ID   URED_CITK8              Reviewed;         285 AA.
AC   A8APU7;
DT   02-SEP-2008, integrated into UniProtKB/Swiss-Prot.
DT   23-OCT-2007, sequence version 1.
DT   25-MAY-2022, entry version 61.
DE   RecName: Full=Urease accessory protein UreD {ECO:0000255|HAMAP-Rule:MF_01384};
GN   Name=ureD {ECO:0000255|HAMAP-Rule:MF_01384}; OrderedLocusNames=CKO_04454;
OS   Citrobacter koseri (strain ATCC BAA-895 / CDC 4225-83 / SGSC4696).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Citrobacter.
OX   NCBI_TaxID=290338;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC BAA-895 / CDC 4225-83 / SGSC4696;
RG   The Citrobacter koseri Genome Sequencing Project;
RA   McClelland M., Sanderson E.K., Porwollik S., Spieth J., Clifton W.S.,
RA   Latreille P., Courtney L., Wang C., Pepin K., Bhonagiri V., Nash W.,
RA   Johnson M., Thiruvilangam P., Wilson R.;
RL   Submitted (AUG-2007) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Required for maturation of urease via the functional
CC       incorporation of the urease nickel metallocenter. {ECO:0000255|HAMAP-
CC       Rule:MF_01384}.
CC   -!- SUBUNIT: UreD, UreF and UreG form a complex that acts as a GTP-
CC       hydrolysis-dependent molecular chaperone, activating the urease
CC       apoprotein by helping to assemble the nickel containing metallocenter
CC       of UreC. The UreE protein probably delivers the nickel.
CC       {ECO:0000255|HAMAP-Rule:MF_01384}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_01384}.
CC   -!- SIMILARITY: Belongs to the UreD family. {ECO:0000255|HAMAP-
CC       Rule:MF_01384}.
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DR   EMBL; CP000822; ABV15510.1; -; Genomic_DNA.
DR   AlphaFoldDB; A8APU7; -.
DR   SMR; A8APU7; -.
DR   STRING; 290338.CKO_04454; -.
DR   PRIDE; A8APU7; -.
DR   EnsemblBacteria; ABV15510; ABV15510; CKO_04454.
DR   KEGG; cko:CKO_04454; -.
DR   HOGENOM; CLU_056339_0_0_6; -.
DR   OMA; CQHIIVH; -.
DR   Proteomes; UP000008148; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0016151; F:nickel cation binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0006807; P:nitrogen compound metabolic process; IEA:InterPro.
DR   HAMAP; MF_01384; UreD; 1.
DR   InterPro; IPR002669; UreD.
DR   PANTHER; PTHR33643; PTHR33643; 1.
DR   Pfam; PF01774; UreD; 1.
PE   3: Inferred from homology;
KW   Chaperone; Cytoplasm; Nickel insertion; Reference proteome.
FT   CHAIN           1..285
FT                   /note="Urease accessory protein UreD"
FT                   /id="PRO_0000346558"
SQ   SEQUENCE   285 AA;  31892 MW;  222CBCDE698ABFE9 CRC64;
     MHSPHADKGN ALDTVAHKTL TRGWQAELDL RFTRAAHKTV LTSARHVGPL TVQRPFYPED
     DVCHLYLLHP PGGIVGGDEL TISATLATDS HALITQPGSG KFYRSRGPQA QLRQDFYLAP
     QATLEWLPQD TILFPGANAN IQSVFHLAQE SRLLAWDLLC LGRPVMQETF SHGTLRNRLE
     VWRDGTPLLI ERLHLEGGSL HTVARHPWSG TLLCYPATEK MLDGVREQIA PLGDYAGATL
     IDSLLALRFL GHDNLLIQRV MRAVWQSLRP QLTQKPPLLP RIWQT