ID   URED_BURL3              Reviewed;         291 AA.
AC   Q39IW0;
DT   10-JUN-2008, integrated into UniProtKB/Swiss-Prot.
DT   22-NOV-2005, sequence version 1.
DT   25-MAY-2022, entry version 69.
DE   RecName: Full=Urease accessory protein UreD {ECO:0000255|HAMAP-Rule:MF_01384};
GN   Name=ureD {ECO:0000255|HAMAP-Rule:MF_01384};
GN   OrderedLocusNames=Bcep18194_A4009;
OS   Burkholderia lata (strain ATCC 17760 / DSM 23089 / LMG 22485 / NCIMB 9086 /
OS   R18194 / 383).
OC   Bacteria; Proteobacteria; Betaproteobacteria; Burkholderiales;
OC   Burkholderiaceae; Burkholderia; Burkholderia cepacia complex.
OX   NCBI_TaxID=482957;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 17760 / DSM 23089 / LMG 22485 / NCIMB 9086 / R18194 / 383;
RG   US DOE Joint Genome Institute;
RA   Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina T.,
RA   Hammon N., Israni S., Pitluck S., Chain P., Malfatti S., Shin M.,
RA   Vergez L., Schmutz J., Larimer F., Land M., Kyrpides N., Lykidis A.,
RA   Richardson P.;
RT   "Complete sequence of chromosome 1 of Burkholderia sp. 383.";
RL   Submitted (OCT-2005) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Required for maturation of urease via the functional
CC       incorporation of the urease nickel metallocenter. {ECO:0000255|HAMAP-
CC       Rule:MF_01384}.
CC   -!- SUBUNIT: UreD, UreF and UreG form a complex that acts as a GTP-
CC       hydrolysis-dependent molecular chaperone, activating the urease
CC       apoprotein by helping to assemble the nickel containing metallocenter
CC       of UreC. The UreE protein probably delivers the nickel.
CC       {ECO:0000255|HAMAP-Rule:MF_01384}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_01384}.
CC   -!- SIMILARITY: Belongs to the UreD family. {ECO:0000255|HAMAP-
CC       Rule:MF_01384}.
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DR   EMBL; CP000151; ABB07606.1; -; Genomic_DNA.
DR   RefSeq; WP_011351187.1; NC_007510.1.
DR   AlphaFoldDB; Q39IW0; -.
DR   SMR; Q39IW0; -.
DR   EnsemblBacteria; ABB07606; ABB07606; Bcep18194_A4009.
DR   GeneID; 45093908; -.
DR   KEGG; bur:Bcep18194_A4009; -.
DR   PATRIC; fig|482957.22.peg.889; -.
DR   HOGENOM; CLU_056339_0_0_4; -.
DR   OMA; CQHIIVH; -.
DR   OrthoDB; 1764668at2; -.
DR   Proteomes; UP000002705; Chromosome 1.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0016151; F:nickel cation binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0006807; P:nitrogen compound metabolic process; IEA:InterPro.
DR   HAMAP; MF_01384; UreD; 1.
DR   InterPro; IPR002669; UreD.
DR   PANTHER; PTHR33643; PTHR33643; 1.
DR   Pfam; PF01774; UreD; 1.
PE   3: Inferred from homology;
KW   Chaperone; Cytoplasm; Nickel insertion.
FT   CHAIN           1..291
FT                   /note="Urease accessory protein UreD"
FT                   /id="PRO_0000340441"
SQ   SEQUENCE   291 AA;  30981 MW;  66413A954DFA20BD CRC64;
     MSAPDSRAPL SRPAVAKSWH GRLELGFERH GMRTTLAHRL HDGPLRVQRP LYPEGDAICH
     AVIVHPPGGV AGGDRLDIDI ALGDGTHAVL TTPGATKWYK SNGLDATQRI GITVGEHAKL
     DWLPQNNLFF DAAHASLDFT VKLGTGATAI GWDASQLGRQ AAGETWSAGR VASTSALVDA
     DGRPLWTERA LLDAHDPLRG ALQGLAGFPA YGTLWAAGAA CDAALAESLA ARMPFDATLR
     AGATCVTPGV VLVRALSTSM EALQRHFTDC WLHLRPIVHG VDARPLRLWQ T