName: Full=Urease accessory protein UreD {ECO:0000255|HAMAP-Rule:MF_01384};
GN   Name=ureD {ECO:0000255|HAMAP-Rule:MF_01384}; OrderedLocusNames=BSUIS_A0289;
OS   Brucella suis (strain ATCC 23445 / NCTC 10510).
OC   Bacteria; Proteobacteria; Alphaproteobacteria; Hyphomicrobiales;
OC   Brucellaceae; Brucella/Ochrobactrum group; Brucella.
OX   NCBI_TaxID=470137;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 23445 / NCTC 10510;
RA   Setubal J.C., Bowns C., Boyle S., Crasta O.R., Czar M.J., Dharmanolla C.,
RA   Gillespie J.J., Kenyon R.W., Lu J., Mane S., Mohapatra S., Nagrani S.,
RA   Purkayastha A., Rajasimha H.K., Shallom J.M., Shallom S., Shukla M.,
RA   Snyder E.E., Sobral B.W., Wattam A.R., Will R., Williams K., Yoo H.,
RA   Bruce D., Detter C., Munk C., Brettin T.S.;
RT   "Brucella suis ATCC 23445 whole genome shotgun sequencing project.";
RL   Submitted (DEC-2007) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Required for maturation of urease via the functional
CC       incorporation of the urease nickel metallocenter. {ECO:0000255|HAMAP-
CC       Rule:MF_01384}.
CC   -!- SUBUNIT: UreD, UreF and UreG form a complex that acts as a GTP-
CC       hydrolysis-dependent molecular chaperone, activating the urease
CC       apoprotein by helping to assemble the nickel containing metallocenter
CC       of UreC. The UreE protein probably delivers the nickel.
CC       {ECO:0000255|HAMAP-Rule:MF_01384}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_01384}.
CC   -!- MISCELLANEOUS: The second copy of ureD in this organism is annotated as
CC       a pseudogene.
CC   -!- SIMILARITY: Belongs to the UreD family. {ECO:0000255|HAMAP-
CC       Rule:MF_01384}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=ABY37384.1; Type=Frameshift; Evidence={ECO:0000305};
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DR   EMBL; CP000911; ABY37384.1; ALT_FRAME; Genomic_DNA.
DR   AlphaFoldDB; B0CJP3; -.
DR   SMR; B0CJP3; -.
DR   EnsemblBacteria; ABY37384; ABY37384; BSUIS_A0289.
DR   KEGG; bmt:BSUIS_A0289; -.
DR   HOGENOM; CLU_056339_2_0_5; -.
DR   Proteomes; UP000008545; Chromosome I.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0016151; F:nickel cation binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0006807; P:nitrogen compound metabolic process; IEA:InterPro.
DR   HAMAP; MF_01384; UreD; 1.
DR   InterPro; IPR002669; UreD.
DR   PANTHER; PTHR33643; PTHR33643; 1.
DR   Pfam; PF01774; UreD; 1.
PE   3: Inferred from homology;
KW   Chaperone; Cytoplasm; Nickel insertion.
FT   CHAIN           1..279
FT                   /note="Urease accessory protein UreD"
FT                   /id="PRO_0000340429"
SQ   SEQUENCE   279 AA;  30127 MW;  71DD1C2A4308B691 CRC64;
     MLIINDNNLS GPLQRVNGTG ELSVQFKDGR SRISRLYQEG AAKIRMPQAV TGPLEAILIN
     TSGGLTGGDR LKWDVALDDG ASAVITTQAC ERIYRSGGGE ARIATRLKAA KGTRLAWLPQ
     ETILFNRSIL SRRLDVELEE GAQMLVVEAT VFGRLAMGER VVAARFADRW RVRLGGRVIH
     AEEFRLGPDV GAELQAPAVA GGACAMATVL MVCEQAGRHL ETARAIIGEE GGCSLWRVGK
     ASKLVVRLYA PDSYALRRRL CPLVALLNGK AGLPKVWTI