ID   URED_BURTA              Reviewed;         291 AA.
AC   Q2SYF4;
DT   10-JUN-2008, integrated into UniProtKB/Swiss-Prot.
DT   10-JUN-2008, sequence version 2.
DT   03-AUG-2022, entry version 66.
DE   RecName: Full=Urease accessory protein UreD {ECO:0000255|HAMAP-Rule:MF_01384};
GN   Name=ureD {ECO:0000255|HAMAP-Rule:MF_01384}; OrderedLocusNames=BTH_I1499;
OS   Burkholderia thailandensis (strain ATCC 700388 / DSM 13276 / CIP 106301 /
OS   E264).
OC   Bacteria; Proteobacteria; Betaproteobacteria; Burkholderiales;
OC   Burkholderiaceae; Burkholderia; pseudomallei group.
OX   NCBI_TaxID=271848;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 700388 / DSM 13276 / CIP 106301 / E264;
RX   PubMed=16336651; DOI=10.1186/1471-2164-6-174;
RA   Kim H.S., Schell M.A., Yu Y., Ulrich R.L., Sarria S.H., Nierman W.C.,
RA   DeShazer D.;
RT   "Bacterial genome adaptation to niches: divergence of the potential
RT   virulence genes in three Burkholderia species of different survival
RT   strategies.";
RL   BMC Genomics 6:174-174(2005).
CC   -!- FUNCTION: Required for maturation of urease via the functional
CC       incorporation of the urease nickel metallocenter. {ECO:0000255|HAMAP-
CC       Rule:MF_01384}.
CC   -!- SUBUNIT: UreD, UreF and UreG form a complex that acts as a GTP-
CC       hydrolysis-dependent molecular chaperone, activating the urease
CC       apoprotein by helping to assemble the nickel containing metallocenter
CC       of UreC. The UreE protein probably delivers the nickel.
CC       {ECO:0000255|HAMAP-Rule:MF_01384}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_01384}.
CC   -!- SIMILARITY: Belongs to the UreD family. {ECO:0000255|HAMAP-
CC       Rule:MF_01384}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=ABC38588.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR   EMBL; CP000086; ABC38588.1; ALT_INIT; Genomic_DNA.
DR   RefSeq; WP_009889616.1; NZ_CP008785.1.
DR   AlphaFoldDB; Q2SYF4; -.
DR   SMR; Q2SYF4; -.
DR   PRIDE; Q2SYF4; -.
DR   EnsemblBacteria; ABC38588; ABC38588; BTH_I1499.
DR   KEGG; bte:BTH_I1499; -.
DR   HOGENOM; CLU_056339_0_0_4; -.
DR   OrthoDB; 1764668at2; -.
DR   Proteomes; UP000001930; Chromosome I.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0016151; F:nickel cation binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0006807; P:nitrogen compound metabolic process; IEA:InterPro.
DR   HAMAP; MF_01384; UreD; 1.
DR   InterPro; IPR002669; UreD.
DR   PANTHER; PTHR33643; PTHR33643; 1.
DR   Pfam; PF01774; UreD; 1.
PE   3: Inferred from homology;
KW   Chaperone; Cytoplasm; Nickel insertion.
FT   CHAIN           1..291
FT                   /note="Urease accessory protein UreD"
FT                   /id="PRO_0000340442"
SQ   SEQUENCE   291 AA;  31118 MW;  CAFAC7F4E5C379AE CRC64;
     MSAHDPHASL ARPAAKAWHA RLELGFERQP GGRTALAHRR HVGPLRVQRA LYPEGDAICH
     AVIVHPPGGV AGGDRLEIDV KLDAGTHAVL TTPGATKWYK SNGLDARQRI DIDVGARAKL
     DWLPQNNLFF DATHASLEFV LKLGDGASVL GWDAAQLGRQ AAGEAWSTGS VASFSKIVGP
     SGRALWVERA RLDARDPLRA APQGLGGFPV YGTLWALGPA CTNALAESIA PALPFDDALR
     AGVTCIAPGT MLIRALAHSM EALQHLFAEQ WLALRPIVHG IDAKPLRLWQ T