URED_CERS4
ID URED_CERS4 Reviewed; 275 AA.
AC Q3J149; Q9RFF6;
DT 10-JUN-2008, integrated into UniProtKB/Swiss-Prot.
DT 08-NOV-2005, sequence version 1.
DT 25-MAY-2022, entry version 69.
DE RecName: Full=Urease accessory protein UreD {ECO:0000255|HAMAP-Rule:MF_01384};
GN Name=ureD {ECO:0000255|HAMAP-Rule:MF_01384}; OrderedLocusNames=RHOS4_19170;
GN ORFNames=RSP_0310;
OS Cereibacter sphaeroides (strain ATCC 17023 / DSM 158 / JCM 6121 / CCUG
OS 31486 / LMG 2827 / NBRC 12203 / NCIMB 8253 / ATH 2.4.1.) (Rhodobacter
OS sphaeroides).
OC Bacteria; Proteobacteria; Alphaproteobacteria; Rhodobacterales;
OC Rhodobacteraceae; Cereibacter.
OX NCBI_TaxID=272943;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=10648776; DOI=10.1093/nar/28.4.862;
RA Choudhary M., Kaplan S.;
RT "DNA sequence analysis of the photosynthesis region of Rhodobacter
RT sphaeroides 2.4.1.";
RL Nucleic Acids Res. 28:862-867(2000).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 17023 / DSM 158 / JCM 6121 / CCUG 31486 / LMG 2827 / NBRC 12203
RC / NCIMB 8253 / ATH 2.4.1.;
RA Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina T.,
RA Hammon N., Israni S., Pitluck S., Richardson P., Mackenzie C.,
RA Choudhary M., Larimer F., Hauser L.J., Land M., Donohue T.J., Kaplan S.;
RT "Complete sequence of chromosome 1 of Rhodobacter sphaeroides 2.4.1.";
RL Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Required for maturation of urease via the functional
CC incorporation of the urease nickel metallocenter. {ECO:0000255|HAMAP-
CC Rule:MF_01384}.
CC -!- SUBUNIT: UreD, UreF and UreG form a complex that acts as a GTP-
CC hydrolysis-dependent molecular chaperone, activating the urease
CC apoprotein by helping to assemble the nickel containing metallocenter
CC of UreC. The UreE protein probably delivers the nickel.
CC {ECO:0000255|HAMAP-Rule:MF_01384}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_01384}.
CC -!- SIMILARITY: Belongs to the UreD family. {ECO:0000255|HAMAP-
CC Rule:MF_01384}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAF24251.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR EMBL; AF195122; AAF24251.1; ALT_INIT; Genomic_DNA.
DR EMBL; CP000143; ABA79485.1; -; Genomic_DNA.
DR RefSeq; WP_011338140.1; NZ_CP030271.1.
DR RefSeq; YP_353386.1; NC_007493.2.
DR AlphaFoldDB; Q3J149; -.
DR SMR; Q3J149; -.
DR STRING; 272943.RSP_0310; -.
DR EnsemblBacteria; ABA79485; ABA79485; RSP_0310.
DR KEGG; rsp:RSP_0310; -.
DR PATRIC; fig|272943.9.peg.2257; -.
DR eggNOG; COG0829; Bacteria.
DR OMA; MARFCAQ; -.
DR PhylomeDB; Q3J149; -.
DR Proteomes; UP000002703; Chromosome 1.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0016151; F:nickel cation binding; IEA:UniProtKB-UniRule.
DR GO; GO:0006807; P:nitrogen compound metabolic process; IEA:InterPro.
DR HAMAP; MF_01384; UreD; 1.
DR InterPro; IPR002669; UreD.
DR PANTHER; PTHR33643; PTHR33643; 1.
DR Pfam; PF01774; UreD; 1.
PE 3: Inferred from homology;
KW Chaperone; Cytoplasm; Nickel insertion; Reference proteome.
FT CHAIN 1..275
FT /note="Urease accessory protein UreD"
FT /id="PRO_0000340505"
FT CONFLICT 51
FT /note="V -> VLVM (in Ref. 1; AAF24251)"
FT /evidence="ECO:0000305"
FT CONFLICT 126
FT /note="A -> P (in Ref. 1; AAF24251)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 275 AA; 28742 MW; BB0FF197520FB0C8 CRC64;
MNALTPLSAR LERSDGHALV TLARSRGAVR LRDLAQRGSA KAFLPRVEGD VPEVVFLNTS
GGLTGGDRLS YRLEVGEGCR ATATTQTAER AYAAGAGAAR VEVLHEVGRD GWLDWLPQET
ILFEGAALER ETQISLAPGA GCLMVESVVL GRAAMGETLS RLAFRDRRSI LRGGKPVVVE
PLALDDRALA AAGGAAMLGG ARALATLAMV GPGAEDALGP ARAALGEAGV EAAASAFDGK
LVLRLLAADG WPLRRQVARL LTVLRGRALP RVWQV
