ID   URED_BURP1              Reviewed;         291 AA.
AC   Q3JPJ9;
DT   10-JUN-2008, integrated into UniProtKB/Swiss-Prot.
DT   10-JUN-2008, sequence version 2.
DT   03-AUG-2022, entry version 63.
DE   RecName: Full=Urease accessory protein UreD {ECO:0000255|HAMAP-Rule:MF_01384};
GN   Name=ureD {ECO:0000255|HAMAP-Rule:MF_01384};
GN   OrderedLocusNames=BURPS1710b_3132;
OS   Burkholderia pseudomallei (strain 1710b).
OC   Bacteria; Proteobacteria; Betaproteobacteria; Burkholderiales;
OC   Burkholderiaceae; Burkholderia; pseudomallei group.
OX   NCBI_TaxID=320372;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=1710b;
RX   PubMed=20333227; DOI=10.1093/gbe/evq003;
RA   Losada L., Ronning C.M., DeShazer D., Woods D., Fedorova N., Kim H.S.,
RA   Shabalina S.A., Pearson T.R., Brinkac L., Tan P., Nandi T., Crabtree J.,
RA   Badger J., Beckstrom-Sternberg S., Saqib M., Schutzer S.E., Keim P.,
RA   Nierman W.C.;
RT   "Continuing evolution of Burkholderia mallei through genome reduction and
RT   large-scale rearrangements.";
RL   Genome Biol. Evol. 2:102-116(2010).
CC   -!- FUNCTION: Required for maturation of urease via the functional
CC       incorporation of the urease nickel metallocenter. {ECO:0000255|HAMAP-
CC       Rule:MF_01384}.
CC   -!- SUBUNIT: UreD, UreF and UreG form a complex that acts as a GTP-
CC       hydrolysis-dependent molecular chaperone, activating the urease
CC       apoprotein by helping to assemble the nickel containing metallocenter
CC       of UreC. The UreE protein probably delivers the nickel.
CC       {ECO:0000255|HAMAP-Rule:MF_01384}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_01384}.
CC   -!- SIMILARITY: Belongs to the UreD family. {ECO:0000255|HAMAP-
CC       Rule:MF_01384}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=ABA47805.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR   EMBL; CP000124; ABA47805.1; ALT_INIT; Genomic_DNA.
DR   RefSeq; WP_004185533.1; NC_007434.1.
DR   AlphaFoldDB; Q3JPJ9; -.
DR   SMR; Q3JPJ9; -.
DR   EnsemblBacteria; ABA47805; ABA47805; BURPS1710b_3132.
DR   GeneID; 56594816; -.
DR   KEGG; bpm:BURPS1710b_3132; -.
DR   HOGENOM; CLU_056339_0_0_4; -.
DR   OrthoDB; 1764668at2; -.
DR   Proteomes; UP000002700; Chromosome I.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0016151; F:nickel cation binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0006807; P:nitrogen compound metabolic process; IEA:InterPro.
DR   HAMAP; MF_01384; UreD; 1.
DR   InterPro; IPR002669; UreD.
DR   PANTHER; PTHR33643; PTHR33643; 1.
DR   Pfam; PF01774; UreD; 1.
PE   3: Inferred from homology;
KW   Chaperone; Cytoplasm; Nickel insertion.
FT   CHAIN           1..291
FT                   /note="Urease accessory protein UreD"
FT                   /id="PRO_0000340439"
SQ   SEQUENCE   291 AA;  30980 MW;  EA704623B8A72259 CRC64;
     MSAHEPHTSL VRPAAKAWHA RLELGFERQP GGRTALAHRR HVGPLRVQRA LYPEGDAICH
     AVIVHPPGGV AGGDRLEIDV RLDAGTHAVL TTPGATKWYK SNGLDARQRI DIDVGAHAKL
     DWLPQNNLFF DAAHASLEFV LALGDGASVL GWDATQLGRQ AAGEAWSAGS IASFSKIVGP
     SGRPLWVERA RLDAGDPLRA APQGLGGFAV YGTLWALGAA CTEALAESIA PALPFDDALR
     AGVTCVAPGT LLIRALAHSM EALQRLLAEQ WLALRPIVHG VDPKPLRLWQ T